Laser-induced nanobubbles for advanced therapies in the eye.

Doctoral project Arianna Oddo

Doctoral project Bart Geers

Doctoral project Freya Joris

Doctoral project Geertrui Tavernier

Doctoral project Inès De Hoon

Doctoral project Jelter Van Hoeck

Doctoral project Lore Herman

Doctoral project Lynn De Backer

Doctoral project Nathalie Symens

Doctoral project Rein Verbeke

Doctoral project Rita Sobral Fernandes Machado dos Santos

Doctoral project Roberta Guagliardo

Doctoral project Silke Roovers

Doctoral project Stephan Stremersch

Doctoral project Thijs Van de Vyver

Exploration of an mRNA based nanovaccine platform and immunopeptidomics for the development of more effective tuberculosis vaccines.

Exploration of mRNA-LNPs for in situ generation of CAR-macrophages

Exploring biochemical and biophysical methods for the delivery of biologics to the corneal epithelium.

Exploring (Bio-) polymeric matrices and light for advanced pharmaceutical and medical applications.

Exploring novel drug delivery strategies in rheumatoid arthritis: Nanomedicines and ultrasound triggered drug delivery.

High-Intensity Focused ultrasound to induce and boost anti-tumor immunity.

Light-responsive polymer for efficient intracellular delivery of biomacromolecules

Nanoparticle design for the targeted delivery of adjuvants to the lymph nodes

Novel strategies to treat vitreous opacities

The impact of mRNA galsome formulation on immunogenicity and reactogenicity

Towards new strategies to destroy protein aggregates in the vitreous

Towards the clinical evaluation of Galsome-NEO, a glycolipid-adjuvanted mRNA cancer vaccine.

A lipid nanoparticle platform for RNA delivery with cationic amphiphilic drugs: merging the best of both worlds.

Design and application of acoustic tweezers to enhance surgery and drug delivery in ophthalmology.

Development and evaluation of nanoformulations for inhalation of RNA therapeutics

Doctoral project George Dakwar

Doctoral project Heyang Zhang

Doctoral project Joke Devoldere

Doctoral project Karen Peynshaert

Doctoral project Lore Herman

Doctoral project Molood Shariati

Doctoral project Thomas Martens

Doctoral project Zifu Zhong

Drug-like features in antibodies with ultra-long CDRs

High pressure nebulization of smart hydrogels: driving intraperitoneal drug delivery forward

Ocular enzyme delivery and nanotechnology: expanding the therapeutic horizon for (vitreo)retinal disease.

Strategies to overcome the lysosomal entrapment of siRNA therapeutics and chemotherapeutic drugs.

Accellerating towards clinical validation of Galsome nanovaccines

Affording Recovery after stroke

Alliance Research Group: Particle based cancer immunotherapy

Analysis and prevention of protein particle formation – An approach towards safer antibody drugs in the clinic

A platform for the fast development of thermostable lyophilized mRNA lipid nanoparticle (LNP) vaccines

Applying spatial and temporal growth factor concentration gradients through release from electrospun polymer micorfibers

Biodegradable dextran nanogels for the intracellular controlled release of short interfering RNA (siRNA)

Bio-inspired nanocomposites of pulmonary surfactant and hydrogel nanoparticles for siRNA inhalation therapy

Centre for Advanced Light Microscopy

‘Clear-View’ - photoablation of vitreous opacities

Cofunding core facility - Ghent Light Microscopy (GLiM)

Collaboration on the optimisation of macromolecular pharmaceutical access to cellular targets (COMPACT)

Combatting multiple myeloma using Galsome immunotherapy

Cytotoxic cell-mediated delivery of nucleic acid nanoparticles as a synergistic cancer immunotherapy

cytotoxic T cells as transport vehicles for tumor-targeted delivery of nanomedicines

Design and evaluation of mRNA loaded microbubbles for ultrasound triggered cancer vaccination.

Design and evaluation of rtPA loaded microbubbles for sonothrombolysis.

Detection of atherosclerotic plaques by MRI and optical images

Development and optimization of cell culture protocols for studying cell-nanoparticle interactions

Doxorubicin-loaded microbubbles for ultrasound controlled destruction of tumor cells

Evaluating the potential of nanomaterials for IP administration of chemotherapeutics and nucleic acids / Nanomedicine: an integrative approach

Evaluation of formulation parameters o n the mRNA integrity within mRNA lipid nanoparticles

Evaluation of microbubbles loaded with chemotherapeutics for ultrasound triggered treatment of pancreatic cancer.

Evaluation of mRNA loaded microbubbles for untrasound guided cancer vaccination

Evaluation of small interfering RNA delivery using nanoparticle-laden tumoritrope cells

Evaluation of small interfering RNA delivery via nano-particle-laden cells tumoritrope

Exosome-inspired nanocarriers for the delivery of small interfering RNA

Exploration of an mRNA based nanovaccine platform and immunopeptidomics for the development of more effective tuberculosis vaccines.

Exploring and advancing mRNA lipid nanoparticles for the in situ generation of CAR-Ms

Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.

Facultair Mobiliteits- en Sabbaticalfonds faculteit Pharmaceutical sciences

Flow cytometer

Fluorescence correlation spectroscopy

Francqui Chair 2013-2014 prof. Daan Crommelin

Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.

High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity

Immunopeptidomics-based Development of Next-Generation Bacterial mRNA Vaccines

Intraperitoneal gene delivery of to prevent the formation and growth of peritoneal metastases: nanoparticle optimization and development of a thermosensitive hydrogel

In vivo transduction of dendritic cells with mRNA for the development of an immunotherapy

Laser-induced nanobubbles for advanced therapies in the eye

Liposome loaded microbubbles for the ultrasound triggered release of corticosteroids and TNF-α siRNA in the inflamed synovial tissue during rheumatoid arthritis.

LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cells

Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo.

mRNA Lipid nanoparticles co-loaded with alpha-Galactosylceramide as a universal influenza vaccine platform

NanoCoMIT: Targeted nanoparticles for combined multimodal imaging and therapy

Nanomedicine: an integrative approach

non-invasive imaging of migration and survival of stem cells in the brain

Non-viral mediated mRNA based reprogramming of fibroblasts to pluripotent stem cells: overcoming immunogenicity and the need for multiple administrations

Novel molecular intervention technology for infectious and allergic respiratory diseases

Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells

Optimization and elucidation of ultrasound-induced transfection of cardiac endothelial cells with SDF-1 for the purpose of stem cell migration

Photo-induced destruction of protein aggregates and liquefaction of the vitreous humour using light sensitive nanomaterials.

Photo-induced destruction of protein aggregates and liquefaction of vitreous humour using nanobubbles generating liposomes

Pulmonary delivery of small RNAs

Repurposing of cationic amphiphilic drugs as adjuvants to enhance the cellular delivery of small interfering RNA

RNA-MAGIC: RNA-based bioMArkers and tarGets In asthma and Chronic Obstructive Pulmonary Disease (COPD)

Screening for molecular adjuvants to enhance cytoplasmic delivery of small interfering RNA in cancer cells

Seeing is believing: Unraveling inflammation processes in auto-immune diabetes with non-invasive imaging.

Smart design nanoParticles to Activate immune Responses against Cancer (SPARC)

Sonodrugs-image-controlled ultrasound- induced drug delivery

Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)

Understanding and modulating the pro-inflammatory activity of lipid nanoparticles (LNP) in the COVID-19 mRNA vaccines: towards the development of more effective LNP formulations.

A basic whole-body bioluminescent and fluorescent in vivo imaging system for small laboratory animals

A microfluidics approach towards contact-free laser-induced photoporation for cell-based therapies

An eco-evolutionary network of biotic interactions

Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samples

ILM photodisruption: a biophotonic approach to promote retinal ganglion cell engraftment as a cure for blindness

Intraperitoneal nebulization of thermosensitive hydrogels for the controlled release of chemotherapeutics and biopharmaceuticals to treat peritoneal carcinomatosis

Laser bench for laser scanning confocal microscopy

Light-triggered nanobombs for intracellular delivery of functional macromolecules

Nanoparticle-induced autophagy: unraveling the impact on nanoparticle toxicity and therapeutic efficacy

Photoporation of the inner limiting membrane to enhance retinal drug delivery after intravitreal injection

Quantum dot nanoparticles for live cell imaging and intracellular targeting.

Repurposing lung surfactant protein B for inhalation therapy with RNA therapeutics

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

Universal antibody scaffolds with drug-like features for straightforward mini-domain grafting

Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapy