Project

Intraperitoneal gene delivery of to prevent the formation and growth of peritoneal metastases: nanoparticle optimization and development of a thermosensitive hydrogel

Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
metastases siRNA intraperitoneal fluid
 
Project description

Intraperitoneal non-viral nucleic acid delivery is attractive to target peritoneal metastases. We aim to evaluate the stability and aggregation non-viral gene complexes in the peritoneal fluid, by using Fluorescence Fluctuation Spectroscopy and Single Particle Tracking. Also, we aim to develop a thermosensitive hydrogel formulation for delivery of nucleic acids in the intraperitoneal cavity during a prolonged period of time.