Project

Evaluation of microbubbles loaded with chemotherapeutics for ultrasound triggered treatment of pancreatic cancer.

Duration
01 October 2015 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Morphological sciences
    • Oncology
Keywords
microbubbles chemotherapy ultrasound
 
Project description

Drug-loaded microbubbles are under development to selectively deliver drugs in tissues exposed to ultrasound. In this project we aim to design chemotherapeutic loaded microbubbles and evaluate whether they can increase the chemosensitivity of pancreatic tumors after ultrasound treatment. Microbubble implosions might disrupt the dense tumor stroma and that this could improve the penetration of chemotherapeutics in the tumor stroma and reduce chemoresistance.