Biodegradable dextran nanogels for the intracellular controlled release of short interfering RNA (siRNA)

01 January 2008 → 31 December 2012
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Chemical product design and formulation
    • Biomaterials engineering
biodegradable siRNA nanogel controlled release
Project description

For in vivo application of therapeutic siRNA, effective delivery is still defined as the major hurdle to overcome. Also, appropriate attention should be paid to optimize the gene silencing effect, both in terms of magnitude and duration. The major focus of this project is therefore the design of dextran nanogels for intracellular controlled release of siRNA.