Project

Evaluation of mRNA loaded microbubbles for untrasound guided cancer vaccination

Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
immunotherapy mRNA cancer vaccination microbubbles ultrasound TriMix
 
Project description

Dendritic cells, the professional antigen-presenting cells of our immune system, induce cytotoxic T lymphocyte responses against tumor-associated antigens. Consequently, there has been much interest in their application as anti-tumor vaccines. In this study we willcombine the expertise of the GRGN and LMCT to evaluate the use of mRNA-loaded microbubbles and ultrasound to modify DCs ex vivo as well as intradally to boost anti-tumor immunity. These data together with the fact that the use of mRNA-loaded microbubbles could provide a way to manipulate DCs in vio, warrant an in dept evaluation of this mRNA-loaded microbubble-based vaccination strategy.