Project

Liposome loaded microbubbles for the ultrasound triggered release of corticosteroids and TNF-α siRNA in the inflamed synovial tissue during rheumatoid arthritis.

Duration
01 October 2017 → 30 September 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Orthopaedics
    • Orthopaedics
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Orthopaedics
Keywords
rheumatoid arthritis microbubbles ultrasound liposomes corticosteroids siRNA
 
Project description

Rheumatoid arthritis is an inflammatory autoimmune disease characterized by synovial inflammation. In close collaboration with the rheumatoid arthritis group we will evaluate microbubbles and ultrasound for the controlled delivery of corticosteroid and siRNA to inflamed synovial tissue. We hypothesize the use of microbubbles and ultrasound might increase the intraarticular
concentration of corticosteroids and TNF-α siRNA and reduce their side-effects.