Design and evaluation of rtPA loaded microbubbles for sonothrombolysis.

01 October 2007 → 25 February 2017
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Medical biochemistry and metabolism
Project description

Thrombolytics are injected intraveneously to degrade blood clots causing ischemic stroke and acute myocardinfarcts. Recently also microbubbles and ultrasound have been applied to mechanically degrade tne thrombus. The aim of this project is to design rtPA loaded microbubbles. After ultrasound explosure of the thrombus, the microbubbles will locally release their thrombolytics and in this way diminish the systemic side effects of thrombolytics.