Project

Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells

Duration
01 January 2008 → 28 February 2012
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Chemical product design and formulation
    • Process engineering
    • Polymeric materials
    • Biomaterials engineering
Keywords
plasmid DNA non-viral gene therapy nuclear membrane
 
Project description

Plasmid DNA needs to reach the cell nucleus to be biologically active. We aim to explore new strategies to target naked DNA or DNA nanoparticles to the cell nuclei of daughter cells during the cell division of the mother cell, since during cell division the intracellular barrier of the nuclear membrane is temporarily broken down.