Project

The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)

Duration
01 October 2010 → 05 January 2016
Funding
Regional and community funding: IWT/VLAIO
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
Keywords
cancer vaccination ultrasound dendritic cells mRNA microbubbles
 
Project description

This project focuses on the use of mRNA-lipoplex loaded microbubbles for ultrasound-assisted cancer vaccination. The goal is to evaluate to what extent sonoporation (using microbubbles and ultrasound) can be used to transfect dendritic cells, what the effect of sonoporation on the cells and their function is, and how the resulting antitumor immune responses can be maximized in vivo.