In elderly, vitreous liquefaction is associated with the formation of opacities within the vitreous (‘eye floaters’). These opacities can cause significant impairment in vision. All too often, patients are left untreated and must cope with their symptoms. Ghent University has introduced ‘nanobubble ablation’ for destruction of vitreous opacities. It was found that following intravitreal injection of photosensitizers, designed to accumulate on vitreous opacities, applying laser pulses at a low energy generates vapor nanobubbles which mechanically destroy the opacities in (rabbit) eyes and in specimens obtained by vitrectomy in patients suffering from eye floaters. As besides efficacy, safety of the treated eyes is as important, this project will evaluate the efficacy and safety of two photosensitizers. The project further aims to define the regulatory strategy and will approach pharma and ocular laser-industry to identify an optimal business model for UGent.