Project

Design and evaluation of mRNA loaded microbubbles for ultrasound triggered cancer vaccination.

Duration
01 October 2007 → 25 February 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Immunology
Keywords
cancer vaccination microbubbles ultrasound
 
Project description

In this project we will evaluate whether mRNA loaded microbubbles can be developed for the ultrasound guided delivery of mRNA to dendritic cells. mRNA expression and the maturation profile of the treated DCs will be evaluated with flow cytometrie. Via OT-I and OT-II assays we can investigate whether CD8+ T-cell and CD4+ T-cell responses are generated in vitro and in vivo.