Project

Doxorubicin-loaded microbubbles for ultrasound controlled destruction of tumor cells

Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
doxorubicin ultrasound microbubbles metastasis
 
Project description

This project evaluates the use of doxorubicin-loaded microbubbles (i.e.: ultrasound responsive gas bubbles) for the destruction of circulating tumor cells. A new type of microbubbles will be designed for this purpose. These microbubbles have a surface loaded with anti-N-Cadherin antibodies that will be used to specifically recognize the circulating metastasis.