RNA therapeutics, including small interfering RNA (siRNA) and messenger RNA (mRNA), are poised to revolutionize medicine. However, despite a clear unmet medical need in many lung diseases, no RNA formulations are currently available for pulmonary use. To unlock the full therapeutic potential of RNA, safe and efficient nanocarriers that can deliver them inside target cells are required. This project aims to develop inhalable nanoformulations for RNA therapeutics, including the repurposing of lung surfactant to promote the cytosolic delivery of RNA in lung-related target cells.