Repurposing lung surfactant protein B for inhalation therapy with RNA therapeutics

01 November 2020 → 31 October 2024
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Respiratory medicine
    • Biopharmaceuticals
    • Biopharmaceutics
  • Engineering and technology
    • Biomaterials
    • Gene and molecular therapy
RNA therapeutics inhalation therapy lipid nanoparticles
Project description

RNA therapeutics, including small interfering RNA (siRNA) and messenger RNA (mRNA), are poised to revolutionize medicine. However, despite a clear unmet medical need in many lung diseases, no RNA formulations are currently available for pulmonary use. To unlock the full therapeutic potential of RNA, safe and efficient nanocarriers that can deliver them inside target cells are required. This project aims to develop inhalable nanoformulations for RNA therapeutics, including the repurposing of lung surfactant to promote the cytosolic delivery of RNA in lung-related target cells.