Project

Bio-inspired nanocomposites of pulmonary surfactant and hydrogel nanoparticles for siRNA inhalation therapy

Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Chemical product design and formulation
    • Biomaterials engineering
Keywords
siRNA nanopartikel lung surfactant asthma
 
Project description

For many respiratory pathologies an unmet therapeutic need exists. Non-invasive pulmonary administration of small interfering RNA (siRNA) enables direct delivery into the lung tissue, but clinical translation is hampered by poor delivery in lung target cells. This project aims to optimize a hybrid nanoformulation composed of pulmonary surfactant for efficient siRNA delivery via inhalation therapy.