Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

Spatial-omics deciphering of cellular and molecular responses to enhanced MYCN/ATR-CHK1 synthetic lethality in high-risk neuroblastoma

A DNA methylation signature as biomarker for prognosis in children with neuroblastoma

A DNA methylation signature as biomarker for prognosis in children with neuroblastoma

A human pluripotent stem cell derived differentiation model for the study of normal and transformed sympathoadrenal progenitors

Analysing and Striking the Sensitivities of Embryonal Tumours

An epigenetic DNA modification signature as a biomarker for prognosis in children with neuroblastoma

An integrated functional proteomics platform for the study of normal development and disease

Array comparative genomic hybridization (Array CGH)

Array comparative genomic hybridization (array CGH) study of submicroscopic genomic rearrangements in patients with unexplained mental retardation.

Beurs EVDS Siebe Loontiens: Unraveling the functionality of PHF6 in normal and malignant T-cell development and its cooperativity with established oncogenes through zebrafish modeling

BRIP1 and FOXM1 controlling replication stress in the neuroblastoma tumor genome

BRIP1 controlling replicative stress in the neuroblastoma tumor genome: functional exploration and zebrafish modelling

Cancer cells and their microenvironment: from gene regulatory networks to therapy

Characterisation and in vivo validation of the therapeutic potential of JAK/STAT antagonists in neuroblastoma

Characterization of the p53 network and exploration of p53-dependent and p53-independent molecular therapy in neuroblastoma

Computational probing of replicative stress resistance and induced G-quadruplex resolving processes in embryonic stem or cancer cells

Construction of a tissue array for 'high-troughput' detection of genomic aberrations and protein profiling in neuroblastoom

Deregulated transcriptional networks of regulatory miRNAs and protein coding genes in the pathogenesis of cancer

Drug resistance in MYC/MYCN driven tumor entities as a consequence of replicative stress induced DNA damage response: an entry point for synthetic lethal drugs

Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma

Dynamic interplay between DNA mehtylation, histone modifications and the activity of super enhancers in the pathogenesis of immature T-ALL

Epigenetic re-activation of T-ALL tumor suppressors under control of TLX1driven enhancer RNAs.

ERAcoSysMed _ JTC 2015    OPTIMIZE NOTE: Optimizing the first-line therapy for aggressive neuroblastoma system by medical strategies against secondary resistance.

European Embryonal Tumor Pipeline

European Network for Cancer research in Children and Adolescents (ENCCA)

Exploring the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia through zebrafish modeling

Exploring the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia through zebrafish modeling

From genes to functional defects in hereditary and malignant diseases

Functional study of the ALK-F1174 mutation in

Genetic and functional study of MYCN target genes in signaling and metabolic pathways and their therapeutic potential in neuroblastoma.

Genetic defects in chromatin regulators in T-cell acute lymphoblastic leukemia

Genome wide screening for methylation defects, nonsense mutaions and tumour-related microRNA expression profiles in neuroblastoma

Genomic analyses of liquid biopsies for diagnosis, monitoring and therapeutic stratification of paediatric cancers.

Genomic and transcriptoomproflering neuroblastoma: identification of prognostic diagnostic expression signatures, unraveling the MYCN transcriptional network and study of the biological role v chromosome 17q gain..

HBP1 as novel therapeutic target in ALK- and MYCN-driven neuroblastoma

Identification and study of NOTCH1 regulated long noncoding RNAs driving T-cell acute lymphoblastic leukemia formation

Identification of critical on mTOR effector pathways in NF1-related tumorigenesis

Identification of deregulated microRNA expression in T-cell acute lymphoblastic leukemia by use of microRNA specific arrayCGH

Identification of direct and miRNA-regulated MYCN target genes and analysis of their involvement in signaling pathways and epigenetic control.

Identification of novel therapeutic targets through multi-level (epi) genomic landscaping of replicative stress resistant neuroblastoma 

Identification of perturbed miRNAs during neuroblasoma development using neuroblasts as normal counterparts

IncuCyte S3 Live-Cell Analysis System

Integrated molecular profiling in neuroblastoma: identification of new molecular therapeutic targets and optimalised prognostic classification

Integration of long noncoding RNAs in miRNA/mRNA regulatory networks in t-cell acute lymphoblastic leukemia

Investigation of the Polycomb-associated RNA sequence space and functional consequences

Long noncoding RNAs in cancer: deciphering the functional role of the dark matter of the human cancer genome

MicroRNA's in neuroblastoma

Molecular signature recognition for improved diagnosis, prognosis and follow-up in neuroblastoma

Molecular therapy of neuroblastoma: a p53-oriented appraoch

MYCN deregulated transcription in neuroblastome: study of direct mRNA and miRNA regulated target genes

Novel combination therapies to combat therapy resistant neuroblastoma: translating pre-clinical investigations to clinical trials

PHF6: a new tumor suppressor gene in T-cell acute lymphoblastic leukemia

Preclinical evaluation of the nutlin molecule RG7112 in neuroblastoma

Preclinical investigation of RRM2-CHK1 combinatorial drugging in neuroblastoma

purchase of a technical platform

Quantitative proteome analysis of MYCN oncoprotein function and identification of molecular therapeutic targets in the neuroblastoma

Reconstructing m(i)RNA regulatory networks implicated in invasion and metastasis in neuroblastoma

Reconstruction of dynamic initiation and progression gene expression regulatory networks in neuroblastoma

Reconstruction of functional molecular networks in ALK mutated neuroblastomas

Reduction of chemotherapy driven late adverse effects through targeted molecular therapies in high-risk pediatric cancers

Replicative stress induced DNA damage response signaling at the crossroad between embryonic stem cells and MYC(N) driven tumours

Research Grant Emmanuel Van de Schueren to Suzanne Vanhauwaert: BRIP1 and BIRC5 as novel therapeutic targets in neuroblastoma

RRM2 controlled replicative stress resistance as a druggable DNA copy number driven cell state in MYC(N) driven cancers

RUNX2 as a driver of poor prognostic early T-cell progenitor leukemia

Selection of driver genes and neuronal differentiation gene modules in neuroblastoma through an integrated genomic analysis

SOX11 as mediator of the adrenergic cell state in neuroblastoma: towards cell precision medicine

STAND UP TO CANCER: Integration of individual cancer genes in signalisation network in pediatric tumors

Startersbeurs EVDS Lisa Depestel: The chromatin modifier PHF6 as adaptor in gene-gating coupled replicative stress in neuroblastoma and T-ALL

Study of neuroblastoma oncogenesis through mRNA and miRNA expression profiling of normal neuroblasts and neuroblastoma stem cells

Targeting the leukemic cancer stem cell in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)

The chromatin modifier BRD3 as a key novel player in DNA repair and vulnerable therapeutic target in neuroblastoma

The chromatin modifier PHF6 as adaptor in gene-gating coupled replicative stress in neuroblastoma and T-ALL

The function of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia

The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient TALL.

The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient T-ALL

The role of BRCA1 as oncogenic replicative stress resistor in MYCN driven neuroblastoma

The role of BRIP1 in MYCN driven neuroblastoma formation: from mechanism to drugging

The role of long noncoding RNAs in T-cell acute lymphoblastic leukemia

The role of microRNA's in the pathogenesis of T-cell acute lymphoblastic leukemia

The role of miRNA expression in normal and malignant T-cel development

The role of miRNAs in neuroblastoma tumor initiation

The role of PHF6 in normal and malign T-cell development.

The role of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia

The role of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia

The role of super-enhancer regulated SOX11 in regulation of SWI/SNF and PRC2 activity in adrenergic neuroblastoma

The role of the ETS transcription factor ETV5 as executer of ALK oncogenic signaling

The role of the SOX11 lineage-dependency factor as epigenetic master regulator in neuroblastoma

The TLX1 epigenetic enhancer lncRNAome in T-cell acute lymphoblastic leukemia

Transcan-2 cofund JTC 2014

Unraveling the role of PHF6 in normal T cell development and T-cell acute leukemia

Unraveling the role of PHF6 in normal T-cell development and T-cell acute leukemia

Unraveling the role of PHF6 in normal T cell development and T-cell acute lymphoblastic leukemia

Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate students

Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate students

Validation of ferroptosis-sensitizing combination therapies in patient-derived neuroblastoma models

Zebrafish modeling of neuroblastoma: novel tools for "accelerated" driver gene discovery and pre-clinical testing

Zebrafish transgenic and patient xenograft transplantation models of pediatric tumors for the pre-clinical drug testing

A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapies

Deciphering the molecular pathogenesis of neuroblastoma through next generation genome analysis

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Identification of causal mutations in patients with unexplained mental retardation and congenital abnormalities by high throughput sequencing of selected candidate genes

Improved outcome prediction of children with neuroblastoma using an integrated m/miRNA and DNA methylation signature (Stichting tegen Kanker)

Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imaging

IVIS Lumina II Bioluminescence camera for laboratory animal research

Longitudinal imaging of cellular dynamics with a biostation IM-Q (microscope with sensitive CCD camera and integrated incubator)

Long noncoding RNAs in cancer: deciphering the functional role of the dark matter of the human cancer genome

Photolithographic DNA printer for massively parallel synthesis of DNA oligonucleotides for spatial - omics and hybrid capture target enrichment applications

Scrutinizing selective Aurora Kinase A inhibition as a novel entry point for synthetic lethality in neuroblastoma

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Spatial transcriptomics exploration of neuroblastoma responses to novel experimental drug treatments targeting the DNA damage response.

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

Study on the envolvement of LEMD3 and neighbouring genes on 12q14 in the pathogenesis of conditions with elevated bone density and growth disordes

Targeting the degradation of proteins involved in neuroblastoma with bivalent ligands.

ThirdGenT: linking third-generation sequencing of (epi)genomes, (epi)transcriptomes and translatomes to life sciences revolutionizes oncology, rare diseases, microbiology, cell and gene technology, developmental and computational biology