Project

Unraveling the role of PHF6 in normal T cell development and T-cell acute lymphoblastic leukemia

Code

178GE0711

Duration

01 October 2010 → 05 January 2016

Funding

Regional and community funding: IWT/VLAIO

Promotor

Franki Speleman

Fellow

Kaat Durinck

Research disciplines

Natural sciences
- Systems biology
Medical and health sciences
- Hematology
- Laboratory medicine
- Medical systems biology
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Morphological sciences
- Oncology

Keywords

systems biology oncology epigenetics

Project description

This research project aims to unravel the role of the tumorsuppressor gene PHF6 in normal T-cell development and T-ALL and identifying the transcriptional networks in which PHF6 is involved. Additional proteomics analyses will be applied to characterize the transcriptional complex in which PHF6 participates. This project aims on longer terms to identify new molecular targets for treatment of T-ALL patients.