Research Explorer

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Researcher

Franki Speleman

Publications & Research Data

Awards & Distinctions

742 Results

2025

Deciphering the neuroblastoma tumor microenvironment using single-cell and spatial omics

Noah BonineKatleen De PreterFranki SpelemanCharlotte Scott

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien HilgertChristophe Van NesteSarah-Lee BekaertFien MartensSuzanne VanhauwaertEllen SandersPeter VerstraelenMartijn RisseeuwEllen M. WesterhoutMark A. Grannetia et al.

A1 Journal Article in SCIENTIFIC REPORTS

2024

HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening

Carolina de Carvalho NunesJasper AnckaertFanny De VloedJolien De WynKaat DurinckJo VandesompeleFranki SpelemanVanessa Vermeirssen

A1 Journal Article in PLOS ONE

Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

Stéphane Van HaverYujie FanSarah-Lee BekaertCeline EveraertWouter Van LoockeVittorio ZanzaniJoke DeschildreInes Fernandez MaestreAdrianna AmaroVanessa Vermeirssen et al.

A1 Journal Article in ISCIENCE

Human pluripotent stem cell modeling, from normal development to neuroblastoma

Stéphane Van HaverFranki SpelemanKatleen De Preter

MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma

Elina FredlundStina AnderssonElien HilgertEzequiel MonferrerGuadalupe Álvarez-HernánSinan KarakayaSiebe LoontiensJan Willem BekTomas GregorEstelle Lecomte et al.

A1 Journal Article in SCIENCE ADVANCES

MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

Alice SalibNisitha JayatillekeJanith A. SeneviratneChelsea MayohKatleen De PreterFranki SpelemanBelamy B. CheungDaniel R. CarterGlenn M. Marshall

A1 Journal Article in ONCOGENE

NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Noah BonineVittorio ZanzaniAnnelies Van HemelrykBavo VannesteChristian ZwickerTinne ThonéSofie RoelandtSarah-Lee BekaertJan KosterIsabelle Janoueix-Lerosey et al.

A1 Journal Article in CELL REPORTS

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus GabrePeter MerseburgerArne ClaeysJoachim SiawSarah-Lee BekaertFranki SpelemanBengt HallbergRuth H PalmerJimmy Van den Eynden

A2 Journal Article in NAR CANCER

2023

A harmonized single-cell transcriptomic atlas of human neuroblastoma

Noah BonineVittorio ZanzaniLiselot MusBavo VannesteChristian ZwickerTinne ThonéSofie RoelandtCécile ThirantAmira KramdiIsabelle Janoueix-Lerosey et al.

Exploration of neuroblastoma xenograft models for the analysis of tumoral cell-free RNA in murine blood plasma

Jill DeleuHanne Van DroogenbroeckJasper AnckaertJilke De WildeKaat DurinckLiselot MusJustine NuytensMuhammad RishfiKathleen SchoofsFranki Speleman et al.

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Jill DeleuHanne Van DroogenbroeckJasper AnckaertAnneleen DecockJilke De WildeKaat DurinckLiselot MusJustine NuytensMuhammad RishfiKathleen Schoofs et al.

A2 Journal Article in EXRNA

Exploring the PHF6-RRM2 axis as a novel entry point for targeted therapy in neuroblastoma using in vitro and in vivo modeling

Lisa DepestelFranki SpelemanKaat Durinck

Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation

Alan Van GoethemJill DeleuNurten YigitCeline EveraertMyrthala Moreno-SmithSanjeev A VasudevanFjoralba ZekaFleur DemuynckEveline BarbieriFranki Speleman et al.

A2 Journal Article in NAR CANCER

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

Jordan F. HastingsSharissa L. LathamAlvin KamiliMadeleine S. WheatleyJeremy Z. R. HanMarie Wong-ErasmusMonica PhimmachanhMax NobisChiara PantarelliAntonia L. Cadell et al.

A1 Journal Article in SCIENCE ADVANCES

Mitotic dysregulation at tumor initiation creates a therapeutic vulnerability to combination anti-mitotic and pro-apoptotic agents for MYCN-driven neuroblastoma

Lei ZhaiAnushree BalachandranRebecca LarkinJanith A. SeneviratneSylvia A. ChungAmit LalwaniShoma TsubotaDominik BeckKenji KadomatsuAnneleen Beckers et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular characterization of SOX11 as multifaceted epigenetic regulator in neuroblastoma

Amber LouwagieFranki SpelemanKatleen De PreterJan Willem Bek

Preclinical evaluation of targeted therapeutic strategies for high-risk neuroblastoma

Carolina de Carvalho NunesFranki SpelemanKaat DurinckVanessa Vermeirssen

Preclinical exploration of the DNA Damage Response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus GabrePeter MerseburgerArne ClaeysJoachim SiawSarah-Lee BekaertFranki SpelemanBengt HallbergRuth H. PalmerJimmy Van den Eynden

SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

Amber LouwagieBieke DecaestekerSarah-Lee BekaertFanny De VloedEllen SandersStéphane Van HaverTim PietersPieter Van VlierbergheS RobertsS Ek et al.

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

2022

Cellular profiling reveals molecular determinants and vulnerabilities of neuroblastoma

Sofia ZanottiWinnok H. De VosFranki Speleman

Cellular senescence in neuroblastoma

Sofia ZanottiBieke DecaestekerSuzanne VanhauwaertBram De WildeWinnok De VosFranki Speleman

A1 Journal Article in BRITISH JOURNAL OF CANCER

Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors

Noah BonineTinne ThonéBavo VannesteLiselot MusCeline EveraertBram De WildeFranki SpelemanCharlotte ScottKatleen De Preter

Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors

Noah BonineTinne ThonéBavo VannesteLiselot MusCeline EveraertBram De WildeFranki SpelemanCharlotte ScottKatleen De Preter

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening

Carolina de Carvalho NunesJasper AnckaertFanny De VloedJolien De WynKaat DurinckJo VandesompeleFranki SpelemanVanessa Vermeirssen

RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Lisa DepestelCarolina de Carvalho NunesLiselot MusIris NelenLouis DelhayeKaylee KellerVolodimir OlexioukFanny De VloedEllen SandersAline Eggermont et al.

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

The adrenergic-specific long non-coding RNA NESPR controls survival of neuroblastoma cells

Louis DelhayeEric de Bony de LavergneDries RombautLim Fang QiBieke DecaestekerLisa DepestelAmber LouwagieEva D'haenePieter-Jan VoldersNurten Yigit et al.

The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples

Ruben Van PaemelCharlotte VandeputteLennart RamanJolien Van ThorreLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeAndries De KokerBjörn Menten et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

A2 Journal Article in NAR CANCER

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

2021

A G316A polymorphism in the ornithine decarboxylase gene promoter modulates MYCN-driven childhood neuroblastoma

Laura D. GambleStefania PurgatoMichelle J. HendersonSimone Di GiacomoAmanda J. RussellPaolo PiginiJayne MurrayEmanuele ValliGiorgio MilazzoFederico M. Giorgi et al.

A1 Journal Article in CANCERS

From DNA copy number gains and tumor dependencies to novel therapeutic targets for high-risk neuroblastoma

Bieke DecaestekerKaat DurinckNadine Van RoyBram De WildeChristophe Van NesteStéphane Van HaverStephen RobertsKatleen De PreterVanessa VermeirssenFranki Speleman

A1 Journal Article in JOURNAL OF PERSONALIZED MEDICINE

Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma

Elena A AfanasyevaMoritz GartlgruberTatsiana RylBieke DecaestekerGeertrui DeneckerGregor MönkeUmut H ToprakAndres FlorezAlica TorkovDaniel Dreidax et al.

A1 Journal Article in LIFE SCIENCE ALLIANCE

MEIS2 is an adrenergic core regulatory transcription factor involved in early initiation of TH-MYCN-driven neuroblastoma formation

Jolien De WynMark W. ZimmermanNina Weichert-LeaheyCarolina de Carvalho NunesBelamy B. CheungBrian J. AbrahamAnneleen BeckersPieter-Jan VoldersBieke DecaestekerDaniel R. Carter et al.

A1 Journal Article in CANCERS

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Sofia ZanottiSuzanne VanhauwaertChristophe Van NesteVolodimir OlexioukJolien Van LaereMarlies VerschuurenJoni Van der MeulenLiselot MusKaat DurinckLaurentijn Tilleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

E. G. GarciaA. VelosoM. L. OliveiraJ. R. AllenS. LoontiensD. BrunsonD. DoC. YanR. MorrisS. Iyer et al.

A1 Journal Article in LEUKEMIA

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

Liselot MusStéphane Van HaverMina PopovicWim TrypsteenSteve LefeverNadja ZeltnerYudelca OgandoEva JacobsGeertrui DeneckerEllen Sanders et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensSara De BrouwerCarolina de Carvalho NunesGeertrui DeneckerFanny De VloedLisa DepestelJuliette RoelsKaren Verboom et al.

The functional annotation and exploration the SOX11 enhanceosome

Amber LouwagieBieke DecaestekerLouis DelhayeEva D'haeneEric de Bony de LavergneVolodimir OlexioukSarah VergultRogier VersteegJan KosterJohan van Nes et al.

2020

A novel TLX1-driven T-ALL zebrafish model : comparative genomic analysis with other leukemia models

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynWouter Van LoockeFinola E. MooreElaine G. GarciaLance BatchelorChiara BorgaBarbara Squiban et al.

A1 Journal Article in LEUKEMIA

Accelerating drug development for neuroblastoma : summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma

Lucas MorenoGiuseppe BaroneSteven G. DuBoisJan MolenaarMatthias FischerJohannes SchulteAngelika EggertGudrun SchleiermacherFranki SpelemanLouis Chesler et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Exploring the role of PHF6 in malignant and normal hematopoiesis through zebrafish modeling

Siebe LoontiensFranki SpelemanPieter Van VlierbergheKaat Durinck

Genetic events contributing to tumour promotion and aggressiveness in high-risk neuroblastoma

Liselot MusFranki SpelemanKaat DurinckBart Roman

Large-scale circular RNA deregulation in T-ALL : unlocking unique ectopic expression of molecular subtypes

Alessia BuratinMaddalena PaganinEnrico GaffoAnna Dal MolinJuliette RoelsGiuseppe GermanoMaria Teresa SiddiValentina SerafinMatthias De DeckerStéphanie Gachet et al.

A1 Journal Article in BLOOD ADVANCES

Long noncoding RNA SILC1 is an upstream regulator of SOX11 in neuroblastoma

Amber LouwagieBieke DecaestekerEva D'haeneLouis DelhayeEric de Bony de LavergneChristophe Van NesteRogier VersteegSara EkBjörn MentenJan Koster et al.

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

SOX11 as guardian of epigenetic plasticity in neuroblastoma

Bieke DecaestekerAmber LouwagieSiebe LoontiensCarolina de Carvalho NunesKaren VerboomJuliette RoelsEva D'haeneRogier VersteegKaat DurinckAnton Henssen et al.

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness

Liselot MusIrina LambertzShana ClaeysCandy KumpsWouter Van LoockeChristophe Van NesteGanesh UmapathyMarica VaapilChristoph BartenhagenGenevieve Laureys et al.

A1 Journal Article in SCIENTIFIC REPORTS

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review

Ruben Van PaemelROSALIE VLUGKatleen De PreterNadine Van RoyFranki SpelemanLeen WillemsTim LammensGenevieve LaureysGudrun SchleiermacherGodelieve AM Tytgat et al.

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : as review (vol 179, pg 191, 2020)

Ruben Van PaemelRoos VlugKatleen De PreterNadine Van RoyFranki SpelemanLeen WillemsTim LammensGenevieve LaureysGudrun SchleiermacherGodelieve A. M. Tytgat et al.

2019

17q gain provides proliferative advantage to human embryonic stem cells under conditions of replicative stress

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

17q gain provides proliferative advantage to human embryonic stem cells under replicative stress

Liselot MusStéphane Van HaverGeertrui DeneckerNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Journal Article in ONCOGENE

Comprehensive pharmacological profiling in neuroblastoma cell lines using Deep Coverage Microscopy (DCM)

Sofia ZanottiMarlies VerschuurenMichael D. HogartyKaat DurinckSuzanne VanhauwaertWinnok H. De VosFranki Speleman

Core regulatory circuitries and epigenetic plasticity in neuroblastoma

Bieke DecaestekerKatleen De PreterFranki Speleman

Deciphering complete cancer transcriptomes from bulk to single cell level

Karen VerboomFranki SpelemanJo VandesompeleKaat Durinck

DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth

Bieke DecaestekerKatleen De PreterFranki Speleman

A2 Journal Article in MOLECULAR & CELLULAR ONCOLOGY

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes

Dries RombautHua-Sheng ChiuBieke DecaestekerCeline EveraertNurten YigitAgathe PelthierIsabelle JanoueixChristophe BartenhagenMatthias FischerStephen Roberts et al.

A1 Journal Article in SCIENTIFIC REPORTS

Long noncoding RNA expression profiling in cancer : challenges and opportunities

Lucia LorenziFrancisco Avila CobosAnneleen DecockCeline EveraertHetty HelsmoortelSteve LefeverKaren VerboomPieter-Jan VoldersFranki SpelemanJo Vandesompele et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

MYCN activation in hTERT immortalized RPE cells as model for oncogene induced senescence

Sofia ZanottiBieke DecaestekerSuzanne VanhauwaertMichael D HogartyVolodimir OlexioukKaat DurinckWinnok De VosFranki Speleman

PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL

Siebe LoontiensKaat DurinckSuzanne VanhauwaertLisa DepestelMariana L OliveiraGivani DewynCharles De BockJoao T BarataDavid LangenauJan Cools et al.

Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing

Charlotte DerpoorterKarl VandepoeleAraceli Diez FraileKatrien VandemeulebroeckeBram De WildeFranki SpelemanNadine Van RoyTim LammensGenevieve Laureys

A1 Journal Article in PEDIATRIC BLOOD & CANCER

Purification of high-quality RNA from a small number of fluorescence activated cell sorted zebrafish cells for RNA sequencing purposes

Siebe LoontiensLisa DepestelSuzanne VanhauwaertGivani DewynCharlotte GistelinckKaren VerboomWouter Van LoockeFilip MatthijssensAndy WillaertJo Vandesompele et al.

A1 Journal Article in BMC GENOMICS

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenL. van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

SMARTer single cell total RNA sequencing

Karen VerboomCeline EveraertNathalie BolducKenneth LivakNurten YigitDries RombautJasper AnckaertMorten VenøJørgen KjemsFranki Speleman et al.

SMARTer single cell total RNA-sequencing

Karen VerboomCeline EveraertNathalie BolducKenneth LivakNurten YigitDries RombautJasper AnckaertSimon LeeMorten VenøJørgen Kjems et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerSara De BrouwerGeertrui DeneckerCarolina de Carvalho NunesVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline Depuydt et al.

Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Zebravis als in-vivo model voor de studie van acute lymfatische leukemie

Siebe LoontiensSuzanne VanhauwaertLisa DepestelKaat DurinckFranki Speleman

A2 Journal Article in ONCOHEMATO

2018

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

Karen VerboomWouter Van LoockePieter-Jan VoldersBieke DecaestekerFrancisco Avila CobosSimon BornscheinCharles E de BockZeynep Kalender AtakEmmanuelle ClappierStein Aerts et al.

A1 Journal Article in HAEMATOLOGICA

A high-throughput 3’ UTR reporter screening identifies microRNA interactomes of cancer genes

Gert Van PeerEvelien MetsShana ClaeysInes De PuntSteve LefeverMaté OngenaertPieter RondouFranki SpelemanPieter MestdaghJo Vandesompele

A1 Journal Article in PLOS ONE

A mechanistic classification of clinical phenotypes in neuroblastoma

S AckermannM CartolanoB HeroA RoderwieserC BartenhagenC RosswogF HertwigT SimonA EggertFranki Speleman et al.

A mechanistic classification of clinical phenotypes in neuroblastoma

S AckermannM CartolanoB HeroA RoderwieserC BartenhagenC RosswogF HertwigT SimonA EggertFranki Speleman et al.

A mechanistic classification of clinical phenotypes in neuroblastoma.

Sandra AckermannMaria CartolanoBarbara HeroAnne WelteYvonne KahlertAndrea RoderwieserChristoph BartenhagenEsther WalterJudith GechtLaura Kerschke et al.

A1 Journal Article in SCIENCE

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

Elaine G GarciaSowmya IyerSara P GarciaSiebe LoontiensRuslan I SadreyevFranki SpelemanDavid M Langenau

A1 Journal Article in LEUKEMIA

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

Fjoralba ZekaAnneleen DecockAlan Van GoethemKatrien VanderheydenFleur DemuynckTim LammensHetty HelsmoortelJoëlle VermeulenRosa NogueraAna P. Berbegall et al.

A1 Journal Article in JCI INSIGHT

Circulating microRNA biomarkers for metastatic neuroblastoma

Fjoralba ZekaAlan Van GoethemTim LammensAnneleen DecockHetty HelsmoortelGenevieve LaureysMichael HogartyEveline BarbieriJason ShohetFrank Berthold et al.

Comprehensive pharmacological profiling in neuroblastoma cell lines using Deep Coverage Microscopy (DCM)

Sofia ZanottiMarlies VerschuurenKaat DurinckFranki SpelemanWinnok De Vos

Comprehensive pharmacological profiling in neuroblastoma cell lines using Deep Coverage Microscopy (DCM)

Sofia ZanottiMarlies VerschuurenKaat DurinckFranki SpelemanWinnok De Vos

Data Descriptor: Meta-mining of copy number profiles of high-risk neuroblastoma tumors

Pauline DepuydtJ KosterV BoevaTD HockingFranki SpelemanG SchleiermacherKatleen De Preter

A1 Journal Article in SCIENTIFIC DATA

DNA copy number imbalances with clinical relevance in cancer : rare events in big data

Pauline DepuydtKatleen De PreterFranki Speleman

Epigenetic regulation of neuroblastoma development

Kaat DurinckFranki Speleman

A1 Journal Article in CELL AND TISSUE RESEARCH

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17Q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenAli RihaniNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheJody J HaighBieke Decaesteker et al.

A1 Journal Article in SCIENTIFIC REPORTS

Genomic amplifications and distal 6q loss : novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtValentina BoevaToby D HockingRobrecht CannoodtInge M AmbrosPeter F AmbrosShahab AsgharzadehEdward F AttiyehValérie CombaretRaffaella Defferrari et al.

A1 Journal Article in JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

Identification of novel drug targets downstream of activated ALK in neuroblastoma

Shana ClaeysFranki SpelemanKatleen De Preter

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Suzanne VanhauwaertBieke DecaestekerSara De BrouwerCarina LeonelliKaat DurinckPieter MestdaghJo VandesompeleKaren SermonGeertrui DeneckerChristophe Van Neste et al.

A1 Journal Article in SCIENTIFIC REPORTS

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

Kristina B EmdalAnna-Kathrine PedersenDorte B Bekker-JensenAlicia LundbyShana ClaeysKatleen De PreterFranki SpelemanChiara FrancavillaJesper V Olsen

A1 Journal Article in SCIENCE SIGNALING

Isolation of high-quality RNA from fluorescent activated cell sorted (FACS) zebrafish cells for RNA sequencing purposes

Siebe LoontiensSuzanne VanhauwaertLisa DepestelGivani DewynCharlotte GistelinckKaren VerboomEls JanssensFilip MatthijssensAndy WillaertJo Vandesompele et al.

LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis

Carmen DorneburgMatthias FischerThomas FE BarthWolfgang Mueller-KlieserBarbara HeroJudith GechtDaniel R CarterKatleen De PreterBenjamin MayerLisa Christner et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

LDHA predicts poor survival in neuroblastoma and its depletion causes aerobic glycolysis-independent inhibition of neuroblastoma cells

C DorneburgM FischerTFE BarthW Mueller-KlieserB HeroJ GechtDR CarterKatleen De PreterFranki SpelemanGM Marshall et al.

Longitudinal evaluation of murine serum microRNAs as biomarkers for neuroblastoma burden and therapeutic TP53 reactivation

Alan Van GoethemNurten YigitCeline EveraertMyrthala Moreno-SmithSanjeev A VasudevanFjoralba ZekaFleur DemunckEveline BarbieriFranki SpelemanPieter Mestdagh et al.

MYCN activation in hTERT immortalized RPE cells as a model for oncogene induced senescence

Sofia ZanottiMarlies VerschuurenMichael D HogartyKaat DurinckWinnok De VosFranki Speleman

MYCN activation in hTERT immortalized RPE cells as model for oncogene induced senescence

Sofia ZanottiBieke DecaestekerMarlies VerschuurenMichael D HogartyKaat DurinckWinnok De VosFranki Speleman

Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN

Chi Yan OoiDaniel R CarterBing LiuChelsea MayohAnneleen BeckersAmit LalwaniZsuzsanna NagySara De BrouwerBieke DecaestekerTzong-Tyng Hung et al.

A1 Journal Article in CANCER RESEARCH

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Promoter-associated proteins of EPAS1 identified by enChIP-MS : a putative role of HDX as a negative regulator

Arash HamidianMarica VaapilKristoffer von StedingkToshitsugu FujitaCamilla U PerssonPontus ErikssonSrinivas VeerlaKatleen De PreterFranki SpelemanHodaka Fujii et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

Shallow whole genome sequencing allows successful copy number profiling in formalin-fixed paraffin-embedded material in neuroblastoma patients

Charlotte VandeputteRuben Van PaemelBram De WildeMalaïka Van der LindenJo Van DorpeBjörn MentenFranki SpelemanNadine Van RoyKatleen De Preter

SOX11 is a transcriptional circuit dosage sensitive transcription factor controlling SWI/SNF components

Bieke DecaestekerSara De BrouwerGeertrui DeneckerFanny De VloedWouter Van LoockeSuzanne VanhauwaertPauline DepuydtMoritz GartlgruberJolien De WynGenevieve Laureys et al.

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M DolmanWouter Van LoockeMoritz GartlgruberCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren Verboom et al.

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease

Bram De WildeAnneleen BeckersSven LindnerKristina AlthoffKatleen De PreterPauline DepuydtPieter MestdaghTom SanteSteve LefeverFalk Hertwig et al.

A2 Journal Article in ONCOTARGET

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline Depuydt et al.

The TLX1 oncogene modules the enhancer RNA landscape in T-ALL

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxYvan SaeysLiesbet MartensPieter Van VlierbergheFranki SpelemanKaat Durinck

TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxLiesbet MartensYvan SaeysPieter Van VlierbergheFranki SpelemanKaat Durinck

Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3’,4’,5’-trimethoxychalcone in rodents

Liselot MusGeertrui DeneckerFranki SpelemanBart Roman

A1 Journal Article in PLOS ONE

2017

BRCA1 hypomethylation causes chemoresistance in high-risk neuroblastoma

A HakkertM EbusJ KosterFranki SpelemanR VersteegH HeynJ Molenaar

BRD3 as a specific vulnerable therapeutic target in neuroblastoma

Jolien De WynKaat DurinckAnneleen BeckersSiebe LoontiensSuzanne VanhauwaertDaniel CarterBelamy ChuengGlenn MarshallKatleen De PreterFrank Westermann et al.

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing

Annelynn WallaertWouter Van LoockeLucie HernandezTom TaghonFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Comprehensive pharmacological profiling in neuroblastoma cell lines using deep coverage microscopy

Sofia ZanottiWinnok De VosFranki Speleman

Deciphering the untranslated message in T-cell acute lymphoblastic leukemia

Annelynn WallaertFranki SpelemanPieter Van VlierberghePieter Rondou

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma

Alan Van GoethemNurten YigitMyrthala Moreno-SmithSanjeev A VasudevanEveline BarbieriFranki SpelemanJason ShohetJo VandesompeleTom Van Maerken

A1 Journal Article in ONCOTARGET

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome

Shana ClaeysGeertrui DeneckerRobrecht CannoodtCandy KumpsKaat DurinckFranki SpelemanKatleen De Preter

A1 Journal Article in ONCOTARGET

Genomic amplifications and distal 6q loss are novel markers for poor survival in high-risk neuroblastoma patients

Pauline DepuydtValentina BoevaToby D HockingRobrecht CannoodtInge M AmbrosPeter F AmbrosShahab AsgharzadehEdward F AttiyehValérie CombaretRaffaella Defferrari et al.

HBP1 is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

Identification of novel, rare markers for poor survival in high-risk neuroblastoma patients by merging and reanalysing existing datasets

Pauline DepuydtValentina BoevaToby HockingRobrecht CannoodtInge AmbrosPeter AmbrosShahab AsgharzadehEdward AttiyehValérie CombaretRaffaella Defferrari et al.

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

Long non-coding RNAs in leukemia : biology and clinical impact

Tim LammensKaat DurinckAnnelynn WallaertFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in CURRENT OPINION IN HEMATOLOGY

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenPauline DepuydtBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarjolijn RenardTom Sante et al.

Shallow whole genome sequencing on circulating cell-free DNA allows reliable noninvasive copy-number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarleen RenardTom SanteTim Lammens et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtPatrick Reynolds et al.

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtJo Vandorpe et al.

Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait

Anneleen DecockMaté OngenaertBram De WildeBénédicte BrichardRosa NogueraFranki SpelemanJo Vandesompele

T-ALL and thymocytes : a message of noncoding RNAs

Annelynn WallaertKaat DurinckTom TaghonPieter Van VlierbergheFranki Speleman

A1 Journal Article in JOURNAL OF HEMATOLOGY & ONCOLOGY

Targeting tachykinin receptors in neuroblastoma

Anton G HenssenAndrea OderskyAnnabell SzymanskyMarleen SeilerKristina AlthoffAnneleen BeckersFranki SpelemanSimon SchäfersKatleen De PreterKathy Astrahanseff et al.

A1 Journal Article in ONCOTARGET

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The FOXM1/BRIP1 axis in replicative stress induced DNA damage response in neuroblastoma : functional exploration and zebrafish modeling

Suzanne VanhauwaertFranki SpelemanKatleen De Preter

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Geertrui DeneckerShana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerBieke DecaestekerEls JanssensCandy KumpsSara De BrouwerIrina LambertzAnnelies FieuwSuzanne VanhauwaertKristina Althoff et al.

The TLX1 oncogene modulates the enhancer RNA landscape in T-ALL

Karen VerboomKaat DurinckMatthias De DeckerWouter Van LoockeFilip MatthijssensJean-Jacques SoulierWouter De LaatTom TaghonPieter Van VlierbergheFranki Speleman

2016

An embryonic stem cell activated FOXM1 transcriptional program marks ultra-high-risk primary neuroblastoma patients for FDI-6 small molecule inhibition

Suzanne VanhauwaertCarina LeonelliSara De BrouwerJolien De WynAnneleen BeckersKaren SermonJo VandesompeleFranki SpelemanKatleen De Preter

Comprehensive pharmacological profiling in neuroblastoma cell lines using high-throughput microscopy

Sofia ZanottiWinnok De VosFranki Speleman

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples

Alan Van GoethemNurten YigitCeline EveraertMyrthala Moreno-SmithLiselot MusEveline BarbieriFranki SpelemanPieter MestdaghJason ShohetTom Van Maerken et al.

A1 Journal Article in SCIENTIFIC REPORTS

Detection of copy number aberrations in cell free DNA from plasma of neuroblastoma patients using shallow massive parallel sequencing

Katleen De PreterNadine Van RoyBjörn MentenAnnelies DheedeneGenevieve LaureysBram De WildeFranki Speleman

Dissecting the NOTCH1 driven transcriptional landscape in T-cell acute lymphoblastic leukemia at single cell level

Karen VerboomKaat DurinckCeline EveraertRobrecht CannoodtPieter Van VlierbergheJo VandesompeleFranki Speleman

DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing

Anneleen DecockMaté OngenaertWim Van CriekingeFranki SpelemanJo Vandesompele

A1 Journal Article in SCIENTIFIC DATA

Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma

Liselot MusShana ClaeysBram De WildeGenevieve LaureysAlan Van GoethemJohannes SchulteKatleen De PreterIrina LambertzFranki Speleman

Dual targeting of ALK and RET: establishing a novel basis for the treatment of neuroblastoma

Liselot MusShana ClaeysBram De WildeGenevieve LaureysAlan Van GoethemJohannes SchulteKatleen De PreterIrina LambertzFranki Speleman

ETV5 functionally connect ALK and CXCR4 signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusEls JanssensNadine Van RoyBram De WildeGenevieve LaureysJan CoolsOlivier De Wever et al.

ETV5 functionally connects ALK and CXCR4 signaling in neuroblastoma

Irina LambertzLiselot MusCandy KumpsShana ClaeysNadine Van RoyBram De WildeGenevieve LaureysJohannes ShulteOlivier De WeverKatleen De Preter et al.

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Exploring the neuroblastoma DNA methylome: from biology to biomarker

Anneleen DecockJo VandesompeleFranki SpelemanMaté Ongenaert

Functional dissection of transcriptional regulation during normal and malignant T-cell development : an integrative (epi)genomic approach

Kaat DurinckFranki SpelemanPieter Van VlierbergheTom Taghon

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis

Daniel R CarterSelina K SuttonMarina PajicJayne MurrayEric O SekyereJamie FletcherAnneleen BeckersKatleen De PreterFranki SpelemanRani E George et al.

A1 Journal Article in MOLECULAR ONCOLOGY

Identification of non-invasive biomarkers for treatment response in neuroblastoma by circulating miRNA profiling

Alan Van GoethemNurten YigitMythala Moreno-SmithCeline EveraertOlivier DelattrePieter MestdaghSaurabh AgarwalEveline BarbieriIsabelle Janoueix-LeroseyJason Shohet et al.

Impact of age and treatment group in childhood high hyperdiploid low risk B-cell acute lymphoblastic leukemia (ALL) : results of the CLG-EORTC 58951 study

Laura ClementStefan SuciuIsabelle LuquetAlina FersterKarima YakoubenAnne UytterbroeckCatherine PaillardNicolas SirventVitor CostaBarbara De Moerloose et al.

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty HelsmoortelSilvia BresolinTim LammensHélène CavéPeter NoellkeAurélie CayeFarzaneh GhazaviAndrica de VriesHenrik HasleVeerle Labarque et al.

A1 Journal Article in BLOOD

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Massive parallel sequencing uncovers chromosomal mosaicism in human embryonic stem cells in both primed and naive culture conditions

Mina PopovicMargot Van der JeughtFranki SpelemanFilip Van NieuwerburghPetra De SutterBjörn MentenBjörn Heindryckx

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Anneleen DecockMaté OngenaertRobrecht CannoodtKimberly VerniersBram De WildeGenevieve LaureysNadine Van RoyAna Pilar BerbegallJulie Bienertova-VaskuNick Bown et al.

A1 Journal Article in ONCOTARGET

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Anneleen DecockMaté OngenaertRobrecht CannoodtKimberly VerniersBram De WildeGenevieve LaureysNadine Van RoyAna Pilar BerbegallJulie Bienertova-VaskuNick Bown et al.

Modeling the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia in zebrafish

Siebe LoontiensKaat DurinckELS JANSSENSSuzanne VanhauwaertPieter RondouJan CoolsCharles De BockInge Van de WalleFinola MooreDavid Langenau et al.

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma

Johannes FabianDesirée OpitzKristina AlthoffMarco LodriniBarbara HeroRuth VollandAnneleen BeckersKatleen De PreterAnneleen DecockNitin Patil et al.

A1 Journal Article in ONCOTARGET

Optimization of a lentiviral inducible CRISPR/Cas9 system to modulate genes essential for sustained growth of cells

Bieke DecaestekerSuzanne VanhauwaertCarina LeonelliFanny De VloedGivani DewynKatleen De PreterFranki Speleman

RPPA-Based protein profiling reveals enhanced PI3K/AKT/mTOR signaling in ETV6/RUNX1-positive acute lymphoblastic leukemia patients with low CD200 expression

Farzaneh GhazaviValentina SerafinPieter RondouTim LammensFranki SpelemanBenedetta AccordiBarbara De MoerloosePieter Van Vlierberghe

RT-qPCR gene expression analysis in zebrafish : preanalytical precautions and use of expressed repetitive elements for normalization

Suzanne VanhauwaertSteve LefeverPaul CouckeFranki SpelemanAnne De PaepeJo VandesompeleAndy Willaert

A1 Journal Article in Methods in Cell Biology

Sensing mutant ALK: Capicua and ETV5 as executors of aberrant ALK-driven MAPK signaling

Irina LambertzLiselot MusCandy KumpsShana ClaeysWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van RoyBram De Wilde et al.

SOX11 acts as part of the MYCN regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerSuzanne VanhauwaertFanny De VloedAnneleen BeckersGenevieve LaureysStein AertsSara EkFranki SpelemanKatleen De Preter

Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait

Anneleen DecockMaté OngenaertBram De WildeBénédicte BrichardRosa NogueraFranki SpelemanJo Vandesompele

A1 Journal Article in EPIGENETICS

Targeting MYCN-driven transcription by BET-bromodomain inhibition

Anton G HenssenKristina AlthoffAndrea OderskyAnneleen BeckersRichard KocheFranki SpelemanSimon SchaeferEmma BellMaike NortmeyerFrank Westermann et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

The BRIP1/FANCJ DNA helicase is a druggable 17q driver oncogene involved in G-quadruplex induced replicative stress resistance in neuroblastoma

Suzanne VanhauwaertAnnelies FieuwCarina LeonelliBieke DecaestekerJolien De WynPauline DepuydtSara De BrouwerNadine Van RoyShuning HeThomas Look et al.

The chromosome 17q super-enhancer landscape in neuroblastoma

Bieke DecaestekerAnton HenssenWouter Van LoockeFrancisco Avila CobosAnneleen BeckersStein AertsJohannes SchulteKatleen De PreterFranki Speleman

The genomic region encompassing the overlapping SOX11 and Lnc-SOX11-1:1 loci exhibits a complex DNA copy number and mRNA expression pattern

Bieke DecaestekerSara De BrouwerRobrecht CannoodtDries RombautWouter Van LoockeAnnelies FieuwFanny De VloedPieter-Jan VoldersBjörn MentenRogier Versteeg et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is an epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis

Bieke DecaestekerFanny De VloedSiebe LoontiensGeertrui DeneckerWouter Van LoockeMoritz GartlgruberDries RombautAnneleen BeckersShana ClaeysAnton Henssen et al.

The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis

Bieke DecaestekerAnton HenssenWouter Van LoockeAnneleen BeckersSiebe LoontiensJohannes SchulteKatleen De PreterFranki Speleman

Unique long non-coding RNA expression signature in ETV6/RUNX1-Driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne UyttebroeckFilip Van Nieuwerburgh et al.

Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertHetty HelsmoortelAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne Uyttebroeck et al.

A1 Journal Article in ONCOTARGET

2015

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

Kristina AlthoffAnneleen BeckersEmma BellMaike NortmeyerTheresa ThorAnnika SprüsselSven LindnerKatleen De PreterAlexandra FlorinLukas C Heukamp et al.

A1 Journal Article in ONCOGENE

An embryonic stem cell activated FOXM1 transcriptional program marks ultra-high-risk primary neuroblastoma patients for FDI-6 small molecule inhibition

Suzanne VanhauwaertCarina LeonelliSara De BrouwerJolien De WynAnneleen BeckersNeuroblastoma Research consortiumJo VandesompeleKaren SermonFranki SpelemanKatleen De Preter

CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol

Farzaneh GhazaviEmmanuelle ClappierTim LammensStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitOdile Minckes et al.

A1 Journal Article in HAEMATOLOGICA

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Differential module analysis in neuroblastoma regulatory networks

Robrecht CannoodtAnneleen BeckersCaroline Van CauwenberghFranki SpelemanKatleen De PreterYvan Saeys

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

ETV5 functionally connect ALK and RET signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusAnneleen BeckersEls JanssensNadine Van RoyGenevieve LaureysJohannes SchulteOlivier De Wever et al.

Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma

Ali RihaniAlan Van GoethemMaté OngenaertSara De BrouwerPieter-Jan VoldersSaurabh AgarwalKatleen De PreterPieter MestdaghJason ShohetFranki Speleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma

Ali RihaniJo VandesompeleFranki SpelemanTom Van Maerken

A1 Journal Article in CANCER CELL INTERNATIONAL

Integrated and cross-species omics analyses identify the DNA damage response pathway as an important vulnerable pathway in aggressive neuroblastoma tumors

Katleen De PreterAnneleen BeckersSuzanne VanhauwaertAnnelies FieuwSara De BrouwerPieter MestdaghJo VandesompeleFranki Speleman

Integrated genomic analysis identifies specific alterations and activation of YAP in relapsed neuroblastoma

A EggertA SchrammJ KoesterY AssenovA KristinaA EngesserY KahlertJ TheissenB HeroF Roels et al.

Massively parallel sequencing technologies in neuroblastoma research

Bram De WildeJo VandesompeleFranki Speleman

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Anneleen DecockMaté OngenaertRobrecht CannoodtKimberly VerniersBram De WildeGenevieve LaureysNadine Van RoyAna Pilar BerbegallJulie Bienertova-VaskuNick Bown et al.

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

miR-135a inhibits cancer stem cell-driven medulloblastoma development by directly repressing Arhgef6 expression

Katayoun HemmesiMario Leonardo SquadritoPieter MestdaghValentina ContiManuela CominelliIgnazio S PirasLucia Sergi SergiSara PiccininRoberta MaestroPietro L Poliani et al.

A1 Journal Article in STEM CELLS

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin

Kristina AlthoffSven LindnerAndrea OderskyPieter MestdaghAnneleen BeckersSarah KarczewskiJan J MolenaarAnna BohrerShirley KnauerFranki Speleman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensNadine Van RoyBruce PoppeFranki SpelemanYves BenoitPieter Van VlierbergheBarbara De Moerloose

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Mutational dynamics between primary and relapse neuroblastomas

Alexander SchrammJohannes KösterYassen AssenovKrstina AlthoffMartin PeiferEllen MahlowAndrea OderskyDaniela BeisserCorinna ErnstAnton G Henssen et al.

A1 Journal Article in NATURE GENETICS

MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma

H DeubzerJ FabianD OpitzK AlthoffM LodriniK AstrahantseffB HeroR VollandAnneleen BeckersKatleen De Preter et al.

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

Anneleen BeckersGert Van PeerDaniel R CarterMoritz GartlgruberCarl HerrmannSaurabh AgarwalHetty HelsmoortelKristina AlthoffJan J MolenaarBelamy B Cheung et al.

A1 Journal Article in CANCER LETTERS

MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation

Anneleen BeckersGert Van PeerDaniel R CarterKristina AlthoffBelamy B CheungJohannes H SchultePieter MestdaghJo VandesompeleGlenn M MarshallKatleen De Preter et al.

A1 Journal Article in ONCOTARGET

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Refinement of the critical 2p25.3 deletion region: the role of MYT1L in intellectual disability and obesity

Nina De RockerSarah VergultDavid KoolenEva JacobsAlexander HoischenSusan ZeesmanBirgitte BangFrédérique BénaNele BockaertErnie Bongers et al.

A1 Journal Article in GENETICS IN MEDICINE

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

André OberthuerDilafruz JuraevaBarbara HeroRuth VollandCarolina SterzRene SchmidtAndreas FaldumYvonne KahlertAnne EngesserShahab Asgharzadeh et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Synergistic combined molecular treatment targeting the HBP1 tumor suppressor gene in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma

Anton HenssenKristina AlthoffRichard KocheAndrea OderskyAnneleen BeckersFranki SpelemanSimon SchaefersKatleen De PreterAlexandra FlorinLukas Heukamp et al.

The chromosome 17q super-enhancer landscape in neuroblastoma

Bieke DecaestekerAnton HenssenWouter Van LoockeAnneleen BeckersStein AertsJohannes SchulteKatleen De PreterFranki Speleman

The chromosome 17q super-enhancer landscape in neuroblastoma

Bieke DecaestekerAnton HenssenWouter Van LoockeAnneleen BeckersStein AertsJohannes SchulteKatleen De PreterFranki Speleman

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

The HBP1 tumour suppressor at multiple regulatory cross roads in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

The long non-coding RNA H19 is regulated by LIN28B

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviS BresolinH CavéA CayeACH de VriesC FlothoV Labarque et al.

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Daniel R CarterJayne MurrayBelamy B CheungLaura GambleJessica KoachJoanna TsangSelina SuttonHeyam KallaSarah SyedAndrew J Gifford et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

Unraveling the MYCN-driven transcriptional landscape of neuroblastoma : a cross-species integrated transcriptome approach

Anneleen BeckersFranki SpelemanKatleen De Preter

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel R CarterAlex CazesBelamy B CheungMarilena De Mariano et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Jonas BethuyneSteven De GieterOlivier ZwaenepoelAbel Garcia-PinoKaat DurinckAdriaan VerhelleGholamreza Hassanzadeh-GhassabehFranki SpelemanRemy LorisJan Gettemans

A1 Journal Article in NUCLEIC ACIDS RESEARCH

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Alex CazesLucille Lopez-DelisleKonstantina TsarovinaCécile Pierre-EugèneKatleen De PreterMichel PeuchmaurAndré NicolasClaire ProvostCaroline Louis-BrennetotRomain Daveau et al.

A1 Journal Article in ONCOTARGET

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjorabla ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes H Schulte et al.

A1 Journal Article in PLOS ONE

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Viraj R SanghviKonstantinos J MavrakisJoni Van der MeulenMichael BoiceAndrew L WolfeMark CartyPrathibha MohanPieter RondouNicholas D SocciYves Benoit et al.

A1 Journal Article in SCIENCE SIGNALING

Characterization of ALK driven molecular networks identifies perturbed RET and cholinergic signaling in neuroblastoma

Irina LambertzCandy KumpsShana ClaeysSven LindlerAnneleen BeckersEls JanssensMarilena De MarianoSara De BrouwerJay GibbonsGenevieve Laureys et al.

Emergence of new ALK mutations at relapse of neuroblastoma

Gudrun SchleiermacherNiloufar JavanmardiVirginie BernardQuentin LeroyJulie CappoThomas Rio FrioGaëlle PierronEve LapoubleValérie CombaretFranki Speleman et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Expressed repeat elements improve RT-qPCR normalization across a wide range of zebrafish gene expression studies

Suzanne VanhauwaertGert Van PeerAli RihaniEls JanssensPieter RondouSteve LefeverAnne De PaepePaul CouckeFranki SpelemanJo Vandesompele et al.

A1 Journal Article in PLOS ONE

Genetisch geïnspireerde toekomstperspectieven voor de therapie van het neuroblastoom

Bram De WildeTom Van MaerkenKatleen De PreterNadine Van RoyGenevieve LaureysJo VandesompeleFranki Speleman

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

Yao-Cheng LinMorgane BooneLeander MeurisIrma LemmensNadine Van RoyArne SoeteJoke ReumersMatthieu MoisseStéphane PlaisanceRadoje Drmanac et al.

A1 Journal Article in NATURE COMMUNICATIONS

Genome-wide methylation analysis unravels differential DNA methylation patterns between (prognostic) neuroblastoma patient subgroups

Anneleen DecockMaté OngenaertAna BerbegallRosa NogueraJayne MurrayMichele HaberRaymond L StallingsJohannes H SchulteValérie CombaretGudrun Schleiermacher et al.

Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma

Eveline BarbieriKatleen De PreterMario CapassoZaowen ChenDanielle M HsuGian Paolo ToniniSteve LefeverJohn HicksRogier VersteegAndrea Pession et al.

A1 Journal Article in CANCER RESEARCH

Integrated genomic analyses for driver gene identification in neuroblastoma

Annelies FieuwFranki SpelemanKatleen De Preter

Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter Van LoockePieter-Jan VoldersMaté OngenaertNadine Van RoyBruce PoppeYves Benoit et al.

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

Hetty HelsmoortelTim LammensNadine Van RoyJan PhilippéPascale De PaepeYves BenoitFranki SpelemanPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma

Ali RihaniTom Van MaerkenBram De WildeFjoralba ZekaGenevieve LaureysKoen NorgaGian Paolo ToniniSimona CocoRogier VersteegRosa Noguera et al.

A1 Journal Article in PEDIATRIC BLOOD & CANCER

LIN28B defines an aggressive subtype of juvenile myelomonocytic leukemia

Hetty HelsmoortelTim LammensFarzaneh GhazaviAurelie CayeHélène CavéChristian FlothoCharlotte NiemeyerJan StarySilvia BresolinRiccardo Masetti et al.

LncRNA profiling in T-cell acute lymphoblastic leukemia predicts a functional connection between lncRNAs and the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

Lost in transcription : emergence of epigenetic drivers and microRNAs in T-cell acute lymphoblastic leukemia

Joni Van der MeulenFranki SpelemanYves Benoit

Mate pair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMarkus J van RoosmalenKaren Duran et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

MYCN safeguards its upregulated expression through negatively controlling its upstream miRNAs

Anneleen BeckersGert Van PeerDaniel CarterBelamy CheungJo VandesompeleGlenn MarshallKatleen De PreterFranki Speleman

Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer

Tom Van MaerkenAli RihaniAlan Van GoethemAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in CANCER LETTERS

Phf6 plays a role in hematopoiesis and thymopoiesis in zebrafish

Els JanssensSuzanne VanhauwaertAndy WillaertKaat DurinckAnne De PaepePieter Van VlierberghePieter RondouFranki Speleman

Prognostic relevance of BTLA/CD200 deletion in pediatric pre-B cell acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensStefan SuciuMarleen BakkusHélène CavéFranki SpelemanYves BenoitBarbara De MoerloosePieter Van Vlierberghe

Promoter DNA-methylation in the TH-MYCN neuroblastoma mouse model

Anneleen BeckersWouter Van LoockeAnneleen DecockMaté OngenaertJo VandesompeleFranki SpelemanKatleen De Preter

Reduced DICER1 functionality in neuroblastoma through reduced expression levels or somatic mutations

Bram De WildeJohannes H SchulteAnneleen BeckersAlexander SchrammAnnelies FieuwDaniel CarterBelamy CheungGlenn MarshallAngelika EggertKatleen De Preter et al.

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Andrew L WolfeKamini SinghYi ZhongPhilipp DreweVinagolu K RajasekharViraj R SanghviKonstantinos J MavrakisMan JiangJustine E RoderickJoni Van der Meulen et al.

A1 Journal Article in NATURE

SOX11 is a lineage-survival oncogene in neuroblastoma

Sara De BrouwerBieke DecaestekerAnneleen BeckersGenevieve LaureysMonique MorrisonRodney StewartFranki SpelemanKatleen De Preter

SOX11 is a lineage-survival oncogene in neuroblastoma

Bieke DecaestekerSara De BrouwerGeneviève LaureysMonique MorrisonRodney StewartFranki SpelemanKatleen De Preter

SOX11 is a lineage-survival oncogene in neuroblastoma

Bieke DecaestekerSara De BrouwerAnneleen BeckersGenevieve LaureysMonique MorrisonRodney StewartFranki SpelemanKatleen De Preter

SOX11 is a lineage-survival oncogene in neuroblastoma

Bieke DecaestekerSara De BrouwerAnneleen BeckersRodney StewartFranki SpelemanKatleen De Preter

Targeted analysis of TP53 pathway SNPs in neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

The epigenetic landscape of T-cell acute lymphoblastic leukemia

Joni Van der MeulenNadine Van RoyPieter Van VlierbergheFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersInge Van de WalleYves BenoitBruce PoppeJo VandesompeleTom TaghonJean Soulier et al.

The H3K27me3 demethylase UTX in normal development and disease

Joni Van der MeulenFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in EPIGENETICS

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

The MYCN/miR-26a-5p/LIN28B regulatory axis controls MYCN-driven LIN28B upregulation in neuroblastoma

Anneleen BeckersAndrew LudwigGert Van PeerDaniel CarterBelamy CheungSara De BrouwerJo VandesompeleKatleen De PreterJason ShohetFranki Speleman

The MYCN/miR-26a-5p/LIN28B regulatory axis explains MYCN driven LIN28B upregulation during mouse neuroblastoma development

Anneleen BeckersDaniel CarterAndrew LudwigGert Van PeerBelamy CheungJo VandesompeleGlenn MarshallJason ShohetKatleen De PreterFranki Speleman

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Kaat DurinckAnnelynn WallaertInge Van de WalleWouter Van LoockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensYves BenoitNadine Van RoyBruce Poppe et al.

A1 Journal Article in HAEMATOLOGICA

The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter VanloockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensMaté OngenaertNadine Van Roy et al.

Time-resolved transcriptome analysis of TH-MYCN driven hyperplastic ganglia and tumors marks BRD3 as a novel candidate oncogene

Anneleen BeckersDaniel CarterCheung BelamyJo VandesompeleGlen MarshallKatleen De PreterFranki Speleman

Uncovering the microRNA landscape in T-cell acute lymphoblastic leukemia

Evelien MetsFranki SpelemanBruce Poppe

Unique lncRNA signatures mark the major T-ALL genetic subgroups

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersYves BenoitBruce PoppePieter MestdaghJo VandesompeleJean SoulierJan Cools et al.

ViVar: a comprehensive platform for the analysis and visualization of structural genomic variation

Tom SanteSarah VergultPieter-Jan VoldersWigard P KloostermanGeert TrooskensKatleen De PreterAnnelies DheedeneFranki SpelemanTim De MeyerBjörn Menten

A1 Journal Article in PLOS ONE

2013

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma

Eveline BarbieriKatleen De PreterMario CapassoPeter JohanssonTsz-Kwong ManZaowen ChenParis StowersGian Paolo ToniniFranki SpelemanJason M Shohet

A1 Journal Article in PLOS ONE

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma

Anton HenssenTheresa ThorAndrea OderskyLukas HeukampNicolai El-HindyAnneleen BeckersFranki SpelemanKristina AlthofSimon SchäfersAlexander Schramm et al.

A1 Journal Article in ONCOTARGET

CLL cells respond to B-cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression

Valerie PedeAns RomboutJOLIEN VERMEIREEvelien NaessensPieter MestdaghNore RobberechtHanne VanderstraetenNadine Van RoyJo VandesompeleFranki Speleman et al.

A1 Journal Article in PLOS ONE

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

Zeynep Kalender AtakValentina GianfeliciGert HulselmansKim De KeersmaeckerArun George DevasiaEllen GeerdensNicole MentensSabina ChiarettiKaat DurinckAnne Uyttebroeck et al.

A1 Journal Article in PLOS GENETICS

Dynamic activity of miR-125b and miR-93 during murine neural stem cell differentiation in vitro and in the subventricular zone neurogenic niche

Annalisa LattanziBernhard GentnerDaniela CornoTiziano Di TomasoPieter MestdaghFranki SpelemanLuigi NaldiniAngela Gritt

A1 Journal Article in PLOS ONE

Dynamic regulation of miRNAs implicated in the MYCN-EZH2 regulatory axis during neuroblastoma tumor initiation and progression in a MYCN mouse model

Anneleen BeckersKatleen De PreterBelamy CheungDaniel CarterGert Van PeerSara De BrouwerPieter MestdaghGenevieve LaureysJo VandesompeleGlenn Marshall et al.

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments

Ali RihaniTom Van MaerkenFilip PattynGert Van PeerAnneleen BeckersSara De BrouwerCandy KumpsEvelien MetsJoni Van der MeulenPieter Rondou et al.

A1 Journal Article in PLOS ONE

Expanding the TLX1 regulate in T-cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Expanding the TLX1-regulome in T cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Focal DNA copy number changes in neuroblastoma target MYCN regulated genes

Candy KumpsAnnelies FieuwPieter MestdaghBjörn MentenSteve LefeverFilip PattynSara De BrouwerTom SanteJohannes Hubertus SchulteAlexander Schramm et al.

A1 Journal Article in PLOS ONE

Genome wide expression, mutation and methylation analysis validates three new mouse models for neuroblastoma targeting MYCN, ALK and LIN28B for pre-clinical studies

Anneleen BeckersBram De WildeMaté OngenaertCandy KumpsJohannes H SchulteJo VandesompeleKatleen De PreterFranki Speleman

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H. SchulteRosa NogueraRaymond L. Stallings et al.

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results

Nicole DastugueStefan SuciuGeneviève PlatFranki SpelemanHélène CavéSandrine GirardMarleen BakkusMarie Pierre PagèsKarima YakoubenBrigitte Nelken et al.

A1 Journal Article in BLOOD

Identification of miRNAs implicated in neuroblastoma tumor initiation and progression through cross-species integrated genomic analysis

Anneleen BeckersKatleen De PreterBelamy CheungSara De BrouwerGert Van PeerPieter MestdaghGenevieve LaureysJo VandesompeleGlenn MarshallFranki Speleman

Identifying and validating DNA methylation biomarkers: the example of neuroblastoma

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Improved outcome prediction of children with neuroblastoma using an integrated miRNA and DNA methylation signature

Anneleen DecockFjoralba ZekaKatleen De PreterFranki SpelemanJo Vandesompele

Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMJ Van RoosmalenK Duran et al.

MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghTom TaghonDavid AvranBarbara De MoerlooseYves BenoitBruce Poppe et al.

miR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A

Kristina AlthoffAnneleen BeckersAndrea OderskyPieter MestdaghJohannes KösterIsabella BrayKenneth BryanJo VandesompeleFranki SpelemanRaymond Stallings et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

S DasK BryanPG BuckleyO PiskarevaIM BrayN FoleyJ RyanJ LynchL CreeveyJ Fay et al.

A1 Journal Article in ONCOGENE

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

JH SchulteS LindnerA BohrerJ MaurerKatleen De PreterSteve LefeverL HeukampS SchulteJ MolenaarR Versteeg et al.

A1 Journal Article in ONCOGENE

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

Nadia C CorreiaKaat DurinckAP LeiteMaté OngenaertPieter RondouFranki SpelemanFJ EnquitaJoão T Barata

A1 Journal Article in LEUKEMIA

Perturbed signaling pathways in neuroblastoma : from MYCN to ALK and back

Candy KumpsFranki SpelemanKatleen De Preter

Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma

Tom Van MaerkenAli RihaniAlan Van GoethemAnne De PaepeFranki SpelemanJo Vandesompele

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

The MYCN driven murine and human neuroblastoma methylome and dynamic regulation of chromatin regulators as a guide for epigenetic therapy

Anneleen BeckersAnneleen DecockBelamy CheungDaniel CarterGert Van PeerSara De BrouwerGenevieve LaureysJo VandesompeleJohannes H SchulteGlenn Marshall et al.

2012

ALK(F1174L) is a driving oncogene of neuroblastoma in transgenic mice

Johannes SchulteLukas HeukampTheresa ThorCandy KumpsKatleen De PreterBram De WildeJo VandesompeleFranki SpelemanAlexander SchrammAngelika Eggert

Cancer gene prioritization for targeted resequencing using fitSNP scores

Annelies FieuwBram De WildeFranki SpelemanJo VandesompeleKatleen De Preter

A1 Journal Article in PLOS ONE

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

Jan J MolenaarJan KosterMarli E EbusPeter van SluisEllen M WesterhoutKatleen De PreterDavid GisselssonIingrid ØraFranki SpelemanHuib N Caron et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma

Sara De BrouwerPieter MestdaghIrina LambertzFilip PattynAnne De PaepeFrank WestermannChristina SchroederJohannes H SchulteAlexander SchrammKatleen De Preter et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

A SchrammB SchoweK FielitzM HeilmannM MartinT MarschallJ KösterJo VandesompeleJoëlle VermeulenKatleen De Preter et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

A1 Journal Article in GENOME BIOLOGY

Genomic profiling of MYCN and ALKF1174L transgenic neuroblastoma mouse models provides insights into the dynamic process of tumor formation

Katleen De PreterAnneleen BeckersCandy KumpsPieter MestdaghAngelika EggertJo VandesompeleFranki SpelemanJohannes H Schulte

High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature

Ann JanssensNadine Van RoyBruce PoppeLucien NoensJan PhilippéFranki SpelemanFritz Offner

A1 Journal Article in EUROPEAN JOURNAL OF HAEMATOLOGY

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

Annelies FieuwCandy KumpsAlexander SchrammFilip PattynBjörn MentenFrancesca AntonacciPeter SudmantJohannes H SchulteNadine Van RoySarah Vergult et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

Fieke LamersLinda SchildJan KosterFranki SpelemanIngrid ØraEllen M WesterhoutPeter van SluisRogier VersteegHuib N CaronJan J Molenaar

A1 Journal Article in BMC CANCER

Improved risk stratification and outcome prediction in children with average risk 1 precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

Improved risk-stratification and outcome prediction in children with average risk precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization

Mado VandewoestyneCandy KumpsKatrien SwertsBjörn MentenTim LammensJan PhilippéKatleen De PreterGenevieve LaureysNadine Van RoyFranki Speleman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

Jan J MolenaarRaquel Domingo-FernándezMarli E EbusSven LindnerJan KosterKsenjia DrabekPieter MestdaghPeter van SluisLinda J ValentijnJohan van Nes et al.

A1 Journal Article in NATURE GENETICS

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

A SprüsselJH SchulteS WeberM NeckeK HändschkeT ThorKW PajtlerA SchrammK KönigL Diehl et al.

A1 Journal Article in LEUKEMIA

Mapping the neuroblastoma epigenome

Maté OngenaertAnneleen DecockJo VandesompeleFranki Speleman

Mapping the neuroblastoma epigenome: perspectives for improved prognostic biomarkers

Maté OngenaertAnneleen DecockGenevieve LaureysJo VandesompeleFranki Speleman

Mapping the neuroblastoma epigenome: perspectives for improved prognostic biomarkers

Maté OngenaertAnneleen DecockJo VandesompeleFranki Speleman

Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Sarah VergultEllen Van BinsbergenTom SanteSilke NowakOlivier VanakkerKathleen ClaesBruce PoppeNathalie Van der AaMJ Van RoosmalenK Duran et al.

MiR-137 is epigenetically silenced in MYCN amplified neuroblastoma and targets the polycomb repressive complex 2 (PRC2) component EZH2

Anneleen BeckersMaté OngenaertAnneleen DecockCandy KumpsFilip PattynPieter MestdaghJohannes H. SchulteFranki SpelemanKatleen De Preter

MiR-137 is epigenetically silenced in MYCN amplified neuroblastomas and targets the polycomb repressive complex 2 (PRC2) component EZH2

Anneleen BeckersMaté OngenaertAnneleen DecockCandy KumpsFilip Pattynthe Neuroblastoma Research Consortium (NRC)Pieter MestdaghJohannes H SchulteFranki SpelemanKatleen De Preter

MYCN directly regulates long non-coding RNA expression in neuroblastoma

Pieter MestdaghJohannes SchulteFilip PattynFrank WestermannGenevieve LaureysFranki SpelemanJo Vandesompele

N-Cadherin in neuroblastoma disease : expression and clinical significance

Tim LammensKatrien SwertsLara DeryckeANNEMIE DE CRAEMERSara De BrouwerKatleen De PreterNadine Van RoyJo VandesompeleFranki SpelemanJan Philippé et al.

A1 Journal Article in PLOS ONE

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

Annette KünkeleKatleen De PreterLukas HeukampTheresa ThorKristian W PajtlerWolfgang HartmannMichel MittelbronnMichael A GrotzerHedwig E DeubzerFranki Speleman et al.

A1 Journal Article in NEURO-ONCOLOGY

PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies

François P DuhouxGeneviève AmeyeCarmen P Montano-AlmendrasKhadija BahloulaMarie J MozziconacciSophy LaibeIwona WlodarskaLucienne MichauxPascaline TalmantSteven Richebourg et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Promoter methylation analysis identifies prognostic methylation biomarkers in neuroblastoma

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project

G SchleiermacherV MosseriWB LondonJM MarisGM BrodeurE AttiyehM HaberJ KhanA NakagawaraFranki Speleman et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Semi-high-throughput epigenetic validation using MSP on a real-time qPCR platform

Anneleen DecockMaté OngenaertJo VandesompeleFranki Speleman

Study of the miRNome of childhood myelodysplastic syndrome

Hetty HelsmoortelTim LammensNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitFranki SpelemanBarbara De Moerloose

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation

David NittnerIrina LambertzFrederic ClermontPieter MestdaghCorinna KöhlerSøren Jensby NielsenAart JochemsenFranki SpelemanJo VandesompeleMichael A Dyer et al.

A1 Journal Article in NATURE CELL BIOLOGY

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice

Lukas C HeukampTheresa ThorAlexander SchrammKatleen De PreterCandy KumpsBram De WildeAndrea OderskyMartin PeiferSven LindnerAnnika Spruessel et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Transcriptional miRNA/mRNA networks in neuroblastoma: from integrative analysis to molecular therapy

Sara De BrouwerFranki SpelemanKatleen De Preter

2011

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Konstantinos J MavrakisJoni Van der MeulenAndrew L WolfeXiaoping LiuEvelien MetsTom TaghonAly A KhanManu SettyPieter RondouPeter Vandenberghe et al.

A1 Journal Article in NATURE GENETICS

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPieter RondouPeter Vandenberghe et al.

A multilocus technique for risk evaluation of patients with neuroblastoma

Inge M AmbrosBettina BrunnerGerhard AignerClare BedwellKlaus BeiskeJean BénardNick BownValerie CombaretJerome CouturierRaffaella Defferrari et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Cooperative miRNA mediated FBXW7 suppression contributes to T-cell lymphoblastic leukemogenesis

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPeter VandenbergheEric Delabesse et al.

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Exploring the neuroblastoma methylome using MBD2-seq

Maté OngenaertAnneleen DecockJo VandesompeleFranki Speleman

Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist Nutlin-3

Tom Van MaerkenAli RihaniDaniel DreidaxSarah De ClercqNurten YigitJean-Christophe MarineFrank WestermannAnne De PaepeJo VandesompeleFranki Speleman

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

Genomic microarrays: challenges and opportunities: five years experience in a diagnostic setting

Sarah VergultKaren BuysseBARBARA DELLE CHIAIESandra JanssensOlivier VanakkerRudy Van CosterAnne De PaepeFranki SpelemanBjörn Menten

High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma

Johannes H SchulteHagen S BachmannBent BrockmeyerKatleen De PreterAndré OberthürSandra AckermannYvonne KahlertKristian PajtlerJessica TheissenFrank Westermann et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

J BanG JugPieter MestdaghR SchwentnerM KauerDNT AryeeK-L SchaeferF NakataniK ScotlandiM Reiter et al.

A1 Journal Article in ONCOGENE

Identification of a new rare recurrent 1q42.2-qter deletion in neuroblastoma

Annelies FieuwCandy KumpsAlexander SchrammBjörn MentenJohannes SchulteNadine Van RoySarah VergultRosa NogueraRogier VersteegR Stallings et al.

Mapping the neuroblastoma epigenome

Maté OngenaertAnneleen DecockJo VandesompeleFranki Speleman

Measurable impact of RNA quality on gene expression results from quantitative PCR

Joëlle VermeulenKatleen De PreterSteve LefeverJustine NuytensFanny De VloedStefaan DerveauxJan HellemansFranki SpelemanJo Vandesompele

A1 Journal Article in NUCLEIC ACIDS RESEARCH

MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival

EA AfanasyevaPieter MestdaghCandy KumpsJo VandesompeleV EhemannJ TheissenMark ZapatkaBenedikt BrorsL SavelyevaV Sagulenko et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

MicroRNA-based diagnosis, prognosis and treatment of paediatric acute lymphoblastic leukaemia

Tim LammensFarzaneh GhazaviFranki SpelemanYves BenoitBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

miRNA Expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples

Katleen De PreterPieter MestdaghJoëlle VermeulenFjoralba ZekaAlene NaranjoIsabella BrayVictoria CastelCaifu ChenElzbieta DrozynskaAngelika Eggert et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Molecular portraits of non-coding RNAs in neuroblastoma

Pieter MestdaghJo VandesompeleFranki Speleman

Neuroblastoma epigenetics : from candidate gene approaches to genome-wide screenings

Anneleen DecockMaté OngenaertJo VandesompeleFranki Speleman

A1 Journal Article in EPIGENETICS

Neuroblastoma genetics and phenotype: a tale of heterogeneity

Franki SpelemanKatleen De PreterJo Vandesompele

A1 Journal Article in SEMINARS IN CANCER BIOLOGY

New options for molecular therapy of neuroblastoma: from p53 to gene therapy

Tom Van MaerkenFranki SpelemanJo Vandesompele

Pharmacological activation of p53 and gene therapy as emerging treatment options for neuroblastoma

Tom Van MaerkenAli RihaniAnne De PaepeJo VandesompeleFranki Speleman

A2 Journal Article in BELGIAN JOURNAL OF MEDICAL ONCOLOGY

PHF6 mutations in adult acute myeloid leukemia

Pieter Van VlierbergheJ PatelO Abdel-WahabC LobryCV HedvatM BalbinC NicolasAR PayerHF FernandezMS Tallman et al.

A1 Journal Article in LEUKEMIA

Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies

François P DuhouxGeneviève AmeyeVirginie LambotChristian HerensFrédéric LambertSophie RaynaudIwona WlodarskaLucienne MichauxCatherine Roche-LestienneElise Labis et al.

A1 Journal Article in PLOS ONE

Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development

Joni Van der MeulenEvelien MetsPieter MestdaghPeter PipelersTom TaghonDavid Camacho TrujilloDavid AvranGert Van PeerNadine Van RoyOlivier Thas et al.

Selectieve inhibitie van de p53–MDM2 interactie door nutlin-3 als een nieuwe therapeutische strategie voor neuroblastoom

Tom Van MaerkenAli RihaniAnne De PaepeJo VandesompeleFranki Speleman

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

Semi-high throughput epigenetic validation using MSP on a real-time qPCR platform

Anneleen DecockMaté OngenaertJo VandesompeleFranki Speleman

Semi-high throughput epigenetic validation using MSP on a real-time qPCR platform

Anneleen DecockMaté OngenaertJo VandesompeleFranki Speleman

The microRNA body map : dissecting microRNA function through integrative genomics

Pieter MestdaghSteve LefeverFilip PattynDana RidzonErik FredlundAnnelies FieuwMaté OngenaertJoëlle VermeulenAnne De PaepeLinda Wong et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

Pieter MestdaghAna-Karin BostromFrancis ImpensErik FredlundGert Van PeerPaquito De AntonelisKristoffer Von StedingkBart GhesquièreStefanie SchulteMichael Dews et al.

2010

Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature

Katleen De PreterJoëlle VermeulenB BrorsO DelattreA EggertM FischerI Janoueix-LeroseyC LavarinoJM MarisJ Mora et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

Johannes SchulteBenjamin SchowePieter MestdaghLars KaderaliPrabhav KalaghatgiStefanie SchlierfJoëlle VermeulenBent BrockmeyerKristian PajtlerTheresa Thor et al.

Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

Johannes H SchulteBenjamin SchowePieter MestdaghLars KaderaliPrabhav KalaghatgiStefanie SchlierfJoëlle VermeulenBent BrockmeyerKristian PajtlerTheresa Thor et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

An integrated genomics approach unravels a role for micro-RNAs in EWS-FLI1 driven Ewings sarcoma pathogenesis

Heinrich KovarPieter MestdaghMax KauerJozef BanSven BilkeRaphaela SchwentnerFranki SpelemanPaul MeltzerJo Vandesompele

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghErik FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterAlexander Schramm et al.

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghE FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterA Schramm et al.

A1 Journal Article in ONCOGENE

Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma

Patrick G BuckleyLeah AlcockKenneth BryanIsabella BrayJohannes H SchulteAlexander SchrammAngelika EggertPieter MestdaghKatleen De PreterJo Vandesompele et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas

Nancy Van DammePhilippe DeronNadine Van RoyPieter DemetterAlain BolsJo Van DorpeFilip BaertJean-Luc Van LaethemFranki SpelemanPatrick Pauwels et al.

A1 Journal Article in BMC CANCER

Giant axonal neuropathy caused by compound heterozygosity for a maternally inherited microdeletion and a paternal mutation within the GAN gene

Karen BuysseSarah VergultSilke MusscheChantal Ceuterick-De GrooteFranki SpelemanBjörn MentenWilly LissensRudy Van Coster

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

High expression of the ALK receptor tyrosine kinase precedes mutation as a determining factor of unfavourable phenotype in primary neuroblastoma

Johannes SchulteHagen BachmannBent BrockmeyerSandra NowackiYvonne KahlertAndre OberthurKatleen De PreterKristian PajtlerJessica TheissenFrank Westermann et al.

Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

An De WeerBruce PoppeSarah VergultPieter Van VlierbergheMarjan PetrickRobrecht De BockYves BenoitLucien NoensAnne De PaepeNadine Van Roy et al.

A1 Journal Article in PLOS ONE

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

Sara De BrouwerKatleen De PreterCandy KumpsPiotr ZabrockiMichael PorcuEllen M WesterhoutArjan LakemanJo VandesompeleJasmien HoebeeckTom Van Maerken et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

methGraph: A genome visualization tool for PCR-based methylation assays

Steve LefeverJasmien HoebeeckFilip PattynGábor TusnádyAnne De PaepeFranki SpelemanTamás ArányiJo Vandesompele

A1 Journal Article in EPIGENETICS

Microrna expression in pediatric precursor-B acute lymphoblastic leukemia: biology, classification and prognosis

Tim LammensBarbara De MoerlooseJonas Van BaelenJoni Van der MeulenPieter MestdaghBruno VerhasseltJan PhilippéFranki SpelemanYves Benoit

mir-17-92 is a master regulator of TGFβ-pathway activity in neuroblastoma

Pieter MestdaghAnna-Karin BöstromFrancis ImpensErik FredlundKris Von StedingkBart GhesquièreStefanie SchlierfJohannes SchulteAlexander SchrammKris Gevaert et al.

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

L MaJ YoungH PrabhalaE PanPieter MestdaghD MuthJ Teruya-FeldsteinF ReinhardtTT OnderS Valastyan et al.

A1 Journal Article in NATURE CELL BIOLOGY

Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma

Candy KumpsNadine Van RoyL HeyrmanD GoossensJ Del-FaveroR NogueraJo VandesompeleFranki SpelemanKatleen De Preter

A1 Journal Article in BMC GENOMICS

MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors

Pieter MestdaghE FredlundFilip PattynJH SchulteD MuthJoëlle VermeulenCandy KumpsS SchlierfKatleen De PreterNadine Van Roy et al.

A1 Journal Article in ONCOGENE

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

E ClappierS ColletteN GrardelS GirardL SuarezG BrunieS KaltenbachK YakoubenF MazingueA Robert et al.

A1 Journal Article in LEUKEMIA

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheTeresa PalomeroHossein KhiabanianJoni Van der MeulenMireia CastilloNadine Van RoyBarbara De MoerlooseJan PhilippéSara Gonzalez-GarciaMaria L Toribio et al.

A1 Journal Article in NATURE GENETICS

Predicting outcomes for children with neuroblastoma

Joëlle VermeulenKatleen De PreterPieter MestdaghGenevieve LaureysFranki SpelemanJo Vandesompele

A1 Journal Article in DISCOVERY MEDICINE

Prognostic impact of gene expression-based classification for neuroblastoma

Andre OberthuerBarbara HeroFrank BertholdDilafruz JuraevaAndreas FaldumYvonne KahlertShahab AsgharzadehRobert SeegerPaola ScaruffiGian Paolo Tonini et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Report of an apparently balanced translocation disrupting the AUTS2 gene in a patient with developmental delay

Sarah VergultGeert MortierFranki SpelemanBjörn Menten

Report of an apparently balanced translocation disrupting the AUTS2 gene in a patient with developmental delay

Sarah VergultGeert MortierFranki SpelemanBjörn Menten

Report of an apparently balanced translocation disrupting the AUTS2 gene in a patient with developmental delay

Sarah VergultGeert MortierFranki SpelemanBjörn Menten

Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo

Kristen N RichardsPatrick A Zweidler-McKayNadine Van RoyFranki SpelemanJesus TrevinoPeter E ZageDennis PM Hughes

A1 Journal Article in CANCER

The miR-17-92 MicroRNA Cluster regulates multiple components of the TGF-beta Pathway in neuroblastoma

Pieter MestdaghAnna-Karin BostromFrancis ImpensErik FredlundGert Van PeerPasqualino De AntonellisKristoffer von StedingkBart GhesquièreStefanie SchulteMichael Dews et al.

A1 Journal Article in MOLECULAR CELL

The miRNA body map: dissecting miRNA function through integrative genomics

Pieter MestdaghSteve LefeverFilip PattynDana RidzonErik FredlundAnnelies FieuwJoëlle VermeulenAnne De PaepeLinda WongFranki Speleman et al.

The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors

Deborah CastellettiGiulio FiaschettiValeria Di DatoUrs ZieglerCandy KumpsKatleen De PreterMassimo ZolloFranki SpelemanTarek ShalabyDaniela De Martino et al.

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

The TLX1 oncogene drives aneuploidy in T cell transformation

Kim De KeersmaeckerPedro J RealGiusy Della GattaTeresa PalomeroMaria Luisa SulisValeria ToselloPieter Van VlierbergheKelly BarnesMireia CastilloXavier Sole et al.

A1 Journal Article in NATURE MEDICINE

Toepassing van microarray-analyse in de genetische diagnostiek

Björn MentenKaren BuysseGeert MortierAnne De PaepeFranki Speleman

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2009

59-gene prognostic signature sub-stratifies high-risk neuroblastoma patients

Joëlle VermeulenKatleen De PreterGenevieve LaureysFranki SpelemanJo Vandesompele

Editorial material

A novel and universal method for microRNA RT-qPCR data normalization

Pieter MestdaghPieter Van VlierbergheAn De WeerDaniel MuthFrank WestermannFranki SpelemanJo Vandesompele

A1 Journal Article in GENOME BIOLOGY

Aberrant methylation of candidate tumor suppressor genes in neuroblastoma

Jasmien HoebeeckEvi MichelsFilip PattynValerie CombaretJoelle VermeulenNurten YigitClaire HoyouxGenevieve LaureysAnne De PaepeFranki Speleman et al.

A1 Journal Article in CANCER LETTERS

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma

Tom Van MaerkenDevanand SarkarFranki SpelemanPaul DentWilliam A. WeissPaul B. Fisher

A1 Journal Article in Journal of Cellular Physiology

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53

Tom Van MaerkenLiesbeth FerdinandeJasmien TaildemanIrina LambertzNurten YigitLiesbeth VercruysseAli RihaniMartin MichaelisJindrich CinatlClaude Cuvelier et al.

A1 Journal Article in JOURNAL OF THE NATIONAL CANCER INSTITUTE

Array comparative genomic hybridization and flow cytometry analysis of spontaneous abortions and mors in utero samples

Björn MentenKatrien SwertsBARBARA DELLE CHIAIESandra JanssensKaren BuysseJan PhilippéFranki Speleman

A1 Journal Article in BMC MEDICAL GENETICS

Challenges for CNV interpretation in clinical molecular karyotyping: lessons learned from a 1001 sample experience

Karen BuysseBARBARA DELLE CHIAIERudy Van CosterBart LoeysAnne De PaepeGeert MortierFranki SpelemanBjörn Menten

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles

Jasmien HoebeeckBram De WildeEvi MichelsValerie CombaretNurten YigitEls De SmetNadine Van RoyEric StanbridgeNing RuGenevieve Laureys et al.

A1 Journal Article in CANCER INVESTIGATION

Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs

Pieter Van VlierbergheAn De WeerPieter MestdaghTom FeysKatleen De PreterAnne De PaepeKathleen LambeinJo VandesompeleNadine Van RoyBruno Verhasselt et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

CRYPTIC 9P24 MICRODELETIONS COVERING HSA-MIR-101-2 ARE RECURRENT IN HEMATOLOGICAL MALIGNANCIES

K van RoosbroeckI LahortigaJF FerreiroJoni Van der MeulenP VandenbergheJ CoolsFranki SpelemanP MarynenI Wlodarska

Disease-Causing 7.4 kb Cis-Regulatory Deletion Disrupting Conserved Non-Coding Sequences and Their Interaction with the FOXL2 Promotor: Implications for Mutation Screening

Barbara D'haeneC AttanasioDIANE BEYSENJ DostieE LemireP BouchardM FieldK JonesB LorenzBjörn Menten et al.

A1 Journal Article in PLOS GENETICS

Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2

An De WeerPieter MestdaghKatleen De PreterJoni Van der MeulenPieter Van VlierbergheTom Van MaerkenNadine Van RoyMarta JeisonIsaac YanivBarbara Cauwelier et al.

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis

Tom Van MaerkenJo VandesompeleAli RihaniAnne De PaepeFranki Speleman

A1 Journal Article in Cell Death & Differentiation

External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data

Joëlle VermeulenFilip PattynKatleen De PreterLiesbeth VercruysseStefaan DerveauxPieter MestdaghSteve LefeverJan HellemansFranki SpelemanJo Vandesompele

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome

BWM van BonHC MeffordBjörn MentenDA KoolenAJ SharpWM NillesenJW InnisTJL de RavelCL MercerM Fichera et al.

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Gebruik van genexpresieanalyse in de aanpak van neuroblastoom bij kinderen

Joëlle VermeulenKatleen De PreterPieter MestdaghFilip PattynAnne De PaepeNadine Van RoyGenevieve LaureysFranki SpelemanJo Vandesompele

A4 Journal Article in ONCO (NEDERLANDSE ED.)

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

A MuratiC GervaisN CarbucciaP FinettiN CerveraJ AdelaideS StruskiE LippertF MugneretI Tigaud et al.

A1 Journal Article in LEUKEMIA

Improved Detection of Chromosomal Abnormalities in Chronic Lymphocytic Leukemia by Conventional Cytogenetics Using CpG Oligonucleotide and Interleukin-2 Stimulation: A Belgian Multicentric Study

N PutP KoningsK RackM JamarNadine Van RoyJM LiboutonP VannuffelD SartenaerG AmeyeFranki Speleman et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Improved outcome prediction of children with neuroblastoma using a multigene expression signature

Joëlle VermeulenJo VandesompeleFranki Speleman

International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

PF AmbrosIM AmbrosGM BrodeurM HaberJ KhanA NakagawaraG SchleiermacherFranki SpelemanR SpitzWB London et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

International consensus for neuroblastoma molecular diagnostics: Report from the international neuroblastoma risk grouping (INRG) Biology committee

PF AmbrosIM AmbrosGM BrodeurM HaberJ KhanA NakagawaraG SchleiermacherFranki SpelemanR SpitzWB London et al.

Mapping of 5q35 chromosomal rearrangements within a genomically unstable region (vol 45, pg 672, 2008)

Karen BuysseA CrepelBjörn MentenFilip PattynF AntonacciJA VeltmanLA LarsenZ TumerA de KleinI van de Laar et al.

Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds

Katleen De PreterSara De BrouwerTom Van MaerkenFilip PattynA SchrammA EggertJo VandesompeleFranki Speleman

A1 Journal Article in CLINICAL CANCER RESEARCH

MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Joni Van der MeulenPieter Van VlierberghePieter MestdaghJo VandesompeleBruce PoppeNadine Van RoyTom TaghonJean PlumB. CauwelierDLD Selleslag et al.

Modeling neuroblastomagenesis from neural crest stem cells in vitro and in vivo

J SchulteA BohrerE MahlowJ MaurerH SchorleKatleen De PreterJo VandesompeleFranki SpelemanS SchlierfK Pajtler et al.

MODULATION OF MIR-449A EXPRESSION DECREASES CELL VIABILITY, INCREASES APOPTOSIS AND INDUCES DIFFERENTIATION IN EVI1 DEREGULATED LEUKEMIA CELLS

An De WeerBruce PoppePieter MestdaghKatleen De PreterPieter Van VlierbergheNadine Van RoyM JeisonB CauwelierBruno VerhasseltJan Philippé et al.

Molecular karyotyping: a powerful tool for the study of genomic defects in patients with mental retardation

Karen BuysseFranki SpelemanGeert Mortier

Myhre syndrome: in search of the causal gene

Sarah VergultMarleen SimonBARBARA DELLE CHIAIEAli RihaniFranki SpelemanGeert MortierBjörn Menten

Myhre syndrome: in search of the causal gene

Sarah VergultMarleen SimonBARBARA DELLE CHIAIEAli RihaniFranki SpelemanGeert MortierBjörn Menten

Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma

I Janoueix-LeroseyG SchleiermacherE MichelsV MosseriA RibeiroD LequinJ VermeulenJ CouturierM PeuchmaurA Valent et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

Joëlle VermeulenKatleen De PreterArlene NaranjoLiesbeth VercruysseNadine Van RoyJan HellemansKatrien SwertsSophie BravoPaolo ScaruffiGian Paolo Tonini et al.

A1 Journal Article in LANCET ONCOLOGY

Risk estimation of neuroblastoma patients by gene expression based classification

M FischerA OberthuerB BrorsF WestermannJ TheissenS AsgharzadehR SeegerP ScaruffiGP ToniniI Janoueix-Lerosey et al.

RNA pre-amplification enables large-scale RT-qPCR gene-expression studies on limiting sample amounts

Joëlle VermeulenStefaan DerveauxSteve LefeverEls De SmetKatleen De PreterNurten YigitAnne De PaepeFilip PattynFranki SpelemanJo Vandesompele

A2 Journal Article in BMC RESEARCH NOTES

RTPrimerDB : the portal for real-time PCR primers and probes

Steve LefeverJo VandesompeleFranki SpelemanFilip Pattyn

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Smoothing waves in array CGH tumor profiles

Mark A van de WielRebecca BrosensPaul HC EilersCandy KumpsGerrit A MeijerBjörn MentenErik SistermansFranki SpelemanMarieke E TimmermanBauke Ylstra

A1 Journal Article in BIOINFORMATICS

The 12q14 microdeletion syndrome: additional patients and further evidence that HMGA2 is an important genetic determinant for human height

Karen BuysseWilliam ReardonLakshmi MehtaTeresa CostaCarrie FagerstromDaniel J KingsburyGeorge AnadiotisBarbara C McGillivrayJan HellemansNicole de Leeuw et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

The emerging molecular pathogenesis of neuroblastoma : implications for improved risk assessment and targeted therapy

Nadine Van RoyKatleen De PreterJasmien HoebeeckTom Van MaerkenFilip PattynPieter MestdaghJoëlle VermeulenJo VandesompeleFranki Speleman

A1 Journal Article in GENOME MEDICINE

The miR-17-92 gene cluster is amplified and overexpressed in retinoblastoma

E BiewaldPieter MestdaghH StephanKatleen De PreterT ThorM BaumannD LohmannA EggertFranki SpelemanA Schramm et al.

The miR-17-92 gene cluster is amplified and overexpressed in retinoblastoma

J SchulteE BiewaldPieter MestdaghH StephanKatleen De PreterD LohmannFranki SpelemanA SchrammJo VandesompeleA Eggert

The prognostic significance of genomic profiles in cancer

Franki Speleman

Unusual 8p inverted duplication deletion with telomere capture from 8q

Karen BuysseF AntonacciBert CallewaertBart LoeysUlrike FränkelVictoria SiuGeert MortierFranki SpelemanBjörn Menten

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

Using real-time qPCR to evaluate RNAi-mediated gene silencing

Tom Van MaerkenPieter MestdaghS De ClercqFilip PattynNurten YigitAnne De PaepeJ C MarineFranki SpelemanJo Vandesompele

A2 Journal Article in BioTechniques Protocol Guide

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

I. BrayK. BryanS. PrenterP. G. BuckleyN. H. FoleyD. M. MurphyL. AlcockPieter MestdaghJo VandesompeleFranki Speleman et al.

A1 Journal Article in PLoS One

2008

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes

Karl VandepoeleVanessa AndriesNadine Van RoyKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki SpelemanFrans Van Roy

A1 Journal Article in PLOS ONE

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the the human NBPF1 and ACCN1 genes

Frans Van RoyKlaas VandepoeleNadine Van RoyVanessa AndriesKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki Speleman

Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas (vol 47, pg 197, 2008)

Prakash NairKatleen De PreterJo VandesompeleFranki SpelemanRaymond L Stallings

Aberrant splicing of the PTPRD gene mimics microdeletions identified-at locus this in neuroblastomas

Prakash NairKatleen De PreterJo VandesompeleFranki SpelemanRaymond L Stallings

A1 Journal Article in GENES CHROMOSOMES & CANCER

Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogenetique de hematologique

C GERVAISA MURATIC HELIASS STRUSKIA EISCHENE LIPPERTI TIGAUDD PENTHERC BASTARDF MUGNERET et al.

A1 Journal Article in LEUKEMIA

Array CGH: een nieuwe revolutionaire techniek in de detectie van chromosomale defecten bij kinderen met mentale retardatie en aangeboren afwijkingen

Björn MentenKaren BuysseGeert MortierFranki Speleman

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

Evi MichelsJasmien HoebeeckKatleen De PreterAlexander SchrammBénédicte BrichardAnne De PaepeAngelika EggertGenevieve LaureysJo VandesompeleFranki Speleman

A1 Journal Article in BMC CANCER

Copy number alterations and copy number variation in cancer: close encounters of the bad kind

Franki SpelemanCandy KumpsKaren BuysseBruce PoppeBjörn MentenKatleen De Preter

A1 Journal Article in CYTOGENETIC AND GENOME RESEARCH

Delineation of a critical region on chromosome 18 for the del(18)(q12.2q21.1) syndrome

Karen BuysseBjörn MentenAnn OostraSylvie TavernierGeert MortierFranki Speleman

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

EGFR and K-RAS gene status evaluation in anal canal squamous cell carcinoma

N Van DammeNadine Van RoyFranki SpelemanA BolsJo Van DorpeP PauwelsM Peeters

Evaluation of EGFR and K-RAS gene status in squamous cell carcinoma of the anal canal.

Nancy Van DammeNadine Van RoyFranki SpelemanA BOLSJ VAN DORPEPatrick PauwelsMarc Peeters

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22

An De WeerFranki SpelemanBarbara CauwelierNadine Van RoyNurten YigitBruno VerhasseltBarbara De MoerlooseYves BenoitLucien NoensDominik Selleslag et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)

An De WeerBruce PoppeBarbara CauwelierA CARLIERJ DIERICKBruno VerhasseltJan PhilippéNadine Van RoyFranki Speleman

A1 Journal Article in BMC CANCER

Expression profiling of a new class of non-coding RNAs in human neuroblastoma

Pieter MestdaghFilip PattynKatleen De PreterJoëlle VermeulenAnne De PaepeFranki SpelemanJo Vandesompele

Gene sets enrichment analysis of chromosomal regions

Katleen De PreterRoland BarriotFranki SpelemanJo VandesompeleYves Moreau

High resolution genome analysis for improved prognostic stratification and candidate gene selection in neuroblastoma

Evi MichelsFranki SpelemanJo Vandesompele

High throughput stem-loop RT-PCR miRNA expression profiling using minute amounts of input RNA reveals new insights in neuroblastoma pathogenesis

Pieter MestdaghJoëlle VermeulenKatleen De PreterFilip PattynGenevieve LaureysRosa NogueraMarta PiquerasFranki SpelemanJo Vandesompele

High-throughput stem-loop RT-PCR miRNA expression profiling using minute amounts of input RNA

Pieter MestdaghTom FeysNathalie BernardSimone GuentherCaifu ChenVladimir BenesFranki SpelemanJo Vandesompele

High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA

Pieter MestdaghTom FeysNathalie BernardSimone GuentherCaifu ChenFranki SpelemanJo Vandesompele

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH)

I LUQUETJL LAIC BARINL BARANGERC BILHOU-NABERAE LIPPERTC GERVAISP TALMANTP CORNILLET-LEFEBVREC PEROT et al.

A1 Journal Article in LEUKEMIA

Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics

Jo VandesompeleEvi MichelsKatleen De PreterBjörn MentenAlexander SchrammAngelika EggertPeter F AmbrosValérie CombaretNadine FrancotteFrancesca Antonacci et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Identification of ALK as a major familial neuroblastoma predisposition gene

YP MOSSEM LAUDENSLAGERL LONGOKA COLEA WOODEF ATTIYEHMJ LAQUAGLIAR SENNETTJE LYNCHP PERRI et al.

A1 Journal Article in NATURE

Investigation of the EGFR and K-RAS gene status in squamous cell carcinoma of the anal canal

Nancy Van DammeNadine Van RoyPieter DemetterFranki SpelemanA BolsJo Van DorpeN NagyJ Van LaethemPatrick PauwelsMarc Peeters

Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma

Katleen De PreterBjörn MentenSara De BrouwerCandy KumpsEvi MichelsNadine Van RoyJo VandesompeleFranki Speleman

A1 Journal Article in CANCER LETTERS

Mapping of 5q35 chromosomal rearrangements within a genomically unstable region

Karen BuysseA CREPELBjörn MentenFilip PattynF ANTONACCIJ VELTMANL LARSENZ TüMERA DE KLEINI VAN DE LAAR et al.

A1 Journal Article in Journal of Medical Genetics

MICRORNA PROFILING OF EVI1 DEREGULATED MYELOID LEUKEMIA

An De WeerBruce PoppePieter MestdaghPieter Van VlierbergheNadine Van RoyAnne De PaepeBruno VerhasseltJo VandesompeleFranki Speleman

MicroRNA signatures in genetic subtypes of T-cell acute lymphoblastic leukemia.

Pieter Van VlierbergheBruce PoppeNadine Van RoyTom TaghonJean PlumB CauwelierD SelleslagP HeimannP VandenbergheN Dastugue et al.

MYCN regulates oncogenic and tumour suppressor miRNA networks in neuroblastoma

Pieter MestdaghJoëlle VermeulenFilip PattynLiesbeth VercruysseAnne De PaepeGenevieve LaureysFranki SpelemanJo Vandesompele

Positional gene enrichment analysis of gene sets for high-resolution identification of overrepresented chromosomal regions

Katleen De PreterRoland BarriotFranki SpelemanJo VandesompeleYves Moreau

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Real-time qPCR as a tool for evaluating RNAi-mediated gene silencing

Tom Van MaerkenPieter MestdaghSarah De ClercqFilip PattynNurten YigitAnne De PaepeJean-Christophe MarineFranki SpelemanJo Vandesompele

A2 Journal Article in Bioradiations

Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes

HC MEFFORDAJ SHARPC BAKERA ITSARAZS JIANGKaren BuysseSW HUANGVK MALONEYJA CROLLAD BARALLE et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Unmasking of epigenetically silenced microRNAs in neuroblastoma

Jasmien HoebeeckGeert DeclerckPieter MestdaghFilip PattynKatleen De PreterJoëlle VermeulenNurten YigitAnne De PaepeFranki SpelemanJo Vandesompele

2007

A detailed inventory of DNA copy number alterations in four commonly used Hodgkin lymphoma cell lines

Tom FeysBruce PoppeKatleen De PreterNadine Van RoyBruno VerhasseltPascale De PaepeAnne De PaepeFranki Speleman

A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines

Tom FeysBruce PoppeKatleen De PreterNadine Van RoyBruno VerhasseltPascale De PaepeAnne De PaepeFranki Speleman

A1 Journal Article in HAEMATOLOGICA

Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies

Bruce PoppeAnne De PaepeFranki Speleman

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Array CGH analysis of subnanogram quantities of DNA using whole genome amplification: opportunities for detection of copy number alterations in Hodgkin's lymphoma

Tom FeysBart PoppeBruno VerhasseltPascale De PaepeBjörn MentenJo VandesompeleNadine Van RoyAnne De PaepeFranki Speleman

ArrayCGH based classification of neuroblastoma into genomic subgroups

Sara De BrouwerEvi MichelsJo VandesompeleKatleen De PreterJasmien HoebeeckJoëlle VermeulenAlexander SchrammJan J MolenaarBjörn MentenBarbara Marques et al.

ArrayCGH-based classification of neuroblastoma into genomic subgroups

Evi MichelsJo VandesompeleKatleen De PreterJasmien HoebeeckJoëlle VermeulenAlexander SchrammJan J MolenaarBjörn MentenBarbara MarquesRaymond L Stallings et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCR β-HOXA rearrangement : a study of the Groupe Francophone de Cytogénétique Hématologique

Barbara CauwelierH CavéC GervaisM LessardC BarinC PerotJ Van den AkkerF MugneretC CharrinMP Pagès et al.

A1 Journal Article in LEUKEMIA

De bijdrage van M-FISH aan de moleculaire diagnostiek in de hemato-oncologie

Bruce PoppeNadine Van RoyNurten YigitAnne De PaepeFranki Speleman

A2 Journal Article in Ned Tijdschr Hematol

Detection of DNA copy number alterations in cancer by array comparative genomic hybridization

Evi MichelsKatleen De PreterNadine Van RoyFranki Speleman

A1 Journal Article in GENETICS IN MEDICINE

Duplication and rearrangement of the MYB oncogene in T-cellacute lymphoblastic leukemia

I LAHORTIGABarbara CauwelierK DEKEERSMAECKERP VAN VLIEBERGHEC GRAUXF LAMBERTN MENTENSHB BEVERLOOR PIETERSFranki Speleman et al.

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya LahortigaKim De KeersmaeckerPieter Van VlierbergheCarlos GrauxBarbara CauwelierFrederic LambertNicole MentensH Berna BeverlooRob PietersFranki Speleman et al.

A1 Journal Article in NATURE GENETICS

Genome wide promoter methylation analysis in neuroblastoma with perspectives for integrated molecular profiling

Jasmien HoebeeckMaté OngenaertEvi MichelsKatleen De PreterJoëlle VermeulenNurten YigitAnne De PaepeWim Van CriekingeFranki SpelemanJo Vandesompele

Guidelines for molecular karyotyping in constitutional genetic diagnosis

JR VERMEESCHH FIEGLERN DE LEEUWK SZUHAIJ SCHOUMANSR CICCONEFranki SpelemanA RAUCHJ CLAYTON-SMITHC VAN RAVENSWAAIJ et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors

Jasmien HoebeeckEvi MichelsBjörn MentenNadine Van RoyAngelika EggertAlexander SchrammKatleen De PreterNurten YigitEls De SmetAnne De Paepe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Identification of EVI1 transcriptional target genes using RNAI

An De WeerBruce PoppeB CAUWEUERNadine Van RoyBruno VerhasseltFranki Speleman

Integration of molecular cytogenetics, array CGH and expression profiling in the study of neuroblastoma: implications for future therapy.

Franki Speleman

Integrative genomics in neuroblastoma research

Franki SpelemanKatleen De PreterEvi MichelsJasmien HoebeeckFilip PattynJoëlle VermeulenNadine Van RoyAnne De PaepeGenevieve LaureysJo Vandesompele

International consensus for neuroblastoma molecular diagnostics: report from the international neuroblastoma risk grouping (INRG) biology committee

PF AMBROSIM AMBROSGM BRODEURM HABERJ KHANA NAKAGAWARAG SCHLEIERMACHERFranki SpelemanR SPITZJM MARIS

Mapping biomedical concepts onto the human genome by mining literature on chromosomal aberrations

S VAN VOORENB THIENPONTBjörn MentenFranki SpelemanB DE MOORJ VERMEESCHY MOREAU

A1 Journal Article in NUCLEIC ACIDS RESEARCH

MicroRNA profiling of EVI1 deregulated myeloid leukemia

An De WeerBruce PoppePieter MestdaghNadine Van RoyAnne De PaepeBruno VerhasseltJo VandesompeleFranki Speleman

Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1

Ophélia MaertensSofie De SchepperJo VandesompeleHilde BremsIne HeynsSandra JanssensFranki SpelemanEric LegiusLudwine Messiaen

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

New insights into the genetic basis of neuroblastoma

Franki SpelemanKatleen De PreterJasmien HoebeeckNadine Van RoyJo Vandesompele

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14

Björn MentenKaren BuysseF ZAHIRJan HellemansSJ HAMILTONT COSTAC FAGERSTROMG ANADIOTISD KINGSBURYBC MCGILLIVRAY et al.

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Putting DNA arrays in the context of chromosomes: chromosomes are the context!

Franki Speleman

qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

Jan HellemansGeert MortierAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in GENOME BIOLOGY

RANBP17-TLX3: A hot spot region for both constitutional and acquired rearrangements

Karen BuysseBjörn MentenF ANTONACCIJA VELTMANLA LARSENZ TUMERGeert MortierFranki Speleman

Real-time PCR quality control for gene expression profiling on the LightCycler 480 System

Jasmien HoebeeckFilip PattynY NURTENE DE SMETFranki SpelemanJo Vandesompele

A3 Journal Article in Biochemica

Real-time quantitative PCR as an alternative to Southern blot or fluorescence in situ hybridization for detection of gene copy number changes.

Jasmien HoebeeckFranki SpelemanJo Vandesompele

Bookchapter in Methods in Molecular Biology

Report of 38 patients with hyperdiploid karyotype in acute myeloid leukemia: A groupe francais de cytogenetique hematologique study

C TERREI LUQUETJL LAIC BARINL BARANGERC BILHOU-NABERAE LIPPERTC GERVAISP TALMANTP CORNILLET-LEFEBVRE et al.

Report of a female patient with mental retardation and tall stature due to a chromosomal rearrangement disrupting the OPHN1 gene on Xq12

Björn MentenKaren BuysseStefan VermeulenVALERIE MEERSSCHAUTJo VandesompeleBL NGNP CARTERGeert MortierFranki Speleman

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

Report of an unusual translocation t(3;14)(q26;q32) involving both EVI1 and IGH in an unclassified acute myeloid leukaemia (AML)

V HAVELANGEG AMEYEA DEWEERK BAHLOULAC MULLIERJM LIBOUTONM DETRAITP SAUSSOYSBruce PoppeFranki Speleman et al.

Subtelomeric imbalances in phenotypically normal individuals

I BALIKOVABjörn MentenT DE RAVELC LE CAIGNECB THIENPONTM URBINAM DOCO-FENZYM DE RADEMAEKERGeert MortierF KOOY et al.

A1 Journal Article in HUMAN MUTATION

Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome

A SCHRAMMJo VandesompeleJH SCHULTES DREESMANNL KADERALIB BRORSR EILSFranki SpelemanA EGGERT

A1 Journal Article in CLINICAL CANCER RESEARCH

2006

Array CGH: een nieuwe revolutionaire techniek in de detectie van chromosomale defecten

Björn MentenKaren BuysseGeert MortierFranki Speleman

A4 Journal Article in DE AGENDA PEDIATRIE (BRUSSEL)

Comprehensive NF1 screening on cultured Schwann cells from neurofibromas: towards an extensive study of the somatic mutation spectrum in neurofibromatosis type 1

Ophélia MaertensHilde BremsJo VandesompeleThomas De RaedtIne HeynsThorsten RosenbaumSofie De SchepperAnne De PaepeGeert MortierSandra Janssens et al.

A1 Journal Article in Human Mutation

Culturing in vitro produced blastocysts in sequential media promotes ES cell derivation

Jun LiuLore SchoonjansSeverine TielensFranki SpelemanMaria CornelissenPetra De SutterMarc DhontJosiane Van der Elst

A1 Journal Article in MOLECULAR REPRODUCTION AND DEVELOPMENT

Emerging patterns of cryptic chromosomal imbalance in patients with idiopathic mental retardation and multiple congenital anomalies: a new series of 140 patients and review of published reports

Björn MentenN MAASB THIENPONTKaren BuysseJo VandesompeleC MELOTTET DE RAVELS VAN VOORENI BALIKOVAL BACKX et al.

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

EVII is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements

Bruce PoppeN DASTUGUEJo VandesompeleBarbara CauwelierB DE SMETNurten YigitAnne De PaepeJ CERVERAC RECHERV DE MAS et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model

I GANTOISJo VandesompeleFranki SpelemanE REYNIERSR D'HOOGELA SEVERIJNENR WILLEMSENF TASSONERF KOOY

A1 Journal Article in NEUROBIOLOGY OF DISEASE

GAB2 is a novel target of 11q amplification in AML/MDS

A ZATKOVAC SCHOCHFranki SpelemanBruce PoppeC MANNHALTERC FONATSCHK WIMMER

A1 Journal Article in GENES CHROMOSOMES & CANCER

Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints

Evi MichelsJo VandesompeleJasmien HoebeeckBjörn MentenKatleen De PreterGenevieve LaureysNadine Van RoyFranki Speleman

A1 Journal Article in CYTOGENETIC AND GENOME RESEARCH

High throughput analyses for assessment of DNA copy number and methylation status for chromosome 3p genes in high-risk neuroblastoma

Jasmien HoebeeckFranki SpelemanJo Vandesompele

HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation

J BergeronE ClappierB CauwelierN DastugueC MillienE DelabesseK BeldjordFranki SpelemanJ SoulierE Macintyre et al.

A1 Journal Article in LEUKEMIA

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes

Katleen De PreterJo VandesompelePierre HeimannNurten YigitSiv BeckmanAlexander SchrammAngelika EggertRaymond L StallingsYves BenoitMarleen Renard et al.

A1 Journal Article in GENOME BIOLOGY

Identification of MYCN transcriptional target genes in neuroblastoma

Filip PattynFranki SpelemanJo Vandesompele

Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements

R BergerM BussonL BarangerC HéliasM LessardN DastugueFranki Speleman

A1 Journal Article in LEUKEMIA

MethBLAST and methPrimerDB: web-tools for PCR based methylation analysis

Filip PattynJasmien HoebeeckPiet RobbrechtEvi MichelsAnne De PaepeG BOTTUD COORNAERTR HERZOGFranki SpelemanJo Vandesompele

A1 Journal Article in BMC BIOINFORMATICS

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCR beta locus rearrangements and putative new T-cell oncogenes

Barbara CauwelierN DASTUGUEJ COOLSBruce PoppeC HERENSAnne De PaepeA HAGEMEIJERFranki Speleman

A1 Journal Article in LEUKEMIA

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients

Ophélia MaertensH PRENENA WOZNIAKR SCIOTPatrick PauwelsI DE WEVERJR VERMEESCHT DE RAEDTAnne De PaepeFranki Speleman et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Real-time quantitative allele discrimination assay using 3 ' locked nucleic acid primers for detection of low-percentage mosaic mutations

Ophélia MaertensE LEGIUSFranki SpelemanL MESSIAENJo Vandesompele

Editorial material

Recurrent t(3;17) translocations in AML with EVII rearrangement.

A De WeerBruce PoppeB CauwelierNadine Van RoyN DastugueBarbara De MoerlooseYves BenoitLucien NoensAnne De PaepeFranki Speleman

Recurrent T(3;17)translocations in AML with EVI1 rearrangement

An De WeerBruce PoppeB CauwelierNadine Van RoyN DASTUGUEBarbara De MoerlooseYves BenoitLucien NoensAnne De PaepeFranki Speleman

RTPrimerDB : the real-time PCR primer and probe database, major update 2006

Filip PattynPiet RobbrechtAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Screening for EVII: ectopic expression absent in T-cell acute lymphoblastic leukemia patients and cell lines

An De WeerBruce PoppeB CauwelierNadine Van RoyN DASTUGUEA HAGEMEIJERAnne De PaepeFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma

Tom Van MaerkenFranki SpelemanJ VERMEULENIrina LambertzSarah De ClercqEls De SmetNurten YigitV COPPENSJan PhilippéAnne De Paepe et al.

A1 Journal Article in CANCER RESEARCH

Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients

T DE RAEDTOphélia MaertensM CHMARAH BREMSI HEYNSR SCIOTE MAJOUNIEM UPADHYAYASofie De SchepperFranki Speleman et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

The TCRB-HOXA rearrangement in T-ALL leads to a specific increase of the alternative HOXA10b transcript

B CauwelierH CAVÉN DASTUGUEP HEIMANNH ANTOINE-POIRELBruno VerhasseltYves BenoitBarbara De MoerlooseNadine Van RoyA HAGEMEIJER et al.

The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma

Jasmien HoebeeckJo VandesompeleHelén NissonKatleen De PreterNadine Van RoyEls De SmetNurten YigitAnne De PaepeGenevieve LaureysSven Påhlman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1

Nadine Van RoyJo VandesompeleBjörn MentenH NILSSONEls De SmetM ROCCHIAnne De PaepeS PAHLMANFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

2005

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

Franki SpelemanBarbara CauwelierN DASTUGUEJ COOLSBruno VerhasseltBruce PoppeNadine Van RoyJo VandesompeleC GRAUXA UYTTEBROECK et al.

A1 Journal Article in LEUKEMIA

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution

Karl VandepoeleNadine Van RoyKatrien StaesFranki SpelemanFrans Van Roy

A1 Journal Article in MOLECULAR BIOLOGY AND EVOLUTION

Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies

Bruce PoppeFranki SpelemanAnne De Paepe

An interstitial deletion of chromosome 7 at band q21: A case report and review

Winnie CourtensStefan VermeulenWim WuytsLudwine MessiaenJan WautersLieve NuytinckNils PeetersKatrien StormFranki SpelemanMarkus Nothen

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays

Björn MentenFilip PattynKatleen De PreterPiet RobbrechtEvi MichelsKaren BuysseGeert MortierAnne De PaepeSteven van VoorenJoris Vermeesch et al.

A1 Journal Article in BMC BIOINFORMATICS

Familial pericentric inversion of chromosome 18: behavioral abnormalities in patients heterozygous for either the dup(18p)/del(18q) or dup(18q)/del(18p) recombinant chromosome

Stefan VermeulenFranki SpelemanL VANRANSBEECKJasmine VerspeetBjörn MentenMR VERSCHRAEGEN-SPAEPhilippe De WildeLudwine MessiaenRC MICHAELISJuliaan Leroy

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

HOYA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS

Bruce PoppeNurten YigitBarbara De MoerlooseAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Identification of an unbalanced X-autosome translocation by array CGH in a boy with a syndromic form of chondrodysplasia punctata brachytelephalangic type

Björn MentenKaren BuysseJo VandesompeleEls De SmetAnne De PaepeFranki SpelemanGeert Mortier

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

Impact of RNA quality on reference gene expression stability

Claudina Perez NovoCindy ClaeysFranki SpelemanPaul Van CauwenbergeClaus BachertJo Vandesompele

A1 Journal Article in BIOTECHNIQUES

Molecular karyotyping: Array CGH quality criteria for constitutional genetic diagnosis

JR VERMEESCHC MELOTTEG FROYENS VAN VOORENB DUTTAN MAASS VERMEULENBjörn MentenFranki SpelemanB DE MOOR et al.

A1 Journal Article in JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

No evidence for correlation of DDX1 gene amplification with improved survival probability in patients with MYCN-amplified neuroblastomas

Katleen De PreterFranki SpelemanValérie CombaretJohn LunecJulien BoardAndy PearsonAnne De PaepeNadine Van RoyGenevieve LaureysJo Vandesompele

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization

Bruce PoppeBarbara CauwelierH VAN LIMBERGENNurten YigitJan PhilippéBruno VerhasseltAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements

Bruce PoppeP DE PAEPEL MICHAUXN DASTUGUEC BASTARDC HERENSELS MOREAUF CAVAZZININurten YigitH VAN LIMBERGEN et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11

Katleen De PreterJo VandesompeleBjörn MentenPhilippa CarrHeike FieglerAnders EdsjöNigel P CarterNurten YigitWim WaelputNadine Van Roy et al.

A1 Journal Article in BMC GENOMICS

Rapid detection of VHL exon deletions using real-time quantitative PCR

Jasmien HoebeeckR VAN DER LUIJTBruce PoppeEls De SmetNurten YigitKathleen ClaesR ZEWALDGJ DE JONGAnne De PaepeFranki Speleman et al.

A1 Journal Article in LABORATORY INVESTIGATION

Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma

Jo VandesompeleM BAUDISKatleen De PreterNadine Van RoyP AMBROSN BOWNC BRINKSCHMIDTH CHRISTIANSENV COMBARETM LASTOWSKA et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

2004

Claes Lundsteen - in memoriam

J GRAHAME BLENNOWMG BOAVIDAN CARTERC CREMERT CREMERO DELATTRET GERDESE GRANUMA HAGEMEIJER et al.

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951

H CAVÉS SUCIUC PREUDHOMMEBruce PoppeA ROBERTA UYTTEBROECKM MALETP BOUTARDYves BenoitL MAUVIEUX et al.

A1 Journal Article in BLOOD

Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

Katleen De PreterFilip PattynGeert BerxKristin StrumaneBjörn MentenFrans Van RoyAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in BMC GENOMICS

DUP25 remains unconfirmed

Stefan VermeulenBjörn MentenSylvia De BiePaul CouckeFransiska MalfaitJulie De BackerFranki SpelemanAnne De PaepeB LOEYS

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

Bruce PoppeJo VandesompeleC SCHOCHC LINDVALLK MROZEKCD BLOOMFIELDHB BEVERLOOL MICHAUXN DASTUGUEC HERENS et al.

A1 Journal Article in BLOOD

Gene-expression profiling reveals distinct expression patterns for classic versus variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma

M VAN GELEGM BOYLEAL COOKJo VandesompeleTom BoonefaesPieter RottiersNadine Van RoyAnne De PaepePG PARSONSJH LEONARD et al.

A1 Journal Article in ONCOGENE

Genetic study of high-stage neuroblastomas ans normal neuroblastoma progenitors

Katleen De PreterFranki SpelemanAnne De Paepe

Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis

Jan HellemansO PREOBRAZHENSKAAndy WillaertP DEBEERPETER VERDONKT COSTAK JANSSENSBjörn MentenNadine Van RoyStefan Vermeulen et al.

A1 Journal Article in NATURE GENETICS

Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines

D MATHYSENNadine Van RoyW VAN HULGenevieve LaureysP AMBROSFranki SpelemanW WUYTS

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Molecular cytogenetic analysis of complex chromosomal rearrangements in patients with mental retardation and congenital malformations: delineation of 7q21.11 breakpoints

Stefan VermeulenBjörn MentenNadine Van RoyHeidi Van LimbergenAnne De PaepeGeert MortierFranki Speleman

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation

A EDSJOH NILSSONJo VandesompeleJ KARLSSONFilip PattynLA CULPFranki SpelemanS PAHLMAN

A1 Journal Article in LABORATORY INVESTIGATION

No evidence for involvement of SDHD in neuroblastoma pathogenesis

Katleen De PreterJo VandesompeleJasmien HoebeeckCaroline VandenbroeckeJoél SmetAnnick NuytsGenevieve LaureysValérie CombaretNadine Van RoyFrank Roels et al.

A1 Journal Article in BMC CANCER

Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma (vol 101, pg 103, 2002)

JH LEONARDAL COOKMireille Van GeleGM BOYLEKJ INGLISFranki SpelemanRA STURM

Recommendations for the cytogenetic management of acute myeloblastic leukemia (AML) proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

C BASTARDL BARANGERC BILHOU-NABERAC CHARRINN DASTUGUEV ECLACHEM LAFAGE-POCHITALOFFJL LAID LEROUXM LESSARD et al.

A1 Journal Article in PATHOLOGIE BIOLOGIE

Recommendations for the cytogenetic management of adult and chidhoodacute lymphoblastic leukemia (ALL) proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

L BARANGERC BARIC CHARRINP CORNILLET-LEFEBVREN DASTUGUEM LAFAGE-POCHITALOFFC PEROTBruce PoppeS ROMANAFranki Speleman et al.

A1 Journal Article in PATHOLOGIE BIOLOGIE

Recommendations for the cytogenetic management of myelodysplastic syndromes proposed by the Groupe Francais de Cytogenetique Hematologique (GFCH)

C BASTARDI LUCQUETMJ MOZZICONACCIBruce PoppeS RAYNAUDFranki Speleman

A1 Journal Article in PATHOLOGIE BIOLOGIE

Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features

M STEVENS-KROEFBruce PoppeS VAN ZELDEREN-BHOLAE VAN DEN BERGM VAN DER BLIJ-PHILIPSENAG VAN KESSELR SLATERG HAMERSL MICHAUXFranki Speleman et al.

A1 Journal Article in LEUKEMIA

ZFHX3 (zinc finger homeobox 3)

Nadine Van RoyFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

2003

3q rearrangements in myeloid malignancies

Bruce PoppeNicole DastugueFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma

P DE PAEPEM BAENSH VAN KRIEKENBruno VerhasseltM STULANN SIMONSBruce PoppeGenevieve LaureysP BRONSPieter Vandenberghe et al.

A1 Journal Article in BLOOD

Application of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells

Katleen De PreterJo VandesompelePierre HeimannMark M KockxMireille Van GeleJasmien HoebeeckEls De SmetMartine DemarcheGenevieve LaureysNadine Van Roy et al.

A1 Journal Article in CANCER LETTERS

Evidence for involvement of a tumor suppressor gene on 1p in malignant peripheral nerve sheath tumors

Nadine Van RoyM VAN GELEJo VandesompeleLudwine MessiaenSimon Van BelleR SCIOTK MORTELEJ GYSELINCKE MICHIELSRamses Forsyth et al.

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Expression of developmentally regulated transcription factors in Merkel cell carcinoma

JH LEONARDAL COOKM VAN GELEFranki SpelemanRA STURM

Expression profiling reveals involvement of the GABA(A) receptor subunit delta in the fragile X syndrome

I GANTOISJo VandesompeleFranki SpelemanR D'HOOGEL SEVERIJNENR WILLEMSENF TASSONER KOOY

Gene expression profiling reveals two distinct subtypes of Merkel cell carcinoma

M VAN GELEG BOYLEAL COOKTom BoonefaesPieter RottiersNadine Van RoyAnne De PaepeP PARSONSJH LEONARDFranki Speleman

Gene expression profiling reveals two distinct subtypes of Merkel cell carcinoma. The Merkel cell

M VAN GELEG BOYLEA COOKTom BoonefaesP ROTTIERSNadine Van RoyAnne De PaepeP PARSONSJ LEONARDFranki Speleman

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

Jo VandesompeleAnders EdsjöKatleen De PreterHåkan AxelsonFranki SpelemanSven Påhlman

A1 Journal Article in ONCOGENE

Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

C DODEJ LEVILLIERSJM DUPONTAnne De PaepeN LE DUN SOUSSI-YANICOSTASRS COIMBRAS DELMAGHANIS COMPAIN-NOUAILLEF BAVEREL et al.

A1 Journal Article in NATURE GENETICS

Quality assessment of genetic markers used for therapy stratification

IM AMBROSJ BENARDM BOAVIDAN BOWNH CARONV COMBARETJ COUTURIERC DARNFORSO DELATTREJ FREEMAN-EDWARD et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA

Claudina Perez NovoJo VandesompeleGabriële HoltappelsFranki SpelemanPhilippe GevaertPaul Van CauwenbergeClaus Bachert

A1 Journal Article in BMC BIOTECHNOLOGY

Regulation of peroxisomal genes by DHEA and vitamin D

M DEPRETERJo VandesompeleS FERDINANDUSSEFranki SpelemanFrank Roels

A1 Journal Article in PEROXISOMAL DISORDERS AND REGULATION OF GENES

RTPrimerDB : the Real-Time PCR primer and probe database

Filip PattynFranki SpelemanAnne De PaepeJo Vandesompele

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Soft tissue tumors : clear cell sarcoma

Bruce PoppeRamses ForsythKarl DhaeneFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH)

R BERGERN DASTUGUEM BUSSONJ VAN DEN AKKERC PEROTP BALLERINIA HAGEMEIJERL MICHAUXC CHARRINMP PAGES et al.

A1 Journal Article in LEUKEMIA

t(9;14)(p13;q32)

Bruce PoppePascale De PaepeFranki Speleman

A2 Journal Article in ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY

2002

A brief commentary on "Chromosomal aberrations in neuroblastoma cell lines identified by cross species color banding and chromosome painting".

Jo VandesompeleFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Jo VandesompeleKatleen De PreterFilip PattynBruce PoppeNadine Van RoyAnne De PaepeFranki Speleman

A1 Journal Article in GENOME BIOLOGY

Combined karyotyping, CGH and M-fish analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.

Mireille Van GeleJH LEONARDNadine Van RoyHeidi Van LimbergenSimon Van BelleVeronique CocquytH SALWENAnne De PaepeFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real time RT-PCR.

Jo VandesompeleAnne De PaepeFranki Speleman

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

HOX11L2 expression linked to t(5;14)(q35;q32) is not associated with poor prognosis in childhood T-ALL treated in EORTC trials 58 881 and 58 951

H CAVÉS SUCIUC PREUDHOMMEBruce PoppeA ROBERTA UYTTEBROEKM MALETP BOUTARDYves BenoitL MAUVIEUX et al.

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.

Heidi Van LimbergenBruce PoppeL MICHAUXC HERENSJ BROWNLucien NoensZ BERNEMANR DE BOCKAnne De PaepeFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Kallmann syndrome in a patient with congenital spherocytosis and an interstitial 8p11.2 deletion.

Stefan VermeulenLudwine MessiaenP SCHEIRSylvia De BieFranki SpelemanAnne De Paepe

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type I patients.

Nadine Van RoyJo VandesompeleGeert BerxK STAESMireille Van GeleEls De SmetAnne De PaepeGenevieve LaureysP VAN DER DRIFTR VERSTEEG et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Meerkleuren fluorescentie in situ hybridisatie: methodologie en toepassingen in diagnostiek en onderzoek

Heidi Van LimbergenBruce PoppeStefan VermeulenNadine Van RoyAnne De PaepeFranki Speleman

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D : therapeutic implications

Marianne DepreterJo VandesompeleMarc EspeelFranki SpelemanFrank Roels

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia.

Heidi Van LimbergenBruce PoppeA JANSSENSR DE BOCKAnne De PaepeL NOENSFranki Speleman

A1 Journal Article in LEUKEMIA

Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.

JH LEONARDAL COOKMireille Van GeleGM BOYLEKJ INGLISFranki SpelemanRA STURM

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay.

Katleen De PreterFranki SpelemanV COMBARETJ LUNECGenevieve LaureysB EUSSENN FRANCOTTEJ BOARDA PEARSONAnne De Paepe et al.

A1 Journal Article in MODERN PATHOLOGY

2001

Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.

Bruce PoppeHeidi Van LimbergenNadine Van RoyE VANDECRUYSAnne De PaepeYves BenoitFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeH SALWENGenevieve LaureysN MANOELAnne De PaepeFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11Q deletion in tumors lacking MYCN amplification.

D PLANTAZJo VandesompeleNadine Van RoyM LASTOWSKAN BOWNV COMBARETMC FAVROTO DELATTREJ MICHONJ BENARD et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Deletion of chromosome 11q is the most frequent deletion detected by CGH in metastatic neuroblastoma lacking MYCN amplification

D PLANTAZJ VANDESOMPELENadine Van RoyN BROWNJ NICHOLSONM LASTOWSKAA PEARSONC BRINKSCHMIDTH CHRISTIANSENF LAMPERT et al.

A2 Journal Article in Int. J. of Cancer

Detailed characterization of 12 supernumerary ring chromosomes using micro-FISH and search for uniparental disomy.

BM ANDERLIDS SAHLENJ SCHOUMANSE HOLMBERGI AHSGRENGeert MortierFranki SpelemanE BLENNOW

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma

Mireille Van GeleJ Helen LeonardNadine Van RoyAnthony L CookAnne De PaepeFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Molecular characterization of a t(2;3)(p23;q26): A recurrent translocation involving the EVI1 gene

Bruce PoppeNurten YigitP MARYNENA HAGEMEIJERH VAN LIMBERGENB DE SMETAnne De PaepeFranki Speleman

Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.

Heidi Van LimbergenHB BEVERLOOE VAN DRUNENAnn JanssensK HAHLENBruce PoppeNadine Van RoyP MARYNENAnne De PaepeR SLATER et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma.

M LASTOWSKANadine Van RoyN BOWNFranki SpelemanP ROBERTSJ LUNECT STRACHANADJ PEARSONMS JACKSON

A1 Journal Article in MEDICAL AND PEDIATRIC ONCOLOGY

Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there?

Jo VandesompeleFranki SpelemanNadine Van RoyGenevieve LaureysC BRINKSCHMIDTH CHRISTIANSENF LAMPERTM LASTOWSKAN BOWNA PEARSON et al.

A1 Journal Article in MEDICAL AND PEDIATRIC ONCOLOGY

Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.

G STEELE-PERKINSW FANGXH YANGMireille Van GeleT CARLINGJ GUIM BUYSEJA FLETCHERJS LIUR BRONSON et al.

A1 Journal Article in GENES & DEVELOPMENT

2000

An integrated 5-Mb physical, genetic, and radiation hybrid map of a 1p36.1 region implicated in neuroblastoma pathogenesis.

N SPIEKERM BEITSMAP VAN SLUISI ROOBEEKJT DEN DUNNENFranki SpelemanH CARONR VERSTEEG

A1 Journal Article in GENES CHROMOSOMES & CANCER

Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.

Nadine Van RoyHeidi Van LimbergenJo VandesompeleMireille Van GeleBruce PoppeGenevieve LaureysAnne De PaepeFranki Speleman

A1 Journal Article in MEDICAL AND PEDIATRIC ONCOLOGY

Deletion mapping on the short arm of chromosome 1 in Merkel cell carcinoma.

JH LEONARDAL COOKD NANCARROWN HAYWARDM VAN GELENadine Van RoyFranki Speleman

A1 Journal Article in CANCER DETECTION AND PREVENTION

Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects.

Ludwine MessiaenT CALLENSGeert MortierDIANE BEYSENIna VandenbrouckeNadine Van RoyFranki SpelemanAnne De Paepe

A1 Journal Article in HUMAN MUTATION

Genetica en kanker: perspectieven voor diagnose en behandeling.

Franki SpelemanBruce Poppe

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Mutation analysis of P73 and TP53 in Merkel cell carcinoma.

Mireille Van GeleM KAGHADJH LEONARDNadine Van RoyJean NaeyaertMarie GeertsSimon Van BelleVeronique CocquytJ BRIDGER SCIOT et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.

H JUDSONNadine Van RoyL STRAINJo VandesompeleMireille Van GeleFranki SpelemanDT BONTHRON

A1 Journal Article in HUMAN GENETICS

Subtelomeric familial translocation t(2;7)(q37;q35) leading to partial trisomy 7q35 -> qter: Molecular cytogenetic analysis and clinical phenotype in two generations.

Franki SpelemanB CALLENSKarl LoggheNadine Van RoyA JAUCHMR VERSCHRAEGEN-SPAEJG LEROY

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

1999

99mTc-MIBI imaging in paediatric neuroblastoma and ganglioneuroma and its relation to P-glycoprotein

B DE MOERLOOSEC VAN DE WIELECatharina DhoogeJ PHILIPPEFranki SpelemanYves BenoitGenevieve LaureysRudi Dierckx

A single step real-time quantitative RT-PCR reaction for detection of the BCR/ABL fusion product

H VAN LIMBERENL VAN DE LOCHTBruce PoppeAnne De PaepeFritz OffnerE MENSINKFranki Speleman

Chromosome 7 short arm deletions and disease progression in CML

Bruce PoppeH VAN LIMBERGENANN JANSSENSNadine Van RoyBarbara De MoerlooseJ PHILLIPEAnne De PaepeFritz OffnerFranki Speleman

Closing in an the BPES gene on 3q23: Mapping of a de nova reciprocal translocation t(3;4)(q23;p15.2) breakpoint within a 45-kb cosmid and mapping of three candidate genes, RBP1, RBP2, and beta '-COP, distal to the breakpoint

Elfride De BaereNadine Van RoyFranki SpelemanY FUKUSHIMAAnne De PaepeLudwine Messiaen

A1 Journal Article in GENOMICS

Cytogenetic findings in bloom syndrome patients with myeloid malignancies

Bruce PoppeYves BenoitH VAN LIMBERGENNadine Van RoyEls VandecruysA JAUCHAnne De PaepeJ GERMANFranki Speleman

Delineation of two distinct 6p deletion syndromes.

AF DAVIESG MIRZAG SEKHONP TURNPENNYF LEROYFranki SpelemanC LAWN VAN REGEMORTERE VAMOSF FLINTER et al.

A1 Journal Article in HUMAN GENETICS

Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.

N BOWNS COTTERILLM LASTOWSKAS O'NEILLADJ PEARSOND PLANTAZM MEDDEBG DANGLOTC BRINKSCHMIDTH CHRISTIANSEN et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

hMSH6 deficiency and inactivation of the alpha E-catenin invasion-suppressor gene in HCT-8 colon cancer cells.

SJ VERMEULENPhilip DebruyneG MARRAFranki SpelemanP BOUKAMPJ JIRICNYAP CUTHBERTRF NEWBOLDFriedel NolletFrans Van Roy et al.

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

Identification of a novel CBFB/MYH11 fusion in a patient with AML-M1 and a t(16;16)(p13;q22)

H VAN LIMBERGENB VAN DER REIJDENBruce PoppeFritz OffnerNadine Van RoyH DAUWERSEAnne De PaepeFranki Speleman

Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the black and colored populations of South Africa.

L DU PLESSISE DIETZSCHMireille Van GeleNadine Van RoyP VAN HELDENMI PARKERDK MUGWANYAM DE GROOTMP MARXMJ KOTZE et al.

A1 Journal Article in CANCER RESEARCH

Neuroblastoma: from molecular cytogenetics to gene expression profiling

Jo VandesompeleNadine Van RoyGeert BerxD PLANTAZAnne De PaepeGenevieve LaureysFrans Van RoyFranki Speleman

Refined physical mapping and genomic structure of the EXTL1 gene.

W WUYTSN SPIEKERNadine Van RoyK DE BOULLEAnne De PaepePJ WILLEMSW VAN HULR VERSTEEGFranki Speleman

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Technetium-99m sestamibi imaging in paediatric neuroblastoma and ganglioneuroma and its relation to P-glycoprotein.

Barbara De MoerlooseC VAN DE WIELECatharina DhoogeJan PhilippéFranki SpelemanYves BenoitGenevieve LaureysRudi Dierckx

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE

The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells

Stefan VermeulenFriedel NolletE TEUGELSKM VENNEKENSFransiska MalfaitJan PhilippéFranki SpelemanMarc BrackeFrans Van RoyMarcus Mareel

A1 Journal Article in ONCOGENE

Unusual chromosome 16 rearrangement with absence of classical CBFB/MYH11 fusion transcripts

H VAN LIMBERGENBA VAN DER REIJDENBruce PoppeNadine Van RoyH DAUWERSEAnne De PaepeFranki Speleman

1998

A de novo interstitial deletion of the long arm of chromosome 7: a case report

W CourtensL MessiaenLieve NuytinckFranki SpelemanE Vamos

Assignment of SHOX2 (alias OG12X and SHOT) to human chromosome bands 3q25 -> q26.1 by in situ hybridization.

Elfride De BaereFranki SpelemanNadine Van RoyAnne De PaepeLudwine Messiaen

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta ' subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization

Elfride De BaereFranki SpelemanNadine Van RoyAnne De PaepeLudwine Messiaen

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization

Elfride De BaereFranki SpelemanNadine Van RoyK MORTIERAnne De PaepeLudwine Messiaen

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization

Mireille Van GeleFranki SpelemanJo VandesompeleNadine Van RoyJH Leonard

A1 Journal Article in CANCER RESEARCH

Cytogenetic and molecular analysis of cellular atypical mesoblastic nephroma.

Franki SpelemanE VAN DEN BERGCatharina DhoogeW OOSTERHUISB REDEKERChristian De PotterRYJ TAMMINGANadine Van RoyM MANNENS

A1 Journal Article in GENES CHROMOSOMES & CANCER

Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?

Stefan J VermeulenTR ChenFranki SpelemanFriedel NolletFrans Van RoyMarcus Mareel

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Extended sperm DNA fibres applied to high resolution physical gene mapping

T DineenFranki SpelemanNadine Van RoyA NolanJA Houghton

A2 Journal Article in ADVANCES IN REPRODUCTION

FISH identifies inv(16)(p13q22) masked by translocations in three cases of acute myeloid leukemia.

J DIERLAMMM STULH VRANCKXL MICHAUXDEMO WEGHUISFranki SpelemanD SELLESLAGMartin KramerLucien NoensJJ CASSIMAN et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization.

Jo VandesompeleNadine Van RoyMireille Van GeleGenevieve LaureysP AMBROSP HEIMANNC DEVALCKE SCHUURINGP BROCKJ OTTEN et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family.

W VAN HULW WUYTSJ HENDRICKXFranki SpelemanJ WAUTERSK DE BOULLENadine Van RoyP BOSSUYTPJ WILLEMS

A1 Journal Article in GENOMICS

Isolated Norrie disease in a female caused by a balanced translocation t(X,6).

Françoise MeireBart LafautFranki SpelemanMichel Hanssens

A2 Journal Article in OPHTHALMIC GENETICS

Molecular analysis of lp36 breakpoints in two Merkel cell carcinomas.

Mireille Van GeleNadine Van RoySG RONANLudwine MessiaenJo VandesompeleMarie GeertsM NAEYAERTE BLENNOWI BAR-AMTK DAS GUPTA et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular cytogenetic delineation of 17q translocation breakpoints in neuroblastoma cell lines.

M LASTOWSKANadine Van RoyN BROWNFranki SpelemanJ LUNECT STRACHANADJ PEARSONMS JACKSON

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular diagnostic evaluation of NF1 patients using the combined approach of karyotyping, fluorescent in situ hybridisation, the protein truncation assay and heteroduplex analysis

Ludwine MessiaenGeert MortierT CallensNadine Van RoyFranki SpelemanAnne De Paepe

Noonan-like phenotype in monozygotic twins with a duplication-deficiency of the long arm of chromosome 18 resulting from a maternal paracentric inversion.

W COURTENSD GROSSMANNadine Van RoyLudwine MessiaenE VAMOSV TOPPETD HAUMONTC STREYDIOA JAUCHJR VERMEESCH et al.

A1 Journal Article in HUMAN GENETICS

Ossified retroperitoneal malignant Schwannoma with spinal leptomeningeal metastases.

K MorteléMarc LemmerlingLuc DefreyneFranki SpelemanChristian De PotterSimon Van BelleMarc Kunnen

A1 Journal Article in NEURORADIOLOGY

1997

A constitutional balanced 1;17 neuroblastoma translocation

P VAN DER DRIFTA CHANGenevieve LaureysNadine Van RoyA WESTERVELDFranki SpelemanR VERSTEEG

Amplification units and translocation at chromosome 17q and c-erbB-2 overexpression in the pathogenesis of breast cancer.

Elisabeth CoeneVera SchelfhoutRA WINKLERAM SCHELFHOUTNadine Van RoyM GROOTECLAESFranki SpelemanCR DEPOTTER

A1 Journal Article in VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY

Analysis of 1;17 translocation breakpoints in neuroblastoma: Implications for mapping of neuroblastoma genes.

Nadine Van RoyGenevieve LaureysMireille Van GeleG OPDENAKKERR MIURAP VAN DER DRIFTA CHANR VERSTEEGFranki Speleman

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Comparative genomic hybridization analysis of human neuroblastomas: Detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.

Nadine Van RoyA JAUCHM VANGELEGenevieve LaureysR VERSTEEGA DEPAEPET CREMERFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Identification and characterization of a novel member of the EXT gene family, EXTL2.

W WUYTSW VAN HULJ HENDRICKXFranki SpelemanJ WAUTERSK DE BOULLENadine Van RoyT VAN AGTMAELP BOSSUYTPJ WILLEMS

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Interstitial deletion 2q33.3-q34 in a boy with a phenotype resembling the Seckel syndrome.

W COURTENSFranki SpelemanLudwine MessiaenJ BORMANSNadine Van RoyE VAMOS

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Interstitial telomeric sequences at the junction site of a jumping translocation

Joris Robert VermeeschPaul PetitFranki SpelemanKoen DevriendtJean-Pierre FrynsPeter Marynen

A1 Journal Article in HUMAN GENETICS

Malignant melanoma of the soft parts (clear-cell sarcoma): Confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocation.

Franki SpelemanO DELATTREM PETERE HAUBENNadine Van RoyE VANMARCK

A1 Journal Article in MODERN PATHOLOGY

Monosomy 22 in a mixed germ cell sex cord stromal tumor of the ovary

Franki SpelemanBart DermautChristian R De PotterMireille Van GeleNadine Van RoyAnne De PaepeGenevieve Laureys

A1 Journal Article in GENES CHROMOSOMES & CANCER

Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.

SJ VERMEULENF NOLLETE TEUGELSJan PhilippéFranki SpelemanFrans Van Roymarc brackeMarcus Mareel

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Sensitive and reliable detection of genomic imbalances in human neuroblastomas using comparative genomic hybridisation analysis.

Mireille Van GeleNadine Van RoyA JAUCHGenevieve LaureysYves BenoitVera SchelfhoutChristian De PotterP BROCKA UYTTEBROECKR SCIOT et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

1996

A human modifier of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1.

NC CHENGAJK CHANMM BEITSMAFranki SpelemanA WESTERVELDR VERSTEEG

A1 Journal Article in HUMAN MOLECULAR GENETICS

A putative tumor suppressor gene involved in Merkel cell carcinoma maps between p58 and D172

Franki SpelemanML GeertsFilomeen HaerynckBart DermautNadine Van Roy

Acute lymphoblastic leukemia as part of the retinoblastoma inherited cancer syndrome

J VAN DROOGENBROECKLucien NoensA JANSSENSFritz OffnerWerner Van HoveFranki Speleman

A2 Journal Article in Belg. Hematol. Soc, pp. 90

Chromosomal region 1p35-36 encodes for several neuroblastoma suppressor loci

R VERSTEEGH CARONP VANDERDRIFTFranki SpelemanGenevieve LaureysNadine Van RoyNC CHENG

Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21->q11.22 and two pseudogenes to 5p13 and 5q13.

Franki SpelemanR VERVOORTNadine Van RoyI LIEBAERSWS SLYW LISSENS

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Mosaic tetrasomy 15q25->qter in a newborn infant with multiple anomalies.

A VANDENENDENMR VERSCHRAEGEN-SPAENadine Van RoyW DECALUWEC DEPRAETERFranki Speleman

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Multiple polysomies in nasal polyps in children.

Franki SpelemanC DEPOTTERNadine Van RoyGenevieve Laureys

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization.

Franki SpelemanG VANCAMPNadine Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Refined genetic and physical mapping of BPES type II

Ludwine MessiaenBart LeroySylvia De BieK De PauwNadine Van RoyFranki SpelemanG Van CampAnne De Paepe

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

1995

1P36 : every subband a suppressor

R VersteegH CaronNC ChengP VanderdriftR SlaterA WesterveldPA VouteO DelattreGenevieve LaureysNadine Van Roy et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Assignment of the human beta-catenin gene (CTNNB1) to 3p22->p21.3 by fluorescence in situ hybridization.

J VANHENGELF NOLLETGeert BerxNadine Van RoyFranki SpelemanFrans Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Balanced translocation in a neuroblastoma patient disrupts a cluster of small nuclear RNA UI and tRNA genes in chromosomal band Ip36

Pauline van der DriftAlvin ChanGenevieve LaureysNadine Van RoyGrace SickmannJohan den DunnenAndries WesterveldFranki SpelemanRogier Versteeg

A1 Journal Article in GENES CHROMOSOMES & CANCER

Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES): clinical subtypes and their genotype

Bart LeroyLudwine MessiaenNadine Van RoyFranki SpelemanAnne De Paepe

Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES): report of a large family

Bart LeroyH VermeerschFranki SpelemanNadine Van RoyL MessiaenAnne De Paepe

Characterization of the chromosome breakpoints in a patient with a constitutional translocation T(1-17)(P36.31-P36.13-Q11.2-Q12) and neuroblastoma.

Genevieve LaureysR VERSTEEGFranki SpelemanP VANDERDRIFTU FRANCKEG OPDENAKKERNadine Van Roy

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

CONSTITUTIONAL TRANSLOCATION T(1-17)(P36.31-P36.13-Q11.2Q12.1) IN A NEUROBLASTOMA PATIENT. ESTABLISHMENT OF SOMATIC-CELL HYBRIDS AND IDENTIFICATION OF PND/A12M2 ON CHROMOSOME-1 AND NF1/SCYA7 ON CHROMOSOME-17 AS BREAKPOINT FLANKING SINGLE-COPY MARKERS.

Genevieve LaureysFranki SpelemanR VERSTEEGP VANDERDRIFTA CHANJuliaan LeroyU FRANCKEG OPDENAKKERNadine Van Roy

A1 Journal Article in ONCOGENE

Deletion mapping in neuroblastoma cell-lines suggests 2 distinct tumor-suppressor genes in the lp35-36 region, only one of which is associated with N-myc amplification.

NC CHENGNadine Van RoyA CHANM BEITSMAA WESTERVELDFranki SpelemanR VERSTEEG

A1 Journal Article in ONCOGENE

Evidence for 2 tumour-suppressor loci on chromosomal bands-lp35-36 involved in neuroblastoma - one probably imprinted, another associated with N-myc amplification.

H CARONM PETERP VANSLUISFranki SpelemanJ DEKRAKERGenevieve LaureysJ MICHONL BRUGIERESPA VOUTEA WESTERVELD et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Full triploidy in a liveborn preterm infant.

K SMETSFranki SpelemanPiet VanhaesebrouckNadine Van RoyJo Dehoorne

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Identification of 2 distinct chromosome-12-derived amplification units in neuroblastoma cell-line NGP.

Nadine Van RoyA FORUSO MYKLEBOSTNC CHENGR VERSTEEGFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Micronucleus induction in peripheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease.

Hubert ThierensAnne VralMarc Van EijkerenFranki SpelemanLeo De Ridder

A1 Journal Article in INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Molecular cytogenetic analysis of 1-17 translocations in neuroblastoma

Nadine Van RoyNC CHENGGenevieve LaureysG OPDENAKKERR VERSTEEGFranki Speleman

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

THE GENE FOR HUMAN GAP JUNCTION PROTEIN CONNEXIN37 (GJA4) MAPS TO CHROMOSOME 1P35.1, IN THE VICINITY OF D1S195.

G VANCAMPPaul CouckeFranki SpelemanNadine Van RoyEC BEYERBA OOSTRAPJ WILLEMS

A1 Journal Article in GENOMICS

1994

6 CASES OF 7P DELETION - CLINICAL, CYTOGENETIC, AND MOLECULAR STUDIES.

KA CHOTAILA BRUETONL VANHERWERDENC GARRETTGK HINKELA SCHINZELRF MUELLERFranki SpelemanRM WINTER

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

A MULTIMEGABASE CLUSTER OF SNRNA AND TRANSFER-RNA GENES ON CHROMOSOME 1P36 HARBORS AN ADENOVIRUS SV40 HYBRID VIRUS INTEGRATION SITE

P VANDERDRIFTA CHANNadine Van RoyGenevieve LaureysA WESTERVELDFranki SpelemanR VERSTEEG

A1 Journal Article in HUMAN MOLECULAR GENETICS

Chromosome aberations in fibrous dysplasia

P DalcinR SciotFranki SpelemanI SamsonGenevieve LaureysC De PotterFrançoise MeireB Van DammeH Van Den Berghe

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Direct transmission of a tandem duplication in the short arm of chromosome-8.

Catharina DhoogeNadine Van RoyMargarita CraenFranki Speleman

A1 Journal Article in CLINICAL GENETICS

HIGH-RESOLUTION FLUORESCENCE MAPPING OF 43 DNA MARKERS TO CHROMOSOME BAND-1P36

Nadine Van RoyP VANDERDRIFTGenevieve LaureysG OPDENAKKERR VERSTEEGFranki Speleman

I;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines

Nadine Van RoyGenevieve LaureysNgan Ching ChengPascale WillemGhislain OpdenakkerRogier VersteegFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Jumping translocation in a newborn boy with dup(4q) and severe hydrops-fetalis.

E DUVALA VANDENENDENPiet VanhaesebrouckFranki Speleman

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus.

C HILLIKERJ DELABIEFranki SpelemanG BILBEJ BRUGGENF VANLEUVENH VANDENBERGHE

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Ocular anomalies in an unbalanced translocation between chromosomes 7 and 8

G VereeckenBart LeroyFranki SpelemanMichel HanssensFrançoise Meire

A4 Journal Article in BULLETIN DE LA SOCIETE BELGE D'OPHTALMOLOGIE

Proximal deletion of chromosome-21 confirmed by in-situ hybridization and molecular studies.

W COURTENSMB PETERSENJC NOELJ FLAMENT-DURANDN VANREGEMORTERD DELNESTEP COCHAUXMR VERSCHRAEGEN-SPAENadine Van RoyFranki Speleman et al.

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

Recurrent I,17 translocations in human neuroblastoma reveal non-homologous recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.

H CARONP VANSLUISNadine Van RoyJ DEKRAKERFranki SpelemanPA VOUTEA WESTERVELDR SLATERR VERSTEEG

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17ql 1.2-ql2.

G OPDENAKKERP FITENG NYSG FROYENNadine Van RoyFranki SpelemanGenevieve LaureysJ VANDAMME

A1 Journal Article in GENOMICS

1993

EWS AND ATF-1 GENE FUSION INDUCED BY T(12-22) TRANSLOCATION IN MALIGNANT-MELANOMA OF SOFT PARTS.

J ZUCMANO DELATTREC DESMAZEAL EPSTEING STENMANFranki SpelemanCDM FLETCHERSA AURIASG THOMAS

A1 Journal Article in NATURE GENETICS

HIGH-RESOLUTION CHROMOSOMAL LOCALIZATION OF THE HUMAN CALCITONIN CGRP/IAPP GENE FAMILY MEMBERS.

JMN HOOVERSE REDEKERFranki SpelemanJWM HOPPENERS BHOLAJ BLIEKNadine Van RoyNJ LESCHOTA WESTERVELDM MANNENS

A1 Journal Article in GENOMICS

HIGH-RESOLUTION FLUORESCENCE MAPPING OF 46 DNA MARKERS TO THE SHORT ARM OF HUMAN CHROMOSOME-1.

Nadine Van RoyGenevieve LaureysR VERSTEEGG OPDENAKKERFranki Speleman

A1 Journal Article in GENOMICS

IMPROVED IMMUNOCYTOCHEMICAL DETECTION OF BIOTINYLATED PROBES WITH NEUTRALITE AVIDIN.

Nadine Van RoyK MANGELSCHOTSFranki Speleman

A1 Journal Article in TRENDS IN GENETICS

MOLECULAR CYTOGENETIC ANALYSIS OF A FAMILIAL PERICENTRIC-INVERSION OF CHROMOSOME-12.

Franki SpelemanNadine Van RoyE DEVOSC HILLIKERRFS SUIJKERBUIJKJuliaan Leroy

A1 Journal Article in CLINICAL GENETICS

MOLECULAR CYTOGENETIC CHARACTERIZATION OF MARKER CHROMOSOMES FOUND AT PRENATAL-DIAGNOSIS.

MR VERSCHRAEGEN-SPAENadine Van RoyA DEPERDIGOA DEPAEPEFranki Speleman

A1 Journal Article in PRENATAL DIAGNOSIS

1992

Detection of subtle reciprocal translocations by fluorescence in situ hibridization.

Franki SpelemanNadine Van RoyJ WIEGANTMR VERSCHRAEGEN-SPAEYves BenoitP GOVAERTL GOOSSENSJuliaan Leroy

A1 Journal Article in CLINICAL GENETICS

Familial Turner syndrome

M-R Verschraegen-SpaeHerman DepypereFranki SpelemanMarc DhontAnne De Paepe

A1 Journal Article in CLINICAL GENETICS

Fluorescentie in situ hybridisatie. Nieuwe mogelijkheden voor het chromosomenonderzoek.

Franki SpelemanNadine Van RoyJuliaan Leroy

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

i(12p) in a near-diploid mature ovarian teratoma

Franki SpelemanGenevieve LaureysYves BenoitClaude CuvelierRon SuijkerbuijkBauke De Jong

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Hendrik van EgmondR VanniNadine Van RoyU LeccaFranki Speleman

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Malignant melanoma of soft parts : further cytogenetic characterization

Franki SpelemanCecile ColpaertGerda GoovaertsJuliaan LeroyEric Van Marck

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Molecular cytogenetic analysis of a complex t (10;22;ll). Translocation in Ewing's sarcoma

Franki SpelemanNadine Van RoyJ WIEGANTAM DIERICKDirk UyttendaeleJG LEROY

A2 Journal Article in Genes, Chromosomes and Cancer, New York, nr. 4, pp. 188-191, 2 figg

Molecular cytogenetic analysis of a complex t(10;20;ll) translocation in Ewing's Sarcoma.

Franki SpelemanNadine Van RoyJ WIEGANTAM DIERICKDirk UyttendaeleJuliaan Leroy

A1 Journal Article in GENES CHROMOSOMES & CANCER

Molecular cytogenetic analysis of XX males using Y-specific DNA-sequences, including SRY

B Van der AuweraNadine Van RoyAnne De PaepeJR HawkinsI LiebaersS CastedoJ DumonFranki Speleman

A1 Journal Article in HUMAN GENETICS

Platelet-derived growth factor A chain : confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite

D BonthronT CollingsKH GrzeschikNadine Van RoyFranki Speleman

A1 Journal Article in GENOMICS

PUTATIVE MONOSOMY-21 IN 2 PATIENTS - CLINICAL FINDINGS AND INVESTIGATION USING FLUORESCENCE INSITU HYBRIDIZATION.

DL VILJOENFranki SpelemanR SMARTNadine Van RoyJ DUTOITJuliaan Leroy

A1 Journal Article in CLINICAL GENETICS

Reciprocal translocation between the proximal regions of the long arms of chromosomes 13 and 15 resulting in unbalanced offspring: characterization by fluorescence in situ hybridization and DNA analysis

Kathelijne MangelschotsBernadette Van RoyFranki SpelemanNadine Van RoyJan GheuensJoke BeutenInge BuntinxMarie-Noëlle Van ThienenHerman WillekensJan Dumon et al.

A1 Journal Article in HUMAN GENETICS

Uterine leiomyoma cytogenetics, III : interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12

R VanniNadine Van RoyU LeccaFranki Speleman

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

1991

Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization

Franki SpelemanK MangelschotsM VercruyssenP Dal CinA AventinFritz OffnerGenevieve LaureysH Van den BergheJuliaan Leroy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Assignment of the fucosidase pseudogene FUCA1P to chromosome region 2q31→q32

Paul CouckeK MangelschotsFranki SpelemanP BossuytPatric Van OostveldtB Van der AuweraB CarrittPJ Willems

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Characterization of a de novo duplication of 11p14→p13, using fluorescent in situ hybridization and Southern hybridization

Franki SpelemanM MannensB RedekerM VercruyssenPatric Van OostveldtJuliaan LeroyR Slater

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

De ovariële functie bij het Turner syndroom

Herman DepypereAnne De PaepeMR Verschraegen-SpaeFranki SpelemanMarc DhontDirk Vandekerckhove

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Extra translocation t(lq9p) is a prognostic indicator in myeloproliferative disorders

G RegecambrinFranki SpelemanS KerimP ScaravaglioF CarozziP DalcinJL MichauxFritz OffnerG SaglioH Vandenberghe

A1 Journal Article in LEUKEMIA

Is T(6-20)(P2L-QL3) a characteristic chromosome change in endometrial polyps

Franki SpelemanP DalcinNadine Van RoyE VanmarckP BuytaertH VandenbergheJG Leroy

A1 Journal Article in GENES CHROMOSOMES & CANCER

Pallister-Killian syndrome: characterization of the isochromosome 12p by fluorescent in situ hybridization

Franki SpelemanJuliaan LeroyNadine Van RoyAnne De PaepeR SuukerbuukJ BrunnerL LooijengaM Verschraegen-SpaeE Orye

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS

The distal region of 11p13 and associated genetic diseases

M MannensJMN HooversEM Bleeker-WagemakersE RedekerJ BliekM Overbeeke-MelkertG SaunersB WilliamsV van HeynigenC Junien et al.

A1 Journal Article in GENOMICS

1990

CONSTITUTIONAL TRANSLOCATION T(1-17)(P36-Q12-21) IN A PATIENT WITH NEUROBLASTOMA

Genevieve LaureysFranki SpelemanG OPDENAKKERYves BenoitJuliaan Leroy

A1 Journal Article in GENES CHROMOSOMES & CANCER

i(12p) in a malignant ovarian tumor

Franki SpelemanChristian De PotterPaola Dal CinKathelijne MangelschotsHerwig IngelaereGenevieve LaureysYves BenoitJules LeroyHerman Van Den Berghe

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Identification and characterization of normal length nonfluorescent Y chromosomes: cytogenetic analysis, Southern hybridization and non-isotopic in situ hybridization

Franki SpelemanBart Van der AuweraKathelijne MangelschotsMiet VercruyssenTon RaapJoop WiegantMargarita CraenJuliaan Leroy

A1 Journal Article in HUMAN GENETICS

1989

Cytogenetic analysis of a mesenchymal hamartoma of the liver

Franki SpelemanVeronique De TelderKristiaan R De PotterPaola Dal CinSabine Van daeleYves BenoitJules G LeroyHerman Van Den Berghe

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Cytogenetic investigation of a case of congenital fibrosarcoma

Franki SpelemanPaola Dal CinKristiaan De PotterGenevieve LaureysHendrik RoelsJuliaan LeroyHerman Van Den Berghe

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

De novo terminal deletion 7P22.1-pter in a child without craniosynostosis

Franki SpelemanMargarita CraenJuliaan Leroy

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Genetics in Ophthalomology. Chapter VI: Cytogenetics: Chromosomal Aberrations and Ocular Abnormalities, plO6-l 19. Editor F. Meire, 1998.

Franki Speleman