Project

Selection of driver genes and neuronal differentiation gene modules in neuroblastoma through an integrated genomic analysis

Code

3F015911

Duration

01 October 2011 → 10 October 2014

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Franki Speleman

Fellow

Annelies Fieuw

Research disciplines

Natural sciences
- Scientific computing
- Bioinformatics and computational biology
- Genetics
- Systems biology
Medical and health sciences
- Bioinformatics and computational biology
- Molecular and cell biology
- Bioinformatics and computational biology
- Public health care
- Public health services
- Bioinformatics and computational biology
- Molecular and cell biology
Engineering and technology
- Scientific computing

Keywords

integrated analysis next-generation sequencing neuroblastoma

Project description

Integrative genomic analyses and pathway reconstruction efforts will be implemented to the currently used set of analytical tools as an original and powerful approach to discriminate driver from passenger mutations in the next-generation sequencing of neuroblastoma tumor samples. Gene modules will be obtained and those implicated in normal sympathetic neuronal differentiation will be prioritized for further functional analyses.