Research Explorer

Project

Molecular therapy of neuroblastoma: a p53-oriented appraoch
Code
3E005311
Duration
01 October 2011 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
nutlin-3 molecular therapy p53 neuroblastoma
 
Project description
 

The p53 tumor suppressor pathway offers attractive opportunities for targeted therapy of neuroblastoma. We will try to initiate a clinical trial with the p53-activating drug nutlin-3 in neuroblastoma, characterize noncoding RNA molecules and SNPs that affect the p53 network in neuroblastoma, investigate how the MYCN oncogene alters the p53 response to chemotherapy, and identify new targets for molecular therapy.