Project

Identification of causal mutations in patients with unexplained mental retardation and congenital abnormalities by high throughput sequencing of selected candidate genes

Code
3F020108
Duration
01 October 2008 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Scientific computing
    • Bioinformatics and computational biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Public health care
    • Public health services
    • Bioinformatics and computational biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
  • Engineering and technology
    • Scientific computing
Keywords
mental retardation sequencing genetics
 
Project description

Chromosomal aberrations as well as pointmutations are an important cause of mental retardation and multipele congenital abnormalities (MR/MCA). In this project, the newest technologies in human genetics (selective resequencing) will be used to resequence 3000 candidate genes for MR/MCA in order to understand the underlying cause of MR/MCA and to gain insights in normal human embryogenesis.