Code
3F003909
Duration
01 October 2009 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Molecular and cell biology
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology
- Molecular and cell biology
- Morphological sciences
- Oncology
Keywords
PHF6
T-ALL
genetics
Project description
T-ALL is an agressive malignancy that develops in the thymus and is characterized by an uncontrolled division of immature T-cells. Recently, we identified deletions and inactivating mutations of the PHF6 gene in ~20% male T-ALL patients and ~25% male T-ALL cell lines. The exact function of this transcription factor and his role in the development of T-ALL are not known.