Code
01P06407
Duration
01 October 2007 → 01 October 2008
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
- Systems biology
-
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology
Keywords
molecular therapy
neuroblastoma
JAK/STAT pathway
Project description
Evaluation of JAK/STAT pathway inhibitors on neuroblastoma (NB) cell-lines revealed a dramatic reduction in cell viability in comparison to control cells. Further characterisation of the cellular effects and identification of the actual targets of the tested compounds can provide important insights in the critically deregulated pathways in NB and can implicate a fundamental acquisition for the future treatment of NB.