Research Explorer

Project

Epigenetic re-activation of T-ALL tumor suppressors under control of TLX1driven enhancer RNAs.
Code
01D22015
Looptijd
01-10-2015 → 30-09-2019
Financiering
Regional and community funding: Special Research Fund
Onderzoeksdisciplines
  • Natural sciences
    • Genetics
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Trefwoorden
epigenetica lncRNAs enhancers T-ALL TLX1
 
Projectomschrijving
 

In this project, I will further explore the oncogenic role of TLX1 in the development of T-cell acute lymphoblastic leukemia. This research will explore a network connecting TLX1 with long noncoding RNAs and tumor suppressor genes. Ultimately, this should allow identification new vulnerable nodes for targeted therapy of TLX1-driven T-ALLs.