The role of the ETS transcription factor ETV5 as executer of ALK oncogenic signaling

01 October 2012 → 30 September 2016
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biophysics
    • Biophysics
    • Biophysics
anaplastic large cell lymphoma ETS transcription factor non small cell lung cancer ALK cancer ETV5 neuroblastoma receptor tyrosine kinase
Project description

Genetic alterations in the ALK receptor tyrosine kinase gene are related to the development and the acquisition of therapy resistance of various cancers, among which neuroblastoma, a common pediatric malignancy. This project aims to characterize the function of the oncogenic transcription factor ETV5 in ALK driven tumor formation and to establish new frontiers for the development of ALK downstream oriented targeted therapies.