A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN)

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

Antibody-oligonucleotide conjugation for cellular delivery of oligonucleotides

A Tale of Furan and Nucleic Acids:  The exploration of furan chemistry as a versatile tool for targeting oligonucleotides

Crosslinked G-quadruplexes as nucleic acid decoys for protein interaction studies

Crosslinking Aptamers for Covalent Protein Targeting

Cyclodextrin-Nanobody Conjugates: A Peptide Delivery System to Harness the Anticancer Potential of Cyclic Lipopeptides

Design and synthesis of peptide nucleic acid probes for nucleic acid biomarker detection with enhanced selectivity

Design of capture and detection probes for photo-electrochemical detection of cancer nucleic acid biomarkers

Developing Furan and Triazolinedione Chemistries for Site-Selective Protein Modification

Development of new bioconjugation methods for protein and nucleic acid conjugates

Doctoral project Abhishek Iyer

Doctoral project Ana Margarida Dias Carvalho Da Rocha

Doctoral project Dorien Aerssens

Doctoral project Dorien Van Lysebetten

Doctoral project Eirini Antonatou

Doctoral project Ellen Gyssels

Doctoral project Eva Marina Llamas Garcinuño

Doctoral project Fabiana Cavallini

Doctoral project Jan Elskens

Doctoral project Kurt Hoogewijs

Doctoral project Lars Verdonck

Doctoral project Lieselot Carrette

Doctoral project Mahmoud Nabil Mahmoud Yousif

Doctoral project Marieke Op de Beeck

Doctoral project Nathalie De Laet

Doctoral project Sara Figaroli

Doctoral project Vicky Gheerardijn

Doctoral project Vincent Ornelis

Doctoral project Willem Vannecke

Doctoral project Yara Ruiz Garcia

Enlarging the toolbox for cysteine selective protein modification

Exploitation of nucleic acid crosslinking approaches for improved RNA capture and aptamer stabilization

Exploiting the covalent triazolinedione and furan chemistry toolbox for labelling, crosslinking and degradation of proteins

Furan and porphyrin containing crosslinking ligands for covalent stabilisation of G quadruplexes as cell-permeable anti-cancer aptamers

GlyConnect: exploring glycan-based conjugation chemistries for GlycoDelete proteins

Host microRNAs in SARS-Coronavirus 2 infection: from pathophysiology to treatment

Investigation of the Biogelator platform for the controlled delivery of biological therapeutics

In vitro assay development for ON spatial conformer analysis and isolation

Plaatsspecifiek modificatie van proteïnen voor vaccin ontwikkeling

Synthesis of modified PNA probes for sequence-selective G-quadruplex photoalkylation

An integrated approach towards increasing aptamer robustness by incorporation of an imidazolium modified thymine

Creating clarity in the structural diversity of <i>Pseudomonas</i> lipopeptides and in their associated membrane perturbing effect

Development of a photoelectrochemical singlet oxygen-based platform for the rapid detection of DNA and RNA biomarkers

Doctoral project Matthias De Vleeschouwer

Doctoral project Steven Martens

Doctoral project Tim Van Kersavond

Exploration of the importance of acyl chains for the bioactivity of Cyclic Lipodepsipeptides from Pseudomonas bacteria

<i>Pseudomonas</i> Cyclic Lipopeptides as Cytotoxic Agents for Cancer Cells: Structure-Function Analysis

Sequence-defined macromolecules: From linear to precise three-dimensional architectures

Structure, Function and Interaction of Tolaasin

Unravelling the secrets of aptamer−small molecule complexes with NMR spectroscopy - the TESS.1 aptamer case

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

Antibody-oligonucleotide conjugation for cellular delivery of oligonucleotides

A Tale of Furan and Nucleic Acids: A journey through the exploration of furan chemistry as a versatile tool for nucleic acid targeting.

Biomimetic furan oxidation: a "Trojan Horse" strategy for the formation of covalent protein / protein complexes.

Chemical and enzymatic bioconjugation for the site-specific decoration of proteins with therapeutic property enhancing moieties

Cofunding core facility - NMR Expertise Centre

Conformationally locked G4-decoy oligonucleotides for selective telomerase inhibition and development of a nucleic acid-based anti-telomerase PROTAC strategy

Crosslinking Aptamers for Covalent Protein Targeting

Crosslinking Aptamers for Covalent Protein Targeting

Design and synthesis of cyclic peptides with improved therapeutic potential by molecular grafting of peptide loop sequences onto steroid scaffolds

Design, synthesis and screening of tRNA stabilising and antigenomic compounds for the treatment of mitochondrial diseases.

Design, synthesis and screening of tRNA stabilising and antigenomic compounds for the treatment of mitochondrial diseases.

Detection of DNA-peptide interactions via crosslinking: versatile use of the furan oxidation methodology

Detection of DNA-peptide interactions via crosslinking: versatile use of the furan oxidation methodology.

Development of a Hydrogel Platform for Controlled Delivery of Biologicals

Development of new types of DNA-binding peptides

EnergyEfficiency (EnEf)

Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.

Exploring the chemical potential of Therapeutic Alpha Antibodies

Furan and porphyrin containing crosslinking ligands for covalent stabilisation of G quadruplexes as cell-permeable anti-cancer aptamers

Furan and triazolinedion based strategies for site-specific labeling, conjugation and cross-linking of native and recombinant proteins.

Furan-based Artificial DNA Anchoring Systems

Furan crosslinking for improved sensitivity in diagnostic assays

Furan-modified peptide and protein ligands for covalent trapping onto cell-surface receptors

Hooked to the opioid receptor: covalent ligands as novel tools to study mu opioid receptor signaling

MEFuran

MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes

Microwave assisted synthesis of peptide dipodale steroids as artificial transcription factors with increased bioavailability

MOLECULAR DESIGN OF ‘FROZEN’ APTAMERS: Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach

Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Novel cross-link technologies to probe peptied-ligand/receptor interactions

Oligonucleotides for Medical Applications

Optimization of furan-oxidation crosslinking methodology for new applications in nucleic acid crosslinking

Proprietary “Next Generation Maleimide Chemistry” for Bioconjugation

Rational design of a receptor for the detection of the mycotoxin beauvericin and enniatin A, A1, B, B1

Recognition and cleavage of Biological Phosphates, Molecular Recognition, Mechanism and Biomedical Applications

SANI: Generation of Stable, Addressable multi-Nanobody Immunoarrays through oriented covalent immobilisation

Synthesis and Optimization Strategies of Bioengineered Cyclic Peptides for Improving Therapeutic Drug Profiles

Synthesis of furan-modified nucleic acid probes for the development of new RNA target identification strategies.

Synthesis of modified PNA probes for sequence-selective G-quadruplex photoalkylation.

Synthetic Antibodies as innovative receptors in sample pretreatment and diagnostics applied to emerging toxic cyclic depsipeptides in the food chain

Synthetic antibodies (SynAbs) for detection of cyclodepsipeptide toxins in food

Synthetic antibody (SynAb) receptors for the detection and isolation of cyclic depsipeptide (CDP) toxins in food samples.

Target identification for orphan peptides through furan-oxidation based cross-linking for application in cancer research

The Singlet Oxygen Strategy: sustainable oxidation procedures for applications in material science, synthesis, wastewater treatment, diagnostics and therapeutics

Visible light induced nucleic acid crosslinking: development of self-activatable oligonucleotide probes

3D Structural Platform for Chemical Excellence.

A MALDI-TOF/TOF MS instrument for (bio)polymer characterization and imaging.

BioGelator for local immunotherapy

Development of methods for enrichment and analysis for trace analysis of endocrine disrupting chemicals in water samples mediated by synthetic selective receptors

Development of synthetic selective receptors for the enrichment and trace determination of endocrine disrupting chemicals in water samples

Evaluation of new types of stationary phases and column dimensions for the development of highly efficiënt and generic supercritical fluid chromatography

From multi-functionalized oligomers to sequence controlled polymers: towards unprecedented control of synthetic macromolecules

From multi-functionalized oligomers to sequence controlled polymers: towards unprecedented control of synthetic macromolecules

LC-'Single Quadrupole MS' for analysis of reaction mixtures and organic compounds with determination of their molecular mass and purity.

Molecular design of imidazole enhanced nucleic acid aptamers and DNAzymes based upon a modeling-synthesis-analysis toolbox

Molecular engineering of peptide-based hydrogels for sustained drug release

ReHiFiNMR - Rejuvenation of High-Field NMR equipment for the continued and enhanced characterization of complex molecular architectures and their interactions

Reptide hydrogels comprising beta-amino acids

Routine NMR Analysis Equipment for Small Molecule Characterisation.

Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciences

Structure-function study with NMR of and insight into the supramolecular assembly of lipopeptide antibiotics from the viscosin group.