This proposal requests funding for a micro-Isothermal Titration Calorimeter (micro-ITC), a sensitive, label-free technique that quantifies heat changes during intermolecular interactions. Micro-ITC provides direct access to key thermodynamic parameters (ΔH, ΔS, ΔG, KA) and interaction stoichiometry, offering deep insight into reversible interactions in supramolecular systems governed by weak forces. Despite its relevance to the applicants’ research on supramolecular assemblies and materials, such equipment is currently not available at UGent for chemical research, forcing reliance on external collaborations and limiting usage. As the basic demand for thermodynamic fingerprinting of intermolecular interactions in the applicants’ research steadily increases, lack of micro-ITC places an increasing limit on the applicants’ research progress. The investment will therefore significantly enhance research capacity, enable wider adoption of micro-ITC at UGent, and foster new collaborations.