Project

Design, synthesis and screening of tRNA stabilising and antigenomic compounds for the treatment of mitochondrial diseases.

Acronym
3PL002816
Duration
01 April 2017 → 31 March 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
peptides Peptide nucleic acids peptidomimetics
 
Project description

To generate energy, mitochondria build their own machinery, using mitochondrial DNA (mtDNA) as a blueprint. Mutations in the mtDNA are rare, but lead to severe and progressive diseases often with fatal outcome. In this project, we will design molecules which stabilise defective nucleic acid components of the mitochondrial translational machinery. In addition, we will attempt to specifically remove mutant mtDNA.