This project concerns the replacement of an automated DNA synthesizer. Due to the recent success of nucleic acid-based vaccines, the development of novel nucleic acid-based diagnostic probes and therapeutics is strongly increasing and offers promising opportunities for medical applications. Within the Organic and Biomimetic Chemistry research (OBCR) group, expertise has been built up over many years in the use of advanced chemical strategies to improve the stability, specificity and functionality of oligonucleotide probes. The individual building blocks for building oligonucleotides are typically assembled via automated solid phase synthesis, given their sensitivity.

The successful research within OBCR in this context has led to a series of interdisciplinary, interfaculty collaborations in which modified oligonucleotides are used in various applications. The results of the collaborations can contribute to faster and more accurate diagnostics, as well as effective therapeutic interventions for various diseases.