Project

Chemical and enzymatic bioconjugation for the site-specific decoration of proteins with therapeutic property enhancing moieties

Code
01D33718
Duration
01 October 2018 → 30 September 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
Bioconjugation peptide synthesis enzymatic ligation
 
Project description

Though biologicals have enhanced recognition and targeting capabilities, their use can be severely hampered by the fact that they are easily degraded or eliminated in a biological environment.
In the current project we aim to develop chemical and chemoenzymatic tools and methodologies for the modification of such biological molecules to enhance their properties in terms of stability, uptake in cells, circulation times and half-life.