Project

MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes

Acronym
MemCLiP
Code
01G02819
Duration
01 January 2019 → 31 December 2022
Funding
Regional and community funding: Special Research Fund
Promotor-spokesperson
Research disciplines
  • Natural sciences
    • Structural analysis
    • Bio-organic chemistry
    • Analytical biochemistry
    • Lipidomics
  • Medical and health sciences
    • Lipids
    • Lipids
    • Regulation of metabolism
Keywords
Lipopeptides fluorescent labeling and tracking solid phase synthesis structure analysis plant cell suspension cultures innate immunity in plants bioactivity and control anti tumor cell activity
 
Project description

The activity of cyclic lipopeptides, produced by Pseudomonas bacteria and chemically synthesized analogues will be tested in a standardized way on human (healthy and cancer) cells, plant cell suspensions and fungal cells. Using a combination of biological and (physico-)chemical methods we will test the hypothesis that in all these eukaryotic cells, these lipopeptides act on lipids in the cell membranes.