The presented interdisciplinary research project tackles challenging issues in the emerging field of

sequence-controlled (macro)molecules and related single chain nanotechnology. The first hurdle is

the efficient synthesis of sequence-defined motifs with sufficient length. Therefore, a novel solidsupported

chemical protocol is described as it allows for the protecting group-free preparation of

various multifunctionalized oligomers, based on a single building block. Next to variations in the

chain length and the identity of pendent side groups, control over the stereochemistry and highthroughput

automation will be targeted.

In the next stage, the newly synthesized oligomeric species will be structurally modified, as several

topological upgrades (sequence-controlled polymers, cyclic analogues and single chain functional

systems) are envisaged. Following these dedicated synthetic efforts, evaluation of unprecedented

properties of the multifunctionalized sequence-defined oligomers and derivatives, in-depth

modeling and characterization of the dynamic systems, should provide relevant insights regarding

their conformational flexibility and supramolecular behavior.

Finally, the linear sequence-controlled polymers will serve as scaffolds for immobilizing (bio)

chemical substrates, resulting in polymeric materials with sharply defined structure/activity

relationships.