Supercritical Fluid Chromatography (SFC) is a technique combining the chromatographic benefits of GC and the broad applicability of HLC. Supercritical fluids offer many interesting characteristics. The goal of this project is to evaluate the performance of SFC and compare it to HPLC, to assist to the optimization and valorisationo of the current SFC hardware, to desing taylor made stationary phases for SFC by click-chemistry and to develop generic SFC methods.