Trough synthesis of major groove binding peptides incorporating an unnatural furan-amino acid building block, we will try to achieve DNA-peptide cross-linking. More specificallay, we have chosen to work on a modelsystem that was developed at Kyoto University and that can ben synthetically modified with the desired crosslinking functionality. After complexation of peptide with the DNA-duplex, the furan moeity will be oxidized to a reactive enal functionality. Subsequent reaction with the nucleophilic exocyclic amines of DNA bases in major groove will lead to the desired cross-link reaction.