Role and mechanism of caspase-3/7 as checkpoint for intestinal inflammation and regeneration

Cell Death Regulation and Role in Infection and Inflammatory Diseases

Mechanisms of ferroptosis mediated immunoregulation

Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy

Stichting tegen Kanker: Advanced technology equipment: Small Animal Radiation Therapy platform (SmART+)

Investigating the immunoregulatory properties of ferroptosis in experimental cancer models

Thymic reprogramming: Systemic inflammation changes the cellular output of the thymus from T cells to NK cells and iron-binding myeloid cells

Elucidate the role of death receptor 3 (DR3) in thymic immune activation in infectious disease

Identification of cellular mechanisms of radiotherapy-induced immunogenicity

Capacity building of a compound screening facility for Cuban-developed bioactive compounds targeting cell death and inflammation

Factors that determine RIPK1-dependent necroptosis

MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection

Relation between energy and redox metabolism and regulated necrosis during EMT: an opportunity for experimental cancer therapy.

DR3 – a Novel Inducer of Necroptosis and Mediator of Intestinal Inflammation and Pathology

Center for Bioassay Development and Screening (C-BIOS)

RIPK1 in T-cells: an interplay between cell death signalling and immunity

Study of the contribution of different modes of regulated necrosis in acute liver injury and lethal shock 

Role of dead cell clearance in resolution of inflammation and tissue regeneration 

Unraveling the in vivo role of RIPK1: Physiological and pathological consequences of kinase-dependent and kinase-independent functions 

Determining the role and mode of cell death in Necrotizing Enterocolitis

Role and mechanism of RIPK1 during immunogenic cell death by necroptosis

Spatio-temporal aspects and function of MLKL at plasma membrane during necroptosis.

Necroptotic proteins in diseases: targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Study of the molecular mechanisms of execution MLKl in necroptosis

Damage-associated molecular patterns: are they bona fide immunogenic signals or do they simply assist/augment the antigenicity or cancer cells?

Exploiting necroptosis targeting in cancer therapy: High content screening and validation

IAP Antagonists Synergise with IFNy to Activate Novel RIPK1 and Caspase Mediated Death Pathways in Cancer Cell Lines

Identification, lead optimization and validation of necroptosis inhibitors

exploration of immunogenicity of apoptosis, necroptosis and autophagy in experimental anti-cancer treatments

Identification and characterization of new DAMPs during immunogenic apoptosis

Study of molecular determinants of RIP1-kinase for cellular stress responses and metabolic regulation

Molecular Signaling in Cell Death and Inflamation: an integrative approach from basic mechanisms to disease models

Necroptosis, a well controlled cell death modality – its role in tumor development and how to exploit this therapeutically

Study of the influence of (recently identified) regulators on necroptosis (oxidative) metabolism

role of DAMPs in the immunomodulation and regeneration of the intestinal epithelium.

Use of biosensors for necrotic cell death

Identification and validation of molecular mechanisms involved in necrotic cell death

Apoptosis, necrosis and autophagy: a comparative study of the impact dying cells on innate immunity

Identification of RIP3 substrates and their role in necrotic cell death.

NRAGE, a novel regulator of RIP2 dependent NOD signaling in immune responses

Euregional Platform for Advancing Cancer Treatment II

Cell death activity regulation in inflammation and cancer

Apoptosis, necrosis and autophagy: a comparative study of the impacht of dying cells on innate immunity

Identification and validation of protein substrates and interactors of RIP1 during necrotic cell death

Interaction of apoptotic, necrotic and autophagic cells with innate immune system: a comparative study

Research into the role and mechanism of caspase-7 in immunomodulation and in immunopathologies

Enhancing DNA vaccine efficacy by coexpression of viral antigen and cell death modulating proteins

Caspase-mediated apoptosis and inflammation during a rabies virus infection: a model for the study of pathogenesis, and new treatments for viral encephalitis

Study of the function of caspase-14 and RIP4 in epidermal differentiation.

Study of the in vivo role of effector caspases (patho-) physiological model systems.

Identification of danger signals form dying cells and study of Their immunomolulatory effects.

Study of the in vivo role of effector caspases (patho-) physiological model systems.

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Investigating Trans-Generational Training Networks in Central Africa: A Multi-Layered Analysis of Pottery Technology

Investigating the role of rivers during the Late Glacial recolonization of NW Europe: a multidisciplinary assessment of Final Palaeolithic sites in the Scheldt valley (Belgium)

Development of a micro-spatially offset Raman spectroscopy (micro-SORS) probe for the in situ characterisation of layered structures

Proteases in inflammation and cell death

Identification, lead optimization and validation of necroptosis inhibitors

The role of connexin-mediated intercellular signaling in the spread of danger and death signals between brain endothelial cells

The role of peroxisomes in the inflammatory responses

Total-relfexion X-ray Fluorescence (TXRF) instrumentation

Danger-associated molecular patters: revealing the molecular signals dictating the communication between dying cells with the immune system

Study of the molecular role of caspase-14 using transgenic Mouse models

Signal transduction in inflammation: from gene to organism

Role of ZBP1 signalling in doxorubicin-mediated anticancer immunity and drug-induced pathology