01 January 2013 → 31 December 2018
Research Foundation - Flanders (FWO)
Medical and health sciences
connexins cell death inflammation intercellular communication IP3/calcium signaling
We here aim to investigate how intercellular calcium communication via connexin channels can contribute to the emission of damage-associated molecular patterns (DAMPs) and spread of cell death signals between brain tumor endothelial cells. Our working hypothesis is that the communication of DAMPs and death signals can promote microvascular damage inflicted by radiation therapy, thereby promoting more efficient brain tumor involution.