Project

The role of connexin-mediated intercellular signaling in the spread of danger and death signals between brain endothelial cells

Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Physiology
    • Immunology
    • Physiology
    • Immunology
    • Physiology
Keywords
connexins cell death inflammation intercellular communication IP3/calcium signaling
 
Project description

We here aim to investigate how intercellular calcium communication via connexin channels can contribute to the emission of damage-associated molecular patterns (DAMPs) and spread of cell death signals between brain tumor endothelial cells. Our working hypothesis is that the communication of DAMPs and death signals can promote microvascular damage inflicted by radiation therapy, thereby promoting more efficient brain tumor involution.