Project

Cell death activity regulation in inflammation and cancer

Acronym
Cedar-ic
Duration
01 January 2009 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
 
Project description

The project aims at a global and integrated approach of the 4 major types of cell death (apoptosis, necrosis, autophagic cell death, pyroptosis) on four levels: the biochemistry of caspases and RIP kinases, the intracellular signal transduction, the intercellular communication and its role in experimental diseaese models using transgenic animals. We will use global approaches involving shRNA, siRNA and miRNA screenings, interactomics, degradomics, phosphoproteomics and bioinformatics.