Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy

Cell Death Regulation and Role in Infection and Inflammatory Diseases

Mechanisms of ferroptosis mediated immunoregulation

Role and mechanism of caspase-3/7 as checkpoint for intestinal inflammation and regeneration

Doctoral project Aleksandra Czekaj

Doctoral project Charlotte Volgers

Doctoral project Eline Meul

Doctoral project Fabienne Le Cann

Doctoral project Jolien Bridelance

Doctoral project Marco Dalla Vecchia

Doctoral project Michael Devos

Doctoral project Samya Van Coillie

Doctoral project Simon Verdonck

Doctoral project Sofie Martens

Doctoral project Tania Love Aaes

Doctoral project Yves Dondelinger

Elucidation of the role of GSDME during apoptosis-driven secondary necrosis

Exploring the role of RIPK1 in T cell homeostasis

Het herprogrammeren van de thymus: Systemische inflammatie instrueert de thymus tot de ontwikkeling van myeloïde en natural killer (NK) cellen

Impact of epithelial-to-mesenchymal transition on regulated cell death and immune activation in colorectal carcinoma

Investigating the immunoregulatory properties of lipid peroxidation following irradiation

Investigating the role of MLKL and EVs in cell-cell communication during necroptosis

Therapeutic exploration of ferroptosis in multiple sclerosis

The role of lipid peroxidation in cell death and adaptive immune system regulation

Thymus development during acute inflammation

Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy

Doctoral project Corinne Urwyler

Doctoral project Miguel Aguileta

Apoptosis, necrosis and autophagy: a comparative study of the impacht of dying cells on innate immunity

Apoptosis, necrosis and autophagy: a comparative study of the impact dying cells on innate immunity

Capacity building of a compound screening facility for Cuban-developed bioactive compounds targeting cell death and inflammation

Caspase-mediated apoptosis and inflammation during a rabies virus infection: a model for the study of pathogenesis, and new treatments for viral encephalitis

Cell death activity regulation in inflammation and cancer

Center for Bioassay Development and Screening (C-BIOS)

Damage-associated molecular patterns: are they bona fide immunogenic signals or do they simply assist/augment the antigenicity or cancer cells?

Determining the role and mode of cell death in Necrotizing Enterocolitis

DR3 – a Novel Inducer of Necroptosis and Mediator of Intestinal Inflammation and Pathology

Elucidate the role of death receptor 3 (DR3) in thymic immune activation in infectious disease

Enhancing DNA vaccine efficacy by coexpression of viral antigen and cell death modulating proteins

Euregional Platform for Advancing Cancer Treatment II

Exploiting necroptosis targeting in cancer therapy: High content screening and validation

exploration of immunogenicity of apoptosis, necroptosis and autophagy in experimental anti-cancer treatments

Factors that determine RIPK1-dependent necroptosis

IAP Antagonists Synergise with IFNy to Activate Novel RIPK1 and Caspase Mediated Death Pathways in Cancer Cell Lines

Identification and characterization of new DAMPs during immunogenic apoptosis

Identification and validation of molecular mechanisms involved in necrotic cell death

Identification and validation of protein substrates and interactors of RIP1 during necrotic cell death

Identification, lead optimization and validation of necroptosis inhibitors

Identification of cellular mechanisms of radiotherapy-induced immunogenicity

Identification of danger signals form dying cells and study of Their immunomolulatory effects.

Identification of RIP3 substrates and their role in necrotic cell death.

Interaction of apoptotic, necrotic and autophagic cells with innate immune system: a comparative study

Investigating the immunoregulatory properties of ferroptosis in experimental cancer models

MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection

Molecular Signaling in Cell Death and Inflamation: an integrative approach from basic mechanisms to disease models

Necroptosis, a well controlled cell death modality – its role in tumor development and how to exploit this therapeutically

Necroptotic proteins in diseases: targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

NRAGE, a novel regulator of RIP2 dependent NOD signaling in immune responses

Relation between energy and redox metabolism and regulated necrosis during EMT: an opportunity for experimental cancer therapy.

Research into the role and mechanism of caspase-7 in immunomodulation and in immunopathologies

RIPK1 in T-cells: an interplay between cell death signalling and immunity

Role and mechanism of RIPK1 during immunogenic cell death by necroptosis

role of DAMPs in the immunomodulation and regeneration of the intestinal epithelium.

Role of dead cell clearance in resolution of inflammation and tissue regeneration 

Spatio-temporal aspects and function of MLKL at plasma membrane during necroptosis.

Stichting tegen Kanker: Advanced technology equipment: Small Animal Radiation Therapy platform (SmART+)

Study of molecular determinants of RIP1-kinase for cellular stress responses and metabolic regulation

Study of the contribution of different modes of regulated necrosis in acute liver injury and lethal shock 

Study of the function of caspase-14 and RIP4 in epidermal differentiation.

Study of the influence of (recently identified) regulators on necroptosis (oxidative) metabolism

Study of the in vivo role of effector caspases (patho-) physiological model systems.

Study of the in vivo role of effector caspases (patho-) physiological model systems.

Study of the molecular mechanisms of execution MLKl in necroptosis

Thymic reprogramming: Systemic inflammation changes the cellular output of the thymus from T cells to NK cells and iron-binding myeloid cells

Unraveling the in vivo role of RIPK1: Physiological and pathological consequences of kinase-dependent and kinase-independent functions 

Use of biosensors for necrotic cell death

Danger-associated molecular patters: revealing the molecular signals dictating the communication between dying cells with the immune system

Development of a micro-spatially offset Raman spectroscopy (micro-SORS) probe for the in situ characterisation of layered structures

Identification, lead optimization and validation of necroptosis inhibitors

Investigating the role of rivers during the Late Glacial recolonization of NW Europe: a multidisciplinary assessment of Final Palaeolithic sites in the Scheldt valley (Belgium)

Investigating Trans-Generational Training Networks in Central Africa: A Multi-Layered Analysis of Pottery Technology

Proteases in inflammation and cell death

Signal transduction in inflammation: from gene to organism

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Study of the molecular role of caspase-14 using transgenic Mouse models

The role of connexin-mediated intercellular signaling in the spread of danger and death signals between brain endothelial cells

The role of peroxisomes in the inflammatory responses

Total-relfexion X-ray Fluorescence (TXRF) instrumentation

Role of ZBP1 signalling in doxorubicin-mediated anticancer immunity and drug-induced pathology