Project

Study of the function of caspase-14 and RIP4 in epidermal differentiation.

Duration
01 January 2008 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Microbiology
  • Medical and health sciences
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
cornification keratinocyte epidermal differentiation Receptor Interacting Protein caspase
 
Project description

Caspase-14 plays an important role in epidermal terminal differentation (=cornification), while Receptor Interacting Protein-4 (RIP4) deficient mice display a general defect in keratinocyte differentiation. We will study the molecular signal transduction pathways leading to these phenotypes. Therefore, we will make use of in vitro and in vivo models.