Project

Damage-associated molecular patterns: are they bona fide immunogenic signals or do they simply assist/augment the antigenicity or cancer cells?

Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
Keywords
apoptosis ATP calreticulin Inflamation
 
Project description

A limited set of anticancer treatments (like some chemotherapeutics, gamma irradiation and photodynamic therapy) induce an immunogenic cel death (ICD) associated with emission of 'Dammage-Associated Molecular Patterns' (DAMPS). We want to fully understand the role of calreticulin and ATP in ICD, to identify (new) immunomodulators associated with this cell death subroutine and to analyze the receptors that sese these immunological effectors