Code
3G060713
Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Medical and health sciences
- Immunology
- Morphological sciences
- Oncology
- Immunology
- Morphological sciences
- Oncology
- Immunology
- Morphological sciences
- Oncology
Keywords
apoptosis
ATP
calreticulin
Inflamation
Project description
A limited set of anticancer treatments (like some chemotherapeutics, gamma irradiation and photodynamic therapy) induce an immunogenic cel death (ICD) associated with emission of 'Dammage-Associated Molecular Patterns' (DAMPS). We want to fully understand the role of calreticulin and ATP in ICD, to identify (new) immunomodulators associated with this cell death subroutine and to analyze the receptors that sese these immunological effectors