Project

Use of biosensors for necrotic cell death

Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
biosensors RIP kinases necrosis
 
Project description

This project implies a fundamental research program on the molecular mechanisms of necrotic cell death and the development of cellular reporter systems for carbohydrate metabolism and RIP1/RIP3 activation for RNAi and small compound library screening. As such, this platform becomes a powerful tool to identify critical nodes of the signaling network and markers for necrosis with potential diagnostic, prognostic and therapeutic use in fundamental and experimental therapeutic research.