Project

role of DAMPs in the immunomodulation and regeneration of the intestinal epithelium.

Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Medical imaging and therapy
    • Medical imaging and therapy
    • Social medical sciences
    • Medical imaging and therapy
Keywords
cell death intestine DAMPs epithelium
 
Project description

The process of intestinal cell death is well-regulated to ensure homeostasis and does normally not elicit an immune response. however, a number of diseases can be attributed to problems with cell death. it is postulated that initiation ofr sustainment of these diseases may be associated with the release of damage Associated moleculatr patterns (DAMPs) by dying cells. the main goal of the current project is to develop a DAMP discovery and validation pipeline. Identification and analysis of effects exhibited by DAMPs will elucidate important mechanisms of innate immunity, and gerate novel biomarkers of cell death, inflammation and rissue regeneration.