Project

Study of the molecular role of caspase-14 using transgenic Mouse models

Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Microbiology
  • Medical and health sciences
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
    • Dermatology
    • Medical biochemistry and metabolism
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
epidermal differentiation keratinocyte caspase
 
Project description

The epidermis, which forms the uppermost, multilayered compartment of the skin, has evolved to provide a physical and permeability barrier, which is essential for survival and to prevent microbial invasion. Our work has shown that caspase-14 plays an important role in the correct formation of the skin barrier. Now we want to investigate the molecular mechanisms leading to this phenotype, using different in vivo model systems.