Enhancing DNA vaccine efficacy by coexpression of viral antigen and cell death modulating proteins

15 August 2008 → 15 June 2009
Federal funding: various
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Immunology
nucleoprotein necrosis apoptosis
Project description

DNA vaccination is a promissing technique to induce cellular immune responses against an anitgen of interest. However clinical applications of DNA vaccination still suffer from poor immune responses. The aim of this project is to determine if the coexpression of a viral antigen and cell death modulating adaptor proteins can enhance the immune response as well as protection against a homologous viral challenge.