01 October 2017 → 30 September 2020
Research Foundation - Flanders (FWO)
Engineering and technology
- Other mechanical and manufacturing engineering
Necroptosis DR3-TL1A signaling Death receptor 3
Necroptosis is an inflammation-inducing process of induced necrosis. Death receptor 3 (DR3) is much less studied compared to other Death receptors. DR3-antibody inhibition in different mouse models of colitis leads to weakening of disease. This project aim to investigate whether DR3 is involved in Necrotizing enterocolitis (NEC) and whether DR3’s induction of necroptosis is a mechanism in its pathogenesis.