Project

Identification and characterization of new DAMPs during immunogenic apoptosis

Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
cell death cancer therapy ER stress inflammation
 
Project description

Therapeutic induction of ER stress in cancer cells by hypericin-based photodynamic therapy induces immunogenicity. This immunogenicity is in part characterized by emission of damage-associated molecular patterns (DAMPs). The aim is to identify and characterize new DAMPs, which are important for immunogenicity and to determine how they modulate different biological processes, such as anti-cancer responses, regeneration and tumor metastasis.