Research Explorer

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Researcher

Peter Vandenabeele

533 Results

2022

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannMaude JansGillian BlanckeFilip Van NieuwerburghLars VereeckeGeert van LooWim DeclercqPeter VandenabeeleJonathan Maelfait

A1 Journal Article in NATURE

Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer

Teodora-Eugenia OlteanLien LippensKelly LemeireCaroline De TenderHannelore DenysKatrien VandecasteelePeter VandenabeeleSandy Adjemian Catani

A1 Journal Article in FRONTIERS IN ONCOLOGY

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpGeert van LooPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz WiernickiSophia MaschalidiSandy Adjemian CataniTom Vanden BergheKodi RavichandranPeter Vandenabeele

A1 Journal Article in NATURE COMMUNICATIONS

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTatyana DivertRia RoelandtPeter TougaardTom Vanden BergheMarie JoossensGeert BerxNozomi TakahashiPeter Vandenabeele

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the role of MLKL and EVs in cell-cell communication during necroptosis

Benjamin CappePeter VandenabeeleFranck Riquet

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines

Behrouz HassanniaBartosz WiernickiPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in MOLECULES

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonCaroline De TenderStephan StremerschKoen RaemdonckWim DeclercqFranck RiquetKevin BraeckmansPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan MaelfaitNozomi TakahashiXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Spectrally Tunable Förster Resonance Energy Transfer-Based Biosensors Using Organic Dye Grafting

Marco Dalla VecchiaBenjamin CappePeter VandenabeeleFranck Riquet

U Journal Article in ACS SENSORS

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanBartosz WiernickiSze Men ChoiRia RoelandtWannes WeytsJelle HuysentruytBehrouz HassanniaEvelyne MeyerRuth SeurinckYvan SaeysAn VermeulenPeter VandenabeeleEric HosteTom Vanden Berghe

A1 Journal Article in NATURE COMMUNICATIONS

Viral RHIM proteins antagonise necroptosis by preventing ZBP1-induced RIPK1/RIPK3 amyloid formation in human cells

Josephine NemegeerLeslie NaesensSimon VerdonckEvelien DierickKatrien StaesPeter VandenabeeleJonathan Maelfait

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY

2021

A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency

Sandy Adjemian CataniPeter Vandenabeele

A1 Journal Article in CANCER DISCOVERY

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Richard de ReuverEvelien DierickBartosz WiernickiKatrien StaesLeen SeysEllen De MeesterTuur MuyldermansAlexander BotzkiBart LambrechtFilip Van NieuwerburghPeter VandenabeeleJonathan Maelfait

A1 Journal Article in CELL REPORTS

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleYves DondelingerMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

François SipieterBenjamin CappeElke De SchutterJolien BridelancePaco HulpiauWim DeclercqPeter VandenabeeleFranck Riquet

A1 Journal Article in ISCIENCE

Elucidation of the role of GSDME during apoptosis-driven secondary necrosis

Elke De SchutterPeter VandenabeeleFranck Riquet

GSDME and its role in cancer : from behind the scenes to the front of the stage

Elke De SchutterPeter Vandenabeele

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice

Peter Vandenabeele

A1 Journal Article in ATHEROSCLEROSIS

MLKL in cancer : more than a necroptosis regulator

Sofie MartensJolien BridelanceRia RoelandtPeter VandenabeeleNozomi Takahashi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Microbes exploit death-induced nutrient release by gut epithelial cells

Christopher AndersonLaura KarvelyteTania Love AaesIrina LambertzParul MehrotraAmanda GonçalvesKelly LemeireGillian BlanckeVanessa AndriesFarzaneh GhazaviArne MartensGeert van LooLars VereeckePeter VandenabeeleKodi Ravichandran

A1 Journal Article in NATURE

Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD

Hannelore Van EeckhoutteCaitlin GillisFien VerhammePeter VandenabeeleTom Vanden BergheGuy BrusselleKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Patients with COVID-19 : in the dark-NETs of neutrophils

Christian MaueröderPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Plasma membrane permeabilization following cell death : many ways to dye!

Elke De SchutterBenjamin CappeBartosz WiernickiPeter VandenabeeleFranck Riquet

A1 Journal Article in CELL DEATH DISCOVERY

Punching holes in cellular membranes : biology and evolution of gasdermins

Elke De SchutterRia RoelandtFranck RiquetAndy WullaertPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

François SipieterBenjamin CappePeter VandenabeeleFranck Riquet

A1 Journal Article in NATURE CELL BIOLOGY

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Peter Vandenabeele

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Targeting ferroptosis protects against multiorgan dysfunction and death

Tom Vanden BergheSamya Van CoillieBartosz WiernickiEmily Van SanSze Men ChoiRia RoelandtWannes WeytsJelle HuysentruytEvelyne MeyerRuth SeurinckYvan SaeysAn VermeulenPeter VandenabeeleEric Hoste

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

Tania Love AaesPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The role of lipid peroxidation in cell death and adaptive immune system regulation

Bartosz WiernickiPeter VandenabeeleKodi RavichandranTom Vanden Berghe

Therapeutic targeting of ferroptosis in experimental models of acute organ injury

Samya Van CoilliePeter VandenabeeleTom Vanden Berghe

Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy

Teodora-Eugenia OlteanPeter VandenabeeleJonathan Maelfait

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Teodora-Eugenia OlteanEmily Van SanTatyana DivertTom Vanden BergheXavier SaelensJonathan MaelfaitPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells

Jordy De ConinckGeert BerxPeter Vandenabeele

A1 Journal Article in SCIENCE IMMUNOLOGY

2020

An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Peter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Stephanie KourulaTom Vanden BerghePeter Vandenabeele

A1 Journal Article in NATURE MEDICINE

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Sandy Adjemian CataniPeter Vandenabeele

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Bartosz WiernickiHanne DuboisBehrouz HassanniaPeter VandenabeeleAndy WullaertTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation

Peter Vandenabeele

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu BertrandWim DeclercqGeert BerxDmitri KryskoSandy Adjemian CataniPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibitors targeting RIPK1/RIPK3 : old and new drugs

Sofie MartensWim DeclercqPeter Vandenabeele

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Sandy Adjemian CataniTeodora-Eugenia OlteanSofie MartensBartosz WiernickiVera GoossensTom Vanden BergheBenjamin CappeMaria LadikFranck RiquetLiesbeth HeyndrickxJolien BridelanceMarnik VuylstekeKatrien VandecasteelePeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauSavvas SavvidesSarah De GraeveGabriële HoltappelsNatalie De RuyckWim DeclercqPeter VandenabeeleDmitri KryskoClaus BachertOlga Krysko

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients

Björn De SamberTom Vanden BergheEline MeulJoél SmetBoel De PaepeRudy Van CosterPeter VandenabeeleLaszlo Vincze

A1 Journal Article in JOURNAL OF SYNCHROTRON RADIATION

Necroptosis in immuno-oncology and cancer immunotherapy

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELLS

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Michael DevosGiel TangheBarbara GilbertEvelien DierickJosephine NemegeerRichard de ReuverSylvie LefebvrePeter VandenabeeleWim DeclercqJonathan Maelfait

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice

Peter TougaardPeter Vandenabeele

A1 Journal Article in INTERNATIONAL JOURNAL OF OBESITY

Vitamin C controls neuronal necroptosis under oxidative stress

Peter Vandenabeele

A1 Journal Article in REDOX BIOLOGY

Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug

Behrouz HassanniaPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2019

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosArne MartensKarolina SlowickaWim DeclercqPeter VandenabeeleGeert van LooMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

Katharina D'HerdePeter Vandenabeele

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Comparative study of the differential cell death protecting effect of various ROS scavengers

Peter Vandenabeele

A1 Journal Article in BIOLOGICAL CHEMISTRY

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin BraeckmansXavier Saelens

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of receptor interacting protein kinase-3 and mixed lineage kinase domain-like protein in patients with COPD

Fien VerhammeHannelore Van EeckhoutteGuy BrussellePeter VandenabeeleTom Vanden BergheKen Bracke

Intersections between regulated cell death and autophagy

Peter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

Michael DevosBarbara GilbertPeter TougaardClaus BachertPeter VandenabeeleGeert van LooWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Necroptotic proteins in diseases : targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Sofie MartensPeter VandenabeeleNozomi TakahashiVera Goossens

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemDiego Rojas RiveraRia RoelandtSavvas SavvidesPeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE COMMUNICATIONS

Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-κB

Jelle HuysentruytTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in IMMUNITY

Targeting ferroptosis to iron out cancer

Behrouz HassanniaPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CANCER CELL

The molecular machinery of regulated cell death

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van MoorleghemSofie De PrijckNozomi TakahashiPeter VandenabeeleGeert van LooBart LambrechtSophie Janssens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps

Danielle ClancyChristian MaueröderPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Walter Fiers (1931-2019) : obituary

Wim DeclercqPeter VandenabeeleXavier Saelens

2018

Activation of Cx43 hemichannels by TNFα in HeLa cells stably overexpressing Cx43 and in the endothelial cell line EA.hy926

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleLuc Leybaert

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacy

Samya Van CoillieEline MeulPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van WyngeneRiet De RyckeNozomi TakahashiPeter VandenabeeleFrancis ImpensRudi BeyaertKarolien De BosscherRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation

Corinne UrwylerGiel TangheKirsten LeursBarbara GilbertRiet De RyckeMichiel De BruyneSaskia LippensSona BartunkovaPhilippe De GrootePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

MLKL reveals its friendly face : a role in nerve regeneration

Peter VandenabeeleWim DeclercqRia RoelandtTom Vanden Berghe

Editorial material

Macrophages regulate the clearance of living cells by calreticulin

Dmitri KryskoKodi RavichandranPeter Vandenabeele

Editorial material

Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018

Mathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis

Yann EstornesYves DondelingerKathrin WeberInge BruggemanPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiSimon Van HerckSze Men ChoiEline MeulKaren HeyninckDmitri KryskoBruno De GeestWim Vanden BerghePeter VandenabeeleTom Vanden Berghe

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

Björn De SamberEline MeulBrecht LaforceBoel De PaepeJoél SmetMichiel De BruyneRiet De RyckeRudy Van CosterPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in PLOS ONE

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS

Tinneke DelvaeyeKelly LemeireAmanda GonçalvesElke DecrockLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Kathrin WeberRia RoelandtInge BruggemanYann EstornesPeter Vandenabeele

A1 Journal Article in COMMUNICATIONS BIOLOGY

RIPK1-dependent cell death : a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie MartensVera GoossensMarnik VuylstekeNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization

Giel TangheCorinne UrwylerPhilippe De GrootePieter-Jan De BockKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda GonçalvesRudi BeyaertWim DeclercqPeter VandenabeeleDmitri KryskoClaus BachertOlga Krysko

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The pathological role of Cx43 and MLKL in TNF-induced systemic inflammatory response syndrome

Tinneke DelvaeyePeter VandenabeeleLuc LeybaertDmitri Krysko

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht CannoodtWouter SaelensBavo VannesteWendy ToussaintPieter De BleserNozomi TakahashiPeter VandenabeeleBart LambrechtGeert BerxYvan SaeysMartin Guilliams

A1 Journal Article in IMMUNITY

Therapeutic targeting of connexin channels : new views and challenges

Tinneke DelvaeyePeter VandenabeeleLuc LeybaertDmitri Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Tozasertib analogues as inhibitors of necroptotic cell death

Sofie MartensTatyana DivertWim NerinckxNozomi TakahashiVera GoossensPeter Vandenabeele

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2

Tom Vanden BergheSze Men ChoiSamya Van CoilliePeter Vandenabeele

A1 Journal Article in MOLECULAR CELL

2017

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

Fabienne Le CannPeter Vandenabeele

A1 Journal Article in SCIENTIFIC REPORTS

Caractérisation de nouveaux inhibiteurs de la kinase RIPK1 et de la nécroptose

Fabienne Le CannPeter Vandenabeele

Development of biosensing systems to monitor necroptosis

Maria LadikPeter VandenabeeleFranck Riquet

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedJo LambertLouis LibbrechtJody HaighGeert BerxSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heme oxygenase activity and heme binding in a neonatal mouse model

Stephanie KourulaPeter Vandenabeele

A1 Journal Article in NEONATOLOGY

How do we fit ferroptosis in the family of regulated cell death?

Peter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease

Elodie KipTom Vanden BerghePeter VandenabeeleRudi BeyaertSteven Van Gucht

A1 Journal Article in CELL DEATH DISCOVERY

Initiation and execution mechanisms of necroptosis : an overview

Sasker GrootjansTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ionizing radiation-induced cell death

Sandy Adjemian CataniKatrien VandecasteeleSofie MartensBartosz WiernickiTania Love AaesDmitri KryskoPeter Vandenabeele

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

Yves DondelingerTom DelangheDiego Rojas RiveraDario PriemTinneke DelvaeyeInge BruggemanFranky Van HerreweghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE CELL BIOLOGY

Modulation of Cx43 hemichannels by TNFα in HeLa cells overexpressing Cx43

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleDmitri KryskoLuc Leybaert

Necroptosis : (last) message in a bubble

Peter VandenabeeleFranck RiquetBenjamin Cappe

Editorial material

Necroptotic cell death in anti-cancer therapy

Olga KryskoTania Love AaesKatharina D'HerdeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNOLOGICAL REVIEWS

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in JOURNAL OF HEPATOLOGY

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in SCIENTIFIC REPORTS

Role of necroptotic cancer cells in anti-cancer immunity

Dmitri KryskoTania Love AaesPeter Vandenabeele

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis

Peter Vandenabeele

A1 Journal Article in FEBS JOURNAL

Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells

Sofie MartensPeter Vandenabeele

A1 Journal Article in ONCOTARGET

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie MartensVera GoossensNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Study of the functions of RIPK4 in epidermal development and signal transduction

Corinne UrwylerWim DeclercqPeter Vandenabeele

The impact of cell death modalities on the immunogenicity of cancer cells

Tania Love AaesPeter VandenabeeleDmitri Krysko

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

Sasker GrootjansPeter Vandenabeele

A1 Journal Article in ONCOGENE

When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas RiveraTinneke DelvaeyeRia RoelandtWim NerinckxPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter VandenabeeleTom Vanden Berghe

A1 Journal Article in NATURE PROTOCOLS

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress

Miguel AguiletaDiego Rojas RiveraVera GoossensYann EstornesGert Van IsterdaelPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

An evolutionary perspective on the necroptotic pathway

Yves DondelingerPaco HulpiauYvan SaeysMathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

An outline of necrosome triggers

Tom Vanden BergheBehrouz HassanniaPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo

Peter VandenabeeleKodi Ravichandran

A1 Journal Article in IMMUNITY

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

Yves DondelingerPeter Vandenabeele

A1 Journal Article in NATURE CELL BIOLOGY

Characterization of new proteins involved in apoptosis regulation

Miguel AguiletaMathieu BertrandPeter Vandenabeele

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DAMP-induced allograft and tumor rejection : the circle is closing

Peter VandenabeeleTom Vanden Berghe

A1 Journal Article in AMERICAN JOURNAL OF TRANSPLANTATION

Extracellular ATP and P₂X₇ receptor exert context-specific immunogenic effects after immunogenic cancer cell death

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Ferroptosis : triggers, inhibitors and therapeutic potential in neuroblastoma

Behrouz HassanniaPeter VandenabeeleWim Vanden BergheTom Vanden Berghe

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

Philippe De GrooteSasker GrootjansSaskia LippensChantal EichpergerKirsten LeursIrene KahrGiel TangheInge BruggemanWouter De SchamphelaireCorinne UrwylerPeter VandenabeeleJurgen HaustraeteWim Declercq

A1 Journal Article in BIOTECHNIQUES

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Sasker GrootjansPeter Vandenabeele

A1 Journal Article in BLOOD

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Peter Vandenabeele

A1 Journal Article in AUTOPHAGY

Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design

Debby LaukensBrigitta BrinkmanMartine De VosPeter Vandenabeele

A1 Journal Article in FEMS MICROBIOLOGY REVIEWS

Identification of potential receptor interacting protein kinase 1 substrates during necroptosis

Sasker GrootjansPeter Vandenabeele

Immunogenic apoptotic cell death and anticancer immunity

Peter VandenabeeleKatrien VandecasteeleClaus BachertOlga KryskoDmitri Krysko

A1 Journal Article in Advances in Experimental Medicine and Biology

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

Nozomi TakahashiPeter Vandenabeele

A1 Journal Article in ATHEROSCLEROSIS

Necroptosis: a novel cell death modality and its potential relevance for critical care medicine

Peter VandenabeeleDmitri Krysko

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel ferroptosis inhibitors with improved potency and ADME properties

Tom Vanden BergheBehrouz HassanniaPeter Vandenabeele

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Regulated necrosis: disease relevance and therapeutic opportunities

Peter Vandenabeele

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Regulation of RIPK1's cell death function by phosphorylation

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Editorial material

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Peter Vandenabeele

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate

Mathieu BertrandNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL REPORTS

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

Peter Vandenabeele

A1 Journal Article in ONCOTARGET

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De GrooteLuc LeybaertJohan GrootenMathieu BertrandGeert BerxWim DeclercqPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL REPORTS

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De RyckeChris GuerinGeert BerxPeter VandenabeeleSaskia LippensKris VleminckxWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh Nithyananda BabuGeorges LeclercqVera GoossensQuinten RemijsenPeter VandenabeeleRomain Lefebvre

A1 Journal Article in TOXICOLOGY AND APPLIED PHARMACOLOGY

Development and validation of kinase activity reporters for the dynamic study of cell response modalities by microscopy

François SipieterFranck RiquetPeter Vandenabeele

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Mathieu BertrandKodi RavichandranTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Dinesh Nithyananda BabuGeorges LeclercqVera GoossensTom Vanden BergheEvelien Van HammePeter VandenabeeleRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

Molecular and translational classifications of DAMPs in immunogenic cell death

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

Tom Vanden BergheMathieu BertrandPeter Vandenabeele

A2 Journal Article in MOLECULAR AND CELLULAR ONCOLOGY

NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling

Yves DondelingerSandrine JouanTatyana DivertPeter VandenabeeleMathieu Bertrand

A1 Journal Article in MOLECULAR CELL

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

Mathieu BertrandPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necroptosis and its role in inflammation

Peter Vandenabeele

A1 Journal Article in NATURE

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR HISTOLOGY

Novel reporter for faithful monitoring of ERK2 dynamics in living cells and model organisms

François SipieterBenjamin CappePeter VandenabeeleFranck Riquet

A1 Journal Article in PLOS ONE

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemInge BruggemanTatyana DivertSze Men ChoiMarnik VuylstekeClaude LibertPeter Vandenabeele

A1 Journal Article in IMMUNITY

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in ONCOTARGET

Unraveling the molecular mechanisms of RIPK1-mediated cell death

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Wavelet modeling and prediction of the stability of states: the Roman Empire and the European Union

Dmitri KryskoHendrik VosPeter Vandenabeele

A1 Journal Article in COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION

2014

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Caspase-3 and RasGAP: a stress-sensing survival/demise switch

Mathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Consensus guidelines for the detection of immunogenic cell death

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in ONCOIMMUNOLOGY

DAMPs activating innate and adaptive immune responses in COPD

Peter VandenabeeleDmitri Krysko

A1 Journal Article in MUCOSAL IMMUNOLOGY

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in AUTOPHAGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu BertrandNozomi TakahashiTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Informaticawetenschappen in het leerplichtonderwijs

Frederik De LaenderLennart MartensPeter VandenabeeleFrancis wyffels

Is SIRT2 required for necroptosis?

Peter Vandenabeele

A1 Journal Article in NATURE

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberSavvas SavvidesMathieu BertrandPeter Vandenabeele

A1 Journal Article in CELL REPORTS

Methods to study and distinguish necroptosis

Sasker GrootjansVera GoossensPeter VandenabeeleTom Vanden Berghe

Bookchapter in Necrotic cell death

Necroptosis, in vivo detection in experimental disease models

Sandrine JouanFranck RiquetLinde DuprezTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: a novel way of regulated necrosis with large pathophysiological implications

Peter VandenabeeleTom Vanden BergheNozomi Takahashi

Bookchapter in Pathobiology of human disease : a dynamic encyclopedia of disease mechanisms

Necrotic cell death

Non-apoptotic functions of caspase-7 during osteogenesis

Hervé LesotTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyerePeter VandenabeeleWim Van Den BroeckNiek SandersEvelyne Meyer

A1 Journal Article in PLOS ONE

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonPeter VandenabeeleWim Van Den BroeckNiek SandersEvelyne Meyer

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie KourulaVera GoossensSylvie LefebvreWim DeclercqGeert van LooPeter Vandenabeele

A1 Journal Article in NATURE

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

Yann EstornesMiguel AguiletaChristel DubuissonJulie De KeyserVera GoossensKristof KerssePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden BergheSandrine JouanPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shining light on cell death processes: a novel biosensor for necroptosis, a newly described cell death program

François SipieterMaria LadikPeter VandenabeeleFranck Riquet

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsMarnik VuylstekeRia RoelandtElien Van WonterghemSze Men ChoiEvelyne MeyerWim DeclercqNozomi TakahashiAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synchronized renal tubular cell death involves ferroptosis

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter VandenabeeleMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

The potential role of necroptosis in diseases

Tom Vanden BergheNozomi TakahashiPeter Vandenabeele

Bookchapter in Necrotic cell death

The skin microbiome of caspase-14-deficient mice shows mild dysbiosis

Malgorzata KubicaBrigitta BrinkmanPeter VandenabeeleWim Declercq

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

2013

An inactivating caspase-11 passenger mutation muddles sepsis research

Tom Vanden BergheAlain GoethalsDieter DemonPieter BogaertAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Kristof KerssePeter Vandenabeele

Bookchapter in Handbook of proteolytic enzymes

Caspase-14 overexpression in hairless mice is not involved in utricle formation

Michael DevosPhilippe De GrooteBarbara GilbertInge BruggemanKirsten LeursSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Caspase-14-deficient mice are more prone to the development of parakeratosis

Esther HosteGeertrui DeneckerBarbara GilbertFilip Van NieuwerburghBob AsselberghRiet De RyckeDieter DeforcePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-3 and caspase-7

Tom Vanden BergheKristof KerssePeter Vandenabeele

Bookchapter in Handbook of proteolytic enzymes

Caspase-7 participates in differentiation of cells forming dental hard tissues

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in DEVELOPMENT GROWTH & DIFFERENTIATION

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture

Kristel DemeyereQuinten RemijsenDieter DemonKoen BreyneSofie NotebaertFilip BoyenPeter VandenabeeleEvelyne Meyer

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype

Brigitta BrinkmanAnne BeckerRene AyisehGeert HuysPeter Vandenabeele

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish Kumar GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

Brigitta BrinkmanPeter Vandenabeele

A1 Journal Article in GENOME BIOLOGY

Many faces of DAMPs in cancer therapy

Olga KryskoTania Love AaesClaus BachertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNITY

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

Peter VandenabeeleSasker GrootjansNico CallewaertNozomi Takahashi

Editorial material

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Yves DondelingerMiguel AguiletaVera GoossensChristel DubuissonSasker GrootjansPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

Peter VandenabeeleDmitri Krysko

A1 Journal Article in AUTOPHAGY

Role of cell death and caspases in intestinal inflammation

Rene AyisehPeter VandenabeeleBrigitta Brinkman

Sensing of apoptotic and necroptotic cell death by the innate immune system

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

Agnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxTania Love AaesTinneke DelvaeyeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling

Olga KryskoTania MaesMaud PlantingaGabriële HoltappelsRosina ImiruPeter VandenabeeleGuy JoosDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Benjamin VandendriesscheElke RoggeVera GoossensPeter VandenabeelePeter BrouckaertAnje Cauwels

A1 Journal Article in PLOS ONE

2012

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Dmitri KryskoAgnieszka KaczmarekPeter Vandenabeele

A1 Journal Article in EMBO JOURNAL

ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages

Dmitri KryskoAgnieszka KaczmarekPeter Vandenabeele

A1 Journal Article in PLOS ONE

Autophagy: for better or for worse

Ellen WirawanTom Vanden BergheSaskia LippensPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

Beclin 1 : a role in membrane dynamics and beyond

Ellen WirawanSaskia LippensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in AUTOPHAGY

Caspase-7 in molar tooth development

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in ARCHIVES OF ORAL BIOLOGY

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Stephanie VerschuereLiesbeth AllaisKen BrackeSaskia LippensRebecca De SmetPeter VandenabeeleGuy BrusselleClaude Cuvelier

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Contribution of ER stress to immunogenic cancer cell death

Dmitri KryskoPeter Vandenabeele

Bookchapter in Endoplasmic reticulum stress in health and disease

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike

Magdalena WejdaFrancis ImpensNozomi TakahashiPetra Van DammeKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress and inflammation

Agnieszka KaczmarekDmitri KryskoPeter Vandenabeele

Bookchapter in Endoplasmic reticulum stress in health and disease

ER stress-induced inflammation: does it aid or impede disease progression?

Agnieszka KaczmarekOlga KryskoPeter VandenabeeleDmitri Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke

Peter Vandenabeele

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis

Michael DevosEsther HosteBarbara GilbertSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

Peter Vandenabeele

A1 Journal Article in AUTOPHAGY

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunogenic cell death and DAMPs in cancer therapy

Dmitri KryskoAgnieszka KaczmarekOlga KryskoPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS CANCER

Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome

Peter Vandenabeele

A1 Journal Article in SCIENCE SIGNALING

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis

Linde DuprezMathieu BertrandTom Vanden BergheYves DondelingerNele FestjensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Francesca GrespiNozomi TakahashiPeter VandenabeeleGennaro Melino

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many stimuli pull the necrotic trigger, an overview

Nele VanlangenakkerTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Peter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxVera GoossensRia RoelandtFilip Van HauwermeirenClaude LibertWim DeclercqNico CallewaertPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

Ellen WirawanSaskia LippensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

Nele VanlangenakkerMathieu BertrandPeter Vandenabeele

A1 Journal Article in LEUKEMIA

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

Sasker GrootjansPeter VandenabeeleKatharina D'Herde

A1 Journal Article in ANTI-CANCER DRUGS

Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways

Agnieszka KaczmarekBrigitta BrinkmanLiesbeth HeyndrickxPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF PATHOLOGY

Study of RIPK4 function in skin homeostasis and disease

Philippe De GrooteWim DeclercqSaskia LippensPeter Vandenabeele

Study on the role of ΔNp63α and caspase-14 in skin homeostasis and pathology

Michael DevosWim DeclercqPeter Vandenabeele

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

Franky Van HerrewegheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

Marlies GallePieter BogaertMira HaegmanPeter VandenabeeleRudi Beyaert

A1 Journal Article in PLOS ONE

The emergence of phox-ER stress induced immunogenic apoptosis

Dmitri KryskoPeter Vandenabeele

Editorial material

The flick of a switch: which death program to choose?

Peter VandenabeeleGennaro Melino

Editorial material

The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

Mathieu BertrandPeter Vandenabeele

A1 Journal Article in BIOLOGY OF THE CELL

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoAgnieszka KaczmarekMélissa BolNan WangMarijke De BockElke De VuystPeter VandenabeeleLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010

Wim DeclercqPeter Vandenabeele

Editorial material

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter VandenabeeleDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

Calcium and connexin-based intercellular communication, a deadly catch?

Elke DecrockMélissa BolKatharina D'HerdePeter VandenabeeleDmitri KryskoLuc Leybaert

A1 Journal Article in CELL CALCIUM

Caspase deficiency alters the murine gut microbiome

Brigitta BrinkmanMalgorzata KubicaWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HosteMichael DevosGeertrui DeneckerBarbara GilbertSaskia LippensPhilippe De GrooteRia RoelandtPetra Van DammeKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

Bookchapter in Apoptosis : physiology and pathology

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

Ellen WirawanPeter Vandenabeele

A1 Journal Article in NEUROBIOLOGY OF DISEASE

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim DeclercqNozomi TakahashiPeter Vandenabeele

Editorial material

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Quinten RemijsenEllen WirawanSaskia LippensPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Effect of LPS, dsRNA or interferons on the phagocytosis of dying cells or mycobacteria by macrophages

Tom Vanden BergheDmitri KryskoPeter Vandenabeele

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

Dmitri KryskoOlga KryskoClaus BachertBart LambrechtPeter Vandenabeele

A1 Journal Article in TRENDS IN IMMUNOLOGY

Fine-tuning nucleophosmin in macrophage differentiation and activation

Tom Vanden BerghePeter Vandenabeele

A1 Journal Article in BLOOD

In vitro characterization of bovine neutrophil cell death following Escherichia coli phagocytosis

Sofie NotebaertKristel DemeyereDieter DemonFilip BoyenChris GuerinPeter VandenabeeleEvelyne Meyer

Inflammasome modulation and NF-κB activation by caspase-1-related CARD domains

Kristof KerssePeter VandenabeeleTom Vanden BergheMathieu Bertrand

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Kristof KersseMohamed LamkanfiMathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Jurg Tschopp-1951-2011-an immortal contribution Obituary

Saskia LippensPeter Vandenabeele

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter VandenabeeleRudi BeyaertWim DeclercqGeert van Loo

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

Peter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Molecular interplay between autophagy and apoptosis through caspase-mediated cleavage of Beclin-1

Ellen WirawanPeter VandenabeeleSaskia Lippens

NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation

Sharen ProvoostTania MaesNele PauwelsTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosKurt Tournoy

A1 Journal Article in JOURNAL OF IMMUNOLOGY

NOD-like receptors and the innate immune system: coping with danger, damage and death

Kristof KersseMathieu BertrandMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Quinten RemijsenTom Vanden BergheEllen WirawanBob AsselberghEef ParthoensRiet De RyckeSamuel NoppenPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

Programmed necrosis : from molecules to health and disease

Tom Vanden BergheNele VanlangenakkerPeter Vandenabeele

A1 Journal Article in International Review of Cell and Molecular Biology

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

Ken BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of RIP1 in TNF-induced cell death in vitro and in vivo

Linde DuprezPeter VandenabeeleNozomi Takahashi

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Bram LaukensNele VanlangenakkerMathieu BertrandPeter Vandenabeele

A1 Journal Article in NEOPLASIA

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxPieter BogaertAnje CauwelsNozomi TakahashiClaus BachertPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Nele VanlangenakkerMathieu BertrandPieter BogaertPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

The Ripoptosome: death decision in the Cytosol

Mathieu BertrandPeter Vandenabeele

Editorial material

The death-fold superfamily of homotypic interaction motifs

Kristof KersseJelle VerspurtenTom Vanden BerghePeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

The in vivo role of executioner caspase-3 and -7 in the Escherichia coli-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

Unraveling TNF-induced necrotic signaling pathways using RNA interference and live-cell imaging

Nele VanlangenakkerPeter VandenabeeleTom Vanden Berghe

Workshop summary: cell death mechanisms controlled by the TNF family

Peter Vandenabeele

A1 Journal Article in Advances in Experimental Medicine and Biology

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Nele VanlangenakkerTom Vanden BerghePieter BogaertBram LaukensPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim DeclercqTom Vanden BergheSaskia LippensPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

Dmitri KryskoPeter Vandenabeele

Editorial material

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

Araceli Diez FraileTom Vanden BergheMarc EspeelPeter VandenabeeleKatharina D'Herde

A1 Journal Article in ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY

Hydroxylase inhibition abrogates TNF-α-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersKim OlievierSara BogaertBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

Peter VandenabeeleDmitri Krysko

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

Olga KryskoPeter VandenabeeleDmitri KryskoClaus Bachert

A1 Journal Article in APOPTOSIS

MYD88, TLR-2, TLR-9 and TNFR1-dependent signaling is essential for the sterile inflammatory response triggered by doxorubicin

Dmitri KryskoAgnieszka KaczmarekOlga KryskoPieter BogaertPeter Vandenabeele

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter VandenabeeleTom Vanden Berghe

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Tom Vanden BergheNele VanlangenakkerEef ParthoensMichael DevosNele FestjensChris GuerinWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Oxygen sensor inhibition attenuates TNF-α induced intestinal epithelial damage by hypoxia inducible factor (HIF) 1-dependent repression of fas-associated death domain protein (Fadd)

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

RIP1's function in NF-kappa B activation: from master actor to onlooker

Mathieu BertrandPeter Vandenabeele

Editorial material

Role of caspase-7 during early involution of the Escherichia coli- or the Staphylococcus aureus-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

Study of the role of caspase-14 in epidermal cornification

Esther HosteWim DeclercqPeter Vandenabeele

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Peter VandenabeeleWim DeclercqFranky Van HerrewegheTom Vanden Berghe

A1 Journal Article in SCIENCE SIGNALING

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

Franky Van HerrewegheNele FestjensWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2009

Caspase substrates: easily caught in deep waters?

Dieter DemonPetra Van DammeTom Vanden BergheJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

A1 Journal Article in APOPTOSIS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Peter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Connexin-related signaling in cell death: to live or let die?

Elke DecrockElke De VuystDmitri KryskoKatharina D'HerdePeter VandenabeeleVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Death receptor-induced necroptosis

Wim DeclercqFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Encyclopedia of life sciences

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

Jean-Christophe MarinePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt

Quinten RemijsenTom Vanden BergheEef ParthoensBob AsselberghPeter Vandenabeele

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Major cell death pathways at a glance

Linde DuprezEllen WirawanTom Vanden BerghePeter Vandenabeele

A1 Journal Article in MICROBES AND INFECTION

Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates

Freddy HaesebrouckKatharina D'HerdeDmitri KryskoHerman FavoreelPeter VandenabeeleRichard DucatelleAnnemie Decostere

A1 Journal Article in JOURNAL OF MORPHOLOGY

Molecular pathways of different types of cell death: many roads to death

Dmitri KryskoAgnieszka KaczmarekPeter Vandenabeele

Bookchapter in Phagocytosis of dying cells: from molecular mechanisms to human diseases

Necrosis: molecular mechanisms and physiological roles

Linde DuprezNele VanlangenakkerNele FestjensFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Essentials of apoptosis : a guide for basic and clinical research

Phagocytosis of dying cells: from molecular mechanisms to human diseases

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

Dieter DemonPetra Van DammeTom Vanden BergheAnnelies DeceuninckJoost Van DurmeJelle VerspurtenKenny HelsensFrancis ImpensMagdalena WejdaAnnemieke MadderJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

RIP Kinases at the Crossroads of Cell Death and Survival

Wim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL

Reconstitution of protection against Aspergillus infection in chronic granulomatous disease (CGD)

Quinten RemijsenPeter Vandenabeele

A1 Journal Article in BLOOD

SitePredicting the cleavage of proteinase substrates

Jelle VerspurtenKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Kristof KerssePeter Vandenabeele

A1 Journal Article in IMMUNITY

The emerging roles of serine protease cascades in the epidermis

Petra OvaereSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

Acute modulations in permeability barrier function regulate epidermal cornification - Role of caspase-14 and the protease activated receptor type 2

Wim DeclercqPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Apoptosis and necrosis: Detection, discrimination and phagocytosis

Dmitri KryskoTom Vanden BergheKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS

Apoptosome and caspase activation

Wim DeclercqPeter Vandenabeele

Bookchapter in Wiley Encyclopedia of Chemical Biology

Caspase-14 reveals its secrets

Geertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Kristof KersseWim DeclercqPeter Vandenabeele

Bookchapter in Encyclopedia of molecular pharmacology

Creation and x-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

Peter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

From regulation of dying cell engulfment to development of anti-cancer therapy

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

In vivo imaging of NF-kappa B activity during Escherichia coli-induced mammary gland infection

Peter VandenabeeleEvelyne Meyer

A1 Journal Article in CELLULAR MICROBIOLOGY

Inflammatory mediators in Escherichia coli-induced mastitis in mice

Dieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Life and death of female gametes during oogenesis and folliculogenesis

Dmitri KryskoAraceli Diez FraileGodelieve CrielPeter VandenabeeleKatharina D'Herde

A1 Journal Article in Apoptosis

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

Dmitri KryskoTom Vanden BergheEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS IN ENZYMOLOGY

Molecular mechanisms and pathophysiology of necrotic cell death

Nele VanlangenakkerTom Vanden BergheDmitri KryskoNele FestjensPeter Vandenabeele

A1 Journal Article in CURRENT MOLECULAR MEDICINE

Necrotic cell death and 'necrostatins': now we can control cellular explosion

Peter VandenabeeleWim DeclercqTom Vanden Berghe

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Role of Caspases in inflammation-driven diseases

Kristof KersseTom Vanden BergheSaskia LippensWim DeclercqPeter Vandenabeele

Bookchapter in Design of Caspase inhibitors as potential clinical agents

SELECTIVE STIMULATION OF EITHER TUMOR NECROSIS FACTOR RECEPTOR DIFFERENTIALLY INDUCES PAIN BEHAVIOR IN VIVO AND ECTOPIC ACTIVITY IN SENSORY NEURONS IN VITRO

Peter Vandenabeele

A1 Journal Article in NEUROSCIENCE

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

Mohamed LamkanfiPetra Van DammeTom Vanden BergheIsabel VanoverbergheJoël VandekerckhovePeter VandenabeeleKris Gevaert

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

The mitochondrial serine protease HtrA2/Omi: an overview

Lieselotte Vande WalleMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

Tom Vanden BergheDenis De KeukeleirePeter Vandenabeele

A1 Journal Article in PHYTOTHERAPY RESEARCH

2007

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Kristof KersseTom Vanden BergheMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Are metacaspases caspases?

Dominique VercammenWim DeclercqPeter VandenabeeleFrank Van Breusegem

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Caspase-14 protects against epidermal UVB photo-damage and water loss

Esther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in NATURE CELL BIOLOGY

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

Lieselotte Vande WalleXavier SaelensPeter Vandenabeele

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Caspases in cell survival, proliferation and differentiation

Mohamed LamkanfiNele FestjensWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Cell death types at a glance

Dmitri KryskoPeter VandenabeeleKatharina D'Herde

Bookchapter in Cell Apoptosis Research Advances

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs (Poster by O. Thomas)

Olivier ThomasEtienne SchachtPeter Vandenabeele

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs. Poster P49 by O. Thomas

Olivier ThomasEtienne SchachtPeter Vandenabeele

Generation of active recombinant human caspase-14

Philippe De GrootePetra OvaereEsther HosteSaskia LippensPeter VandenabeeleWim Declercq

Identification and characterization of filaggrin as a caspase-14 substrate

Esther HostePetra Van DammeJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Inflammatory caspases: targets for novel therapies

Sigrid CornelisKristof KersseNele FestjensMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

NADPH oxidases: new players in TNIF-induced necrotic cell death

Tom Vanden BergheWim DeclercqPeter Vandenabeele

Editorial material

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling

Mohamed LamkanfiPeter Vandenabeele

A1 Journal Article in IMMUNITY

Permeability barrier requirements regulate keratinocyte cornification: role of caspase 14 and the protease-activated receptor type 2

Wim DeclercqPeter Vandenabeele

Proteome-wide identification of HtrA2/Omi substrates

Lieselotte Vande WallePetra Van DammeMohamed LamkanfiXavier SaelensJoël VandekerckhoveKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

RIP1, a kinase on the crossroads of a cell's decision to live or die

Nele FestjensTom Vanden BergheSigrid CornelisPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

Mohamed LamkanfiPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation

Michaël KalaiNele FestjensAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2006

Apoptosis and necrosis, two fundamental alternatives

Peter Vandenabeele

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Peter Vandenabeele

A1 Journal Article in NATURE

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

Nele FestjensMichaël KalaiJoél SmetAnn MeeusRudy Van CosterXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspase inhibitors promote alternative cell death pathways

Peter VandenabeeleTom Vanden BergheNele Festjens

A4 Journal Article in Science Signal Transduction Knowledge Environment

Caspase-containing complexes in the regulation of cell death and inflammation

Nele FestjensSigrid CornelisMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOLOGICAL CHEMISTRY

Caspases leave the beaten track: caspase-mediated activation of NF-kappa B

Mohamed LamkanfiWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Cell death: initiation, propagation and clearance

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

Clearance of apoptotic and necrotic cells and its immunological consequences

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

A1 Journal Article in APOPTOSIS

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1 beta in salmonella-infected macrophages

Peter Vandenabeele

A1 Journal Article in NATURE IMMUNOLOGY

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs (Poster by O. Thomas)

Olivier ThomasEtienne SchachtPeter Vandenabeele

Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

Dmitri KryskoGeertrui DeneckerNele FestjensEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necrosis is associated with IL-6 production but apoptosis is not

Tom Vanden BergheMichaël KalaiGeertrui DeneckerAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

Nele FestjensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensKatharina D'HerdePeter VandenabeeleWim Declercq

Role of mitochondrial proteins in apoptosis.

Xavier SaelensNele FestjensLieselotte Vande WallePeter Vandenabeele

Bookchapter in Apoptosis and cancer therapy

The secret life of caspase-14

Geertrui DeneckerEsther HosteBarbara GilbertPetra OvaereKatharina D'HerdeSaskia LippensClaude LibertPeter VandenabeeleWim Declercq

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMarjan Van GurpGeertrui DeneckerMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1

Sigrid CornelisYanik BruynoogheGeert van LooXavier SaelensPeter VandenabeeleRudi Beyaert

A1 Journal Article in ONCOGENE

Apoptotic pathways and their regulation

Greet BrouckaertMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Apoptotic pathways as targets for novel therapies in cancer and other diseases

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

Peter Vandenabeele

Editorial material

Death penalty for keratinocytes: apoptosis versus cornification

Saskia LippensGeertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Fas induced necrosis.

Tom Vanden BergheNele FestjensMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Fas Signaling

Gap junctions and the propagation of cell survival and cell death signals

Dmitri KryskoLuc LeybaertPeter VandenabeeleKatharina D'Herde

A1 Journal Article in APOPTOSIS

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

Bart DepuydtGeert van LooPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL SCIENCE

Mitochondria: Breathe or die

Lieselotte Vande WalleNele FestjensXavier SaelensPeter Vandenabeele

Bookchapter in Apoptosis

Protein synthesis persists during necrotic cell death

Xavier SaelensNele FestjensEef ParthoensIsabel VanoverbergheMichaël KalaiPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand

Wim DeclercqPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera

Peter Vandenabeele

Editorial material

TNFR1-and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury

Peter Vandenabeele

A1 Journal Article in FASEB JOURNAL

2004

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

Saskia LippensWim DeclercqPeter Vandenabeele

A1 Journal Article in FASEB JOURNAL

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

Mohamed LamkanfiMichaël KalaiXavier SaelensWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-12: an overview

Mohamed LamkanfiMichaël KalaiPeter Vandenabeele

Editorial material

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMarjan Van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells

Peter Vandenabeele

A1 Journal Article in IMMUNOLOGY LETTERS

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

Xavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of protein-protein interactions in cell death signalling using the yeast two-hybrid system

Peter Vandenabeele

More than one way to die: methods to determine TNF-induced apoptosis and necrosis

Tom Vanden BergheGeertrui DeneckerGreet BrouckaertDmitri KryskoKatharina D'HerdePeter Vandenabeele

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

Greet BrouckaertMichaël KalaiDmitri KryskoXavier SaelensDominique VercammenMatladi NdlovuGuy HaegemanKatharina D'HerdePeter Vandenabeele

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1 beta

Peter SchotteGeertrui DeneckerAeke Van Den BroekePeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The use of proteomics in the study of cell death

Xavier SaelensKris GevaertJoël VandekerckhovePeter Vandenabeele

Bookchapter in When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

Toxic proteins released from mitochondria in cell death

Xavier SaelensNele FestjensLieselotte Vande WalleMarjan Van GurpGeert van LooPeter Vandenabeele

A1 Journal Article in ONCOGENE

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

Saskia LippensGeertrui DeneckerPeter VandenabeeleWim Declercq

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

Nele FestjensMarjan Van GurpGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in ACTA HAEMATOLOGICA

Caspase-1 and caspase-8 cleave and inactivate cellular parkin

Michaël KalaiPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies

Saskia LippensElke Van DammePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis

Xavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Tom Vanden BergheMichaël KalaiGeert van LooWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct regulation of cytosolic phospholipase A(2) phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL JOURNAL

Inhibition of nuclear factor-kappa B by a nitro-derivative of flurbiprofen: A possible mechanism for antiinflammatory and antiproliferative effect

Peter Vandenabeele

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

Peter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Peter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

Dmitri KryskoGreet BrouckaertMichaël KalaiPeter VandenabeeleKatharina D'Herde

A1 Journal Article in JOURNAL OF MORPHOLOGY

Mitochondrial intermembrane proteins in cell death

Marjan Van GurpNele FestjensGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappa B signaling

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases

Bert CallewaertGeorges De BruyneXavier SaelensPeter VandenabeeleMarcus MareelAncy Leroy

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The caspase family

Mohamed LamkanfiWim DeclercqBart DepuydtMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Caspases-Their Role in Cell Death and Cell Survival

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: Role in the Ca2+ sensitization of myosin light chain(20) phosphorylation

Peter Vandenabeele

A1 Journal Article in MOLECULAR PHARMACOLOGY

Type II autophagic cell death and death-associated protein kinases

Xavier SaelensPeter Vandenabeele

A2 Journal Article in Chemtracts. Biochemistry and molecular biology

Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2

Wim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

2002

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

Geert van LooHans DemolMarjan Van GurpPeter SchotteRudi BeyaertKris GevaertWim DeclercqJoël VandekerckhovePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

Mohamed LamkanfiWim DeclercqMichaël KalaiXavier SaelensPeter Vandenabeele

Editorial material

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Differential activation of nuclear factor-kappa B by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly.

Peter Vandenabeele

A1 Journal Article in FEBS LETTERS

Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas

Rudi BeyaertGeert van LooKaren HeyninckPeter Vandenabeele

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

Peter Vandenabeele

A1 Journal Article in NEUROPHARMACOLOGY

The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail.

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL JOURNAL

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

Geert van LooXavier SaelensMarjan Van GurpPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

Geert van LooMarjan Van GurpBart DepuydtKris GevaertJoël VandekerckhoveWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Michaël KalaiGeert van LooTom Vanden BergheAnn MeeusWilhelmina BurmXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL JOURNAL

2001

Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion.

Geertrui DeneckerPeter Vandenabeele

A1 Journal Article in TRANSPLANTATION

Apoptotic and necrotic cell death induced by death domain receptors.

Geertrui DeneckerWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooWalther FiersJohan GrootenWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.

Peter VandenabeeleGeertrui Denecker

A1 Journal Article in PHOTOCHEMISTRY AND PHOTOBIOLOGY

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation

Geert van LooPeter SchotteMarjan Van GurpHans DemolKris GevaertJoël VandekerckhoveWim DeclercqRudi BeyaertPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Heterotrimers formed by tumor necrosis factors of different species or muteins.

Paul AmelootWim DeclercqWalther FiersPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Paul AmelootWalther FiersPieter De BleserPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein.

Peter SchotteGeert van LooIsabelle CarpentierPeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse mammary gland involution is associated with cytochrome c release and caspase activation.

Wim DeclercqPeter Vandenabeele

A1 Journal Article in MECHANISMS OF DEVELOPMENT

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle.

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.

Peter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

The somatostatin analogue TT-232 induces apoptosis in A431 cells - Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.

Wim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Translation inhibition in apoptosis - Caspase-dependent PKR activation and eIF2-alpha phosphorylation.

Xavier SaelensMichaël KalaiPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Tumoricidal activity of monocyte-derived dendritic cells: Evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism.

Peter VandenabeeleFrans Willems

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAR pathways.

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL JOURNAL

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid.

Geertrui DeneckerWim DeclercqMarjan Van GurpPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

Geertrui DeneckerWim DeclercqPeter Vandenabeele

A1 Journal Article in CYTOKINE

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.

Saskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation.

Geertrui DeneckerPeter Vandenabeele

A1 Journal Article in CIRCULATION

How cells die counts - Reply.

Peter Vandenabeele

Editorial material

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooJohan GrootenWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Role of reactive oxygen species in tumor necrosis factor toxicity

Vera GoossensKatia VancompernolleWalther FiersPeter VandenabeeleJohan Grooten

Bookchapter in Antioxidant and redox regulation of genes

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeWalther FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

Wim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.

Wim DeclercqSaskia LippensPeter Vandenabeele

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3 - Consequences for altered intracellular distribution.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.

Marc Van De CraenPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.

Wim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins.

Wim Van MolleGeertrui DeneckerPeter BrouckaertPeter VandenabeeleClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27(Kip1) mediates its anti-apoptotic activity.

Marc Van De CraenPeter Vandenabeele

A1 Journal Article in ONCOGENE

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.

Rudi BeyaertPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

GAL4 is a substrate for caspases : implications for two-hybrid screening and other GAL4-based assays

Wim Van CriekingeSigrid CornelisMarc Van De CraenPeter VandenabeeleWalther FiersRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.

Marc Van De CraenWim DeclercqWim Van CriekingeWalther FiersPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.

Geertrui DeneckerPeter Vandenabeele

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Jerusalem of cytokines

Nozomi TakahashiPeter Vandenabeele

More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Walther FiersRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in ONCOGENE

Non-specific effects of methyl ketone peptide inhibitors of caspases.

Peter SchotteWim DeclercqSofie Van HuffelPeter VandenabeeleRudi Beyaert

A1 Journal Article in FEBS LETTERS

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.

Peter Vandenabeele

A1 Journal Article in FEBS LETTERS

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.

Marc Van De CraenGeert BerxWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Redox regulation of TNF signaling.

Vera GoossensKurt De VosMargino SteemansWalther FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in BIOFACTORS

The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.

Wim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The proteolytic procaspase activation network: an in vitro analysis.

Marc Van De CraenWim DeclercqWalther FiersPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.

Peter Vandenabeele

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1998

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

Margino SteemansVera GoossensMarc Van De CraenKatia VancompernolleKurt De VosPeter VandenabeeleJohan Grooten

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.

Katia VancompernolleGwenda PynaertMarc Van De CraenKurt De VosWalther FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in FEBS LETTERS

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalther FiersPeter VandenabeeleRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.

Wim DeclercqGeertrui DeneckerWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.

Dominique VercammenGreet BrouckaertGeertrui DeneckerMarc Van De CraenWim DeclercqWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis - Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.

Peter VandenabeeleWim Declercq

A1 Journal Article in FEBS LETTERS

Identification of a new caspase homologue: caspase-14.

Marc Van De CraenGeert van LooWim Van CriekingeWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Molecular cloning and identification of murine caspase-8.

Geert van LooWim DeclercqWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.

Dominique VercammenRudi BeyaertPeter Vandenabeele

A1 Journal Article in CYTOKINE

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenPeter VandenabeeleGuy HaegemanWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II

Paul AmelootPeter Vandenabeele

A1 Journal Article in BIOSCIENCE REPORTS

Use of the yeast three-hybrid system as a tool to study caspases.

Wim Van CriekingeMarjan Van GurpEls DecosterPeter SchotteMarc Van De CraenWalther FiersPeter VandenabeeleRudi Beyaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

1997

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.

Karen HeyninckWim Van CriekingePeter VandenabeeleWalther FiersRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bactericidal permeability-increasing protein release in whole blood ex vivo: Strong induction by lipopolysaccharide and tumor necrosis factor-alpha.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Cell death induction by receptors of the TNF family: Towards a molecular understanding.

Rudi BeyaertPeter VandenabeeleWalther Fiers

A1 Journal Article in FEBS LETTERS

Characterization of seven murine caspase family members

Peter VandenabeeleWim DeclercqGeert van LooPeter SchotteWim Van CriekingeRudi BeyaertWalther Fiers

A1 Journal Article in FEBS LETTERS

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.

Rudi BeyaertSigrid CornelisGeertrui DeneckerPeter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of caspase family members by granzyme B: A comparative study in vitro.

Wim DeclercqRudi BeyaertWalther FiersPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.

Peter VandenabeeleWalther FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenWim DeclercqRudi BeyaertWalther Fiers

A1 Journal Article in CYTOKINE

Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1.

Peter Vandenabeele

A1 Journal Article in IMMUNOLOGY

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

Dominique VercammenPeter VandenabeeleRudi BeyaertWim DeclercqWalther Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walther FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren HeyninckMarc Van De CraenPeter VandenabeeleWim Vanden BergheVeronique VandevoordeDominique Vercammen

Bookchapter in HIV and cytokines

1996

Functional characterization of the prodomain of interleukin-1 beta-converting enzyme.

Wim Van CriekingeRudi BeyaertPeter VandenabeelePeter SchotteWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia.

Peter VandenabeeleWalther Fiers

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.

Peter VandenabeeleNozomi TakahashiWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walther FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtVera GoossensJohan GrootenGuy HaegemanKaren HeyninckKatia VancompernolleWim Van CriekingePeter VandenabeeleVeronique VandevoordeDominique Vercammen

A1 Journal Article in JOURNAL OF INFLAMMATION

1995

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.

Peter VandenabeeleWim DeclercqRudi BeyaertWalther Fiers

A1 Journal Article in TRENDS IN CELL BIOLOGY

BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.

Peter VandenabeeleWim DeclercqJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalther Fiers

A2 Journal Article in J. Immunol.. 154, pp. 2904-2913

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.

Rudi BeyaertBart VanhaesebroeckWim DeclercqPeter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.

Peter VandenabeeleWim DeclercqJohan GrootenWalther Fiers

A1 Journal Article in CYTOKINE

Dimerization of chimeric erythropoietin 75 kDa tumour-necrosis-factor (TNF) receptors transduces TNF signals - Necessity for the 75 kDa TNF-receptor transmembrane domain.

Wim DeclercqPeter VandenabeeleWalther Fiers

A1 Journal Article in CYTOKINE

Generation and biological characterization of membrane-bound, uncleavable murine tumor-necrosis factor.

Els DecosterBart VanhaesebroeckPeter VandenabeeleJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Two tumour necrosis factor receptors : structure and function

Peter VandenabeeleWim DeclercqRudi BeyaertWalther Fiers

A2 Journal Article in TRENDS IN CELL BIOLOGY

1994

DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS.

Peter VandenabeeleJan TavernierWalther Fiers

A1 Journal Article in EMBO JOURNAL

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleRudi BeyaertWim DeclercqJohan GrootenWalther Fiers

A1 Journal Article in CIRCULATORY SHOCK

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.

Peter VandenabeeleJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

IFN-GAMMA PREVENTS TH2 CELL-MEDIATED PATHOLOGY AFTER NEONATAL INJECTION OF SEMIALLOGENIC SPLEEN-CELLS IN MICE.

Peter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTERLEUKIN-10 CONTROLS INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR PRODUCTION DURING EXPERIMENTAL ENDOTOXEMIA.

Peter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

In vivo immunosuppression induced by a weakly mitogenic antibody to mouse CD3: evidence that induction of long-lasting in vivo unresponsiveness requires TcR signaling

Peter Vandenabeele

A1 Journal Article in CELLULAR IMMUNOLOGY

Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal-antibody in mice by interleukin-10.

Peter VandenabeeleWalther Fiers

A1 Journal Article in TRANSPLANTATION

The protective role of interleukin-10 in endotoxin shock

Peter Vandenabeele

A2 Journal Article in Progress in clinical and biological research

1993

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR.

Peter VandenabeeleJan TavernierPeter BrouckaertWalther Fiers

A1 Journal Article in NATURE

INCREASED IL-6 PRODUCTION AND IL-6-MEDIATED IG SECRETION IN MURINE HOST-VS-GRAFT DISEASE.

Peter VandenabeeleJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTERLEUKIN-10 REDUCES THE RELEASE OF TUMOR-NECROSIS-FACTOR AND PREVENTS LETHALITY IN EXPERIMENTAL ENDOTOXEMIA.

Peter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckVera GoossensJohan GrootenGuy HaegemanClaude LibertNozomi TakahashiPeter VandenabeeleBart VanhaesebroeckXaveer Van OstadeFrans Van Roy

1992

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

Peter VandenabeeleWim DeclercqDominique VercammenMarc Van De CraenJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1991

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone

Peter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enzymatic degradation of tumor necrosis factor by activated human neutrophils: role of elastase

Peter Vandenabeele

A1 Journal Article in LIFE SCIENCES

Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome

Peter Vandenabeele

A1 Journal Article in TRANSPLANTATION

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

Peter VandenabeeleWalther Fiers

Editorial material

1990

Acute toxicity of anti-CD3 monoclonal antibody in mice : a model for OKT3 first dose reactions

Peter Vandenabeele

A1 Journal Article in TRANSPLANTATION PROCEEDINGS

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1

Peter VandenabeeleWim DeclercqClaude LibertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Hypothermia and hypoglycemia induced by anti-CD3 monoclonal antibody in mice : role of tumor necrosis factor

Peter VandenabeeleWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression

Peter VandenabeeleJohan GrootenWalther Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis

Peter VandenabeeleWalther Fiers

A1 Journal Article in NEPHRON

Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice

Peter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Response of murine cell lines to an IL-1/IL-2 induced factor in a rat mouse T hybridoma (PC60) : differential induction of cytokines by human IL-1α and IL-1β and partial amino acid sequence of rat GM-CSF

Peter VandenabeeleYves GuisezWim DeclercqGuy BauwJoël VandekerckhoveWalther Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

1988

Interleukin 1α acts as an autocrine growth factor for RPMI1788, an Epstein-Barr virus-transformed human B cell line

Peter VandenabeeleWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Plasmacytoma growth factor activity of murine granulocyte-macrophage colony-stimulating factor

Peter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1987

A T cell clone which responds to interkeukin 2 but not to interleukin 4

Peter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-β2, HPGF)

Peter VandenabeeleGuy HaegemanWalther Fiers

A1 Journal Article in EMBO JOURNAL

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walther FiersRudi BeyaertPeter BrouckaertGuy HaegemanJan TavernierPeter VandenabeeleFrans Van Roy

A1 Journal Article in IMMUNOLOGY LETTERS

1985

Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus cowan strain I activated human B-cells

Peter VandenabeeleWalther Fiers

A1 Journal Article in IMMUNOLOGY LETTERS