Research Explorer

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Researcher

Peter Vandenabeele

Publications & Research Data

Awards & Distinctions

566 Results

2026

Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis

Wei XieLaura WyckaertMike VadiBruno VerstraetenTatyana DivertJef HaerinckRiet De RyckeFemke BaekeMohamed LamkanfiGeert Berx et al.

A1 Journal Article in SCIENCE ADVANCES

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

Carlos Plaza-SirventHannah SturmMaximilian K. NockeFatemeh GhorbaniClara BessenMarina C. Greweling-PilsStefan FloessJana NiemzJelle HuysentruytPeter Tougaard et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2025

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

Development and validation of a high-throughput screening pipeline of compound libraries to target EMT

Sven JonckheereJoachim TaminauJamie AdamsJef HaerinckJordy De ConinckJeroen VerstappeKato De ClercqEvelien PeetersAlexander GheldofEva De Smedt et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne VerschuereSabah KasmiLutz NuhnSènan Mickaël D'AlmeidaQiwen ZhuZifu ZhongSandy Adjemian CataniBenoit LouageJana De VriezeHaijun Yu et al.

A1 Journal Article in RSC ADVANCES

For better or worse : the impact of necrotic cell death modalities

Peter VandenabeeleMarcus ConradAdam Wahida

Bookchapter in Apoptosis and other forms of cell death in the regulation of inflammation in health and disease

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice

Thomas PilotStéphanie SolierAntoine JalilCharlène MagnaniTom Vanden BerghePeter VandenabeeleDavid MassonEric SolaryCharles Thomas

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Regulation of interferon-mediated autoinflammation by RIPK1 and ADAR1

Simon VerdonckJonathan MaelfaitPeter Vandenabeele

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenTatyana DivertKayleigh FliesKelly LemeireNozomi TakahashiElke De BruynMarie Joossens et al.

A1 Journal Article in EMBO REPORTS

2024

A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs

Benjamin CappePeter VandenabeeleFranck Riquet

A1 Journal Article in FEBS JOURNAL

Ferroptosis in health and disease

Carsten BerndtHamed AlborziniaVera Skafar AmenScott AytonUladzimir BarayeuAlexander BarteltHülya BayirChristina M BebberKivanc BirsoyJan P Böttcher et al.

A1 Journal Article in REDOX BIOLOGY

Harnessing luciferase chemistry in regulated cell death modalities and autophagy : overview and perspectives

Saman HosseinkhaniMojdeh AmandadiParisa GhanavatianFateme ZareinFarangis AtaeiMaryam NikkhahPeter Vandenabeele

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury

Christopher AndersonLaura BoeckaertsPriscilla ChinJavier BurgoaWei XieAmanda GonçalvesGillian BlanckeSam BensonSebastian RogattiMariska S. Simpson et al.

A1 Journal Article in CELL HOST & MICROBE

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Teodora-Eugenia OlteanJonathan MaelfaitXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH DISCOVERY

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The thymus road to a T cell : migration, selection, and atrophy

Mario Ruiz PérezPeter VandenabeelePeter Tougaard

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Thymus development during acute inflammation

Mario Ruiz PérezPeter VandenabeelePeter Tougaard

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia Roelandt et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2023

Activation and viral escape of ZBP1-mediated host cell death

Josephine NemegeerJonathan MaelfaitPeter Vandenabeele

Apoptotic cell death in disease : current understanding of the NCCD 2023

Ilio VitaleFederico PietrocolaEmma GuilbaudStuart A AaronsonJohn M AbramsDieter AdamMassimiliano AgostiniPatrizia AgostinisEmad S AlnemriLucia Altucci et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues

Stéphanie SolierMichele MondiniLydia MezianiArnaud JacquelCatherine LacoutTom Vanden BergheYvon JuléJean-Claude MartinouGérard PierronJulie Rivière et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the role of RIPK1 in T cell homeostasis

Jelle HuysentruytPeter VandenabeelePeter Tougaard

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Emily Van SanAngela DebruyneGeraldine VeeckmansYulia Y. Y. TyurinaVladimir A. A. TyurinHao ZhengSze Men ChoiKoen AugustynsGeert van LooBernhard Michalke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Impact of EMT on regulated cell death and immune activation in colorectal cancer

Hanne VerschuerePeter VandenabeeleGeert Berx

Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells

Roberto Fernández-AcostaBehrouz HassanniaJurgen CaroenBartosz WiernickiDaniel Alvarez-AlminaqueBruno VerstraetenJohan Van der EyckenPeter VandenabeeleTom Vanden BergheGilberto L. Pardo-Andreu

A1 Journal Article in CELLS

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Peter VandenabeeleGeert BultynckSavvas Savvides

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis

Benjamin CappeMike VadiEliza SackLudivine WacheulBruno VerstraetenSara DufourJulien FranckWei XieFrancis ImpensAn Hendrix et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Therapeutic exploration of ferroptosis in multiple sclerosis

Emily Van SanTom Vanden BerghePeter Vandenabeele

Trial watch : chemotherapy-induced immunogenic cell death in oncology

Jenny SprootenRaquel S LaureanoIsaure VanmeerbeekJannes GovaertsStefan NaulaertsDaniel M BorrasLisa KingetJitka FucikovaRadek SpisekLenka Palova Jelinkova et al.

A1 Journal Article in ONCOIMMUNOLOGY

2022

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander Botzki et al.

A1 Journal Article in NATURE

Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer

Teodora-Eugenia OlteanLien LippensKelly LemeireCaroline De TenderMarnik VuylstekeHannelore DenysKatrien VandecasteelePeter VandenabeeleSandy Adjemian Catani

A1 Journal Article in FRONTIERS IN ONCOLOGY

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz WiernickiSophia MaschalidiJonathan PinneySandy Adjemian CataniTom Vanden BergheKodi RavichandranPeter Vandenabeele

A1 Journal Article in NATURE COMMUNICATIONS

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian Popper et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the role of MLKL and EVs in cell-cell communication during necroptosis

Benjamin CappePeter VandenabeeleFranck Riquet

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertMarnik VuylstekeGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines

Roberto Fernandez-AcostaClaudia Iriarte-MesaDaniel Alvarez-AlminaqueBehrouz HassanniaBartosz WiernickiAlicia M. Diaz-GarciaPeter VandenabeeleTom Vanden BergheGilberto L. Pardo Andreu

A1 Journal Article in MOLECULES

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonBenjamin PfeutyCaroline De TenderStephan StremerschKoen RaemdonckKen Op de BeeckWim DeclercqFranck RiquetKevin Braeckmans et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan Maelfait et al.

A1 Journal Article in CELL DEATH & DISEASE

Spectrally tunable Förster resonance energy transfer-based biosensors using organic dye grafting

Marco Dalla VecchiaAmandine Conte-DabanBenjamin CappeWim VandenbergPeter VandenabeeleFranck RiquetPeter Dedecker

A1 Journal Article in ACS SENSORS

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van CoillieEmily Van SanInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusSze Men ChoiRia RoelandtCatalina DumitrascuLudwig Lamberts et al.

A1 Journal Article in NATURE COMMUNICATIONS

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY

Viral RHIM proteins antagonise necroptosis by preventing ZBP1-induced RIPK1/RIPK3 amyloid formation in human cells

Josephine NemegeerLeslie NaesensSimon VerdonckEvelien DierickKatrien StaesPeter VandenabeeleJonathan Maelfait

2021

A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency

Julie Le NaourPeng LiuLiwei ZhaoSandy Adjemian CataniZsofia SztupinszkiJulien TaiebClaire MulotAymeric SilvinCharles-Antoine DutertreFlorent Ginhoux et al.

A1 Journal Article in CANCER DISCOVERY

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Richard de ReuverEvelien DierickBartosz WiernickiKatrien StaesLeen SeysEllen De MeesterTuur MuyldermansAlexander BotzkiBart LambrechtFilip Van Nieuwerburgh et al.

A1 Journal Article in CELL REPORTS

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

François SipieterBenjamin CappeAymeric LerayElke De SchutterJolien BridelancePaco HulpiauGuy Van CampWim DeclercqLaurent HeliotPierre Vincent et al.

A1 Journal Article in ISCIENCE

Elucidation of the role of GSDME during apoptosis-driven secondary necrosis

Elke De SchutterGuy Van CampPeter VandenabeeleFranck Riquet

GSDME and its role in cancer : from behind the scenes to the front of the stage

Elke De SchutterLieselot CroesJoe IbrahimPatrick PauwelsKen Op de BeeckPeter VandenabeeleGuy Van Camp

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice

Isabelle CoornaertPauline PuylaertGiullia MarcasolliMandy O. J. GrootaertPeter VandenabeeleGuido R. Y. De MeyerWim Martinet

A1 Journal Article in ATHEROSCLEROSIS

Microbes exploit death-induced nutrient release by gut epithelial cells

Christopher AndersonChristopher B. MedinaBrady J. BarronLaura KarvelyteTania Love AaesIrina LambertzJustin S. A. PerryParul MehrotraAmanda GonçalvesKelly Lemeire et al.

A1 Journal Article in NATURE

MLKL in cancer : more than a necroptosis regulator

Sofie MartensJolien BridelanceRia RoelandtPeter VandenabeeleNozomi Takahashi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD

Zhe LuHannelore Van EeckhoutteGang LiuPrema M NairBernadette JonesCaitlin GillisB. Christina NalkurthiFien VerhammeTamariche Buyle-HuybrechtPeter Vandenabeele et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Patients with COVID-19 : in the dark-NETs of neutrophils

Maximilian AckermannHans-Joachim AndersRostyslav BilyyGary L. BowlinChristoph DanielRebecca De LorenzoMikala EgebladTimo HenneckAndres HidalgoMarkus Hoffmann et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Plasma membrane permeabilization following cell death : many ways to dye!

Elke De SchutterBenjamin CappeBartosz WiernickiPeter VandenabeeleFranck Riquet

A1 Journal Article in CELL DEATH DISCOVERY

Punching holes in cellular membranes : biology and evolution of gasdermins

Elke De SchutterRia RoelandtFranck RiquetGuy Van CampAndy WullaertPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Bas PonsioenJasmin B. PostJulian R. Buissant des AmorieDimitrios LaskarisRavian L. van IneveldSimone KerstenAndrea BertottiFrancesco SassiFrançois SipieterBenjamin Cappe et al.

A1 Journal Article in NATURE CELL BIOLOGY

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Antonia Clarissa WehnIgor KhalinMarco DueringFarida HellalCarsten CulmseePeter VandenabeeleNikolaus PlesnilaNicole Angela Terpolilli

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Targeting ferroptosis protects against multiorgan dysfunction and death

Tom Vanden BergheSamya Van CoillieInes GoetschalckxBartosz WiernickiBanibrata MukhopadhyayWulf TonnusEmily Van SanSze Men ChoiRia RoelandtCatalina Dumitrascu et al.

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

Tania Love AaesPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The role of lipid peroxidation in cell death and adaptive immune system regulation

Bartosz WiernickiPeter VandenabeeleKodi RavichandranTom Vanden Berghe

Therapeutic targeting of ferroptosis in experimental models of acute organ injury

Samya Van CoilliePeter VandenabeeleTom Vanden Berghe

Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy

Teodora-Eugenia OlteanPeter VandenabeeleJonathan MaelfaitSandy Adjemian Catani

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Teodora-Eugenia OlteanEmily Van SanTatyana DivertTom Vanden BergheXavier SaelensJonathan MaelfaitNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells

Adam WahidaMadeleine MuellerAndreas HiergeistBastian PopperKatja SteigerCaterina BrancaMarkus TschurtschenthalerThomas EngleitnerSainitin DonakondaJordy De Coninck et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2020

An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpRosa Martin-PerezAnnalisa ZecchinPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Jinho SeoDaehyeon SeongYoung Woo NamChi Hyun HwangSeung Ri LeeChoong-Sil LeeYoung JinHan-Woong LeeDoo-Byoung OhPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula RobertiSatoru YonekuraConnie P. M. DuongMarion PicardGladys FerrereMaryam Tidjani AlouConrad RauberValerio IebbaChristian H. K. LehmannLukas Amon et al.

A1 Journal Article in NATURE MEDICINE

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo GalluzziIlio VitaleSarah WarrenSandy Adjemian CataniPatrizia AgostinisAitziber Buqué MartinezTimothy A ChanGeorge CoukosSandra DemariaEric Deutsch et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Bartosz WiernickiHanne DuboisYulia Y. TyurinaBehrouz HassanniaHulya BayirValerian E. KaganPeter VandenabeeleAndy WullaertTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation

Daehyeon SeongManhyung JeongJinho SeoJi-Yoon LeeChi Hyun HwangHo-Chul ShinJeong Yoon ShinYoung Woo NamJeong Yeon JoHaeseung Lee et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu Bertrand et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibitors targeting RIPK1/RIPK3 : old and new drugs

Sofie MartensSam HofmansWim DeclercqKoen AugustynsPeter Vandenabeele

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Sandy Adjemian CataniTeodora-Eugenia OlteanSofie MartensBartosz WiernickiVera GoossensTom Vanden BergheBenjamin CappeMaria LadikFranck RiquetLiesbeth Heyndrickx et al.

A1 Journal Article in CELL DEATH & DISEASE

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients

Björn De SamberTom Vanden BergheEline MeulStephen BautersMartin SeyrichJoél SmetBoel De PaepeJulio Cesar da SilvaSylvain BohicPeter Cloetens et al.

A1 Journal Article in JOURNAL OF SYNCHROTRON RADIATION

Necroptosis in immuno-oncology and cancer immunotherapy

Jenny SprootenPieter De WijngaertIsaure VanmeerbeekShaun MartinPeter VangheluweSusan SchlennerDmitri KryskoJan B. ParysGeert BultynckPeter Vandenabeele et al.

A1 Journal Article in CELLS

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Michael DevosGiel TangheBarbara GilbertEvelien DierickMaud VerheirstraetenJosephine NemegeerRichard de ReuverSylvie LefebvreJolien De MunckJan Rehwinkel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice

Peter TougaardLouise Otterstrom MartinsenDitte Olsen LuetzhoftHenrik Elvang JensenMette FlethojPeter VandenabeeleAnders Elm PedersenSoren SkovAxel Kornerup HansenCamilla Hartmann Friis Hansen

A1 Journal Article in INTERNATIONAL JOURNAL OF OBESITY

Vitamin C controls neuronal necroptosis under oxidative stress

Luciano FerradaMaria Jose BarahonaKatterine SalazarPeter VandenabeeleFrancisco Nualart

A1 Journal Article in REDOX BIOLOGY

Withaferin A : from ayurvedic folk medicine to preclinical anti-cancer drug

Behrouz HassanniaEmilie LogiePeter VandenabeeleTom Vanden BergheWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2019

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosSarah DruwéArne MartensKarolina SlowickaAdrian T TingManolis PasparakisWim DeclercqPeter VandenabeeleGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

R SabelAS FronzaLZB CarrenhoA MaesML BarrosLAE PolloMW BiavattiKatharina D'HerdePeter VandenabeeleMRO Kreuger

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy

Filipe ElvasTom Vanden BergheYves AdriaenssensPeter VandenabeeleKoen AugustynsSteven StaelensSigrid StroobantsPieter Van der VekenLeonie Wyffels

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Comparative study of the differential cell death protecting effect of various ROS scavengers

Nezka KavcicKatarina PeganPeter VandenabeeleBoris Turk

A1 Journal Article in BIOLOGICAL CHEMISTRY

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of receptor interacting protein kinase-3 and mixed lineage kinase domain-like protein in patients with COPD

Fien VerhammeHannelore Van EeckhoutteT Buyle-HuybrechtGuy BrussellePeter VandenabeeleTom Vanden BergheKen Bracke

Intersections between regulated cell death and autophagy

Francesco NapoletanoOlga BaronPeter VandenabeeleBertrand MollereauManolis Fanto

A1 Journal Article in TRENDS IN CELL BIOLOGY

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

Michael DevosDenis A MogilenkoSébastien FleuryBarbara GilbertCoralie BecquartSandrine QuemenerHélène DehondtPeter TougaardBart StaelsClaus Bachert et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Necroptotic proteins in diseases : targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Sofie MartensPeter VandenabeeleNozomi TakahashiVera Goossens

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-κB

Louise V WebbAlessandro BarbaruloJelle HuysentruytTom Vanden BergheNozomi TakahashiSteven LeyPeter VandenabeeleBenedict Seddon

A1 Journal Article in IMMUNITY

Targeting ferroptosis to iron out cancer

Behrouz HassanniaPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CANCER CELL

The molecular machinery of regulated cell death

Daolin TangRui KangTom Vanden BerghePeter VandenabeeleGuido Kroemer

A1 Journal Article in CELL RESEARCH

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

To NET or not to NET : current opinions and state of the science regarding the formation of neutrophil extracellular traps

Sebastian BoeltzPoorya AminiHans-Joachim AndersFelipe AndradeRostyslav BilyySimon ChatfieldIwona CichonDanielle ClancyJyaysi DesaiTetiana Dumych et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Walter Fiers (1931-2019) : obituary

Wim DeclercqPeter VandenabeeleXavier Saelens

2018

Activation of Cx43 hemichannels by TNFα in HeLa cells stably overexpressing Cx43 and in the endothelial cell line EA.hy926

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleLuc Leybaert

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacy

Lars DevisscherSamya Van CoillieSam HofmansDries Van RompaeyKenneth GoossensEline MeulLouis MaesHans De WinterPieter Van Der VekenPeter Vandenabeele et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation

Corinne UrwylerGiel TangheKirsten LeursBarbara GilbertRiet De RyckeMichiel De BruyneSaskia LippensSona BartunkovaPhilippe De GrooteCarien Niessen et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophages regulate the clearance of living cells by calreticulin

Dmitri KryskoKodi RavichandranPeter Vandenabeele

Editorial material

MLKL reveals its friendly face : a role in nerve regeneration

Peter VandenabeeleWim DeclercqRia RoelandtTom Vanden Berghe

Editorial material

Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo GalluzziIlio VitaleStuart A AaronsonJohn M AbramsDieter AdamPatrizia AgostinisEmad S AlnemriLucia AltucciIvano AmelioDavid W. Andrews et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis

Yann EstornesYves DondelingerKathrin WeberInge BruggemanAdam PeallMarion MacFarlaneSerge LebecquePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men Choi et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts

Björn De SamberEline MeulBrecht LaforceBoel De PaepeJoél SmetMichiel De BruyneRiet De RyckeSylvain BohicPeter CloetensRudy Van Coster et al.

A1 Journal Article in PLOS ONE

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS

Tinneke DelvaeyeLeonie wyffelsSteven DeleyeKelly LemeireAmanda GonçalvesElke DecrockSteven StaelensLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Kathrin WeberRia RoelandtInge BruggemanYann EstornesPeter Vandenabeele

A1 Journal Article in COMMUNICATIONS BIOLOGY

RIPK1-dependent cell death : a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie MartensVera GoossensLars DevisscherSam HofmansPolien ClaeysMarnik VuylstekeNozomi TakahashiKoen AugustynsPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization

Giel TangheCorinne UrwylerPhilippe De GrooteEmmanuel DejardinPieter-Jan De BockKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerMaria NordengrünHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda Gonçalves et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The pathological role of Cx43 and MLKL in TNF-induced systemic inflammatory response syndrome

Tinneke DelvaeyePeter VandenabeeleLuc LeybaertDmitri Krysko

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

Therapeutic targeting of connexin channels : new views and challenges

Tinneke DelvaeyePeter VandenabeeleGeert BultynckLuc LeybaertDmitri Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Tozasertib analogues as inhibitors of necroptotic cell death

Sam HofmansLars DevisscherSofie MartensDries Van RompaeyKenneth GoossensTatyana DivertWim NerinckxNozomi TakahashiHans De WinterPieter Van der Veken et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2

Alessandro AnnibaldiSidonie Wicky JohnTom Vanden BergheKirby N SwatekJianbin RuanGianmaria LiccardiKatiuscia BianchiPaul R ElliottSze Men ChoiSamya Van Coillie et al.

A1 Journal Article in MOLECULAR CELL

2017

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

C DelehouzeS Leverrier-PennaFabienne Le CannA ComteM Jacquard-FevaiO DelalandeN DesbanB BaratteI GallaisF Faurez et al.

A1 Journal Article in SCIENTIFIC REPORTS

Caractérisation de nouveaux inhibiteurs de la kinase RIPK1 et de la nécroptose

Fabienne Le CannMarie-Thérèse Dimanche-BoitrelPeter Vandenabeele

Development of biosensing systems to monitor necroptosis

Maria LadikPeter VandenabeeleFranck Riquet

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heme oxygenase activity and heme binding in a neonatal mouse model

Stephanie KourulaJoyce AngHui ZhaoFlora KalishPeter VandenabeeleKarl G SylvesterRonald J WongDavid K Stevenson

A1 Journal Article in NEONATOLOGY

How do we fit ferroptosis in the family of regulated cell death?

Howard O FearnheadPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease

Elodie KipF NazéV SuinTom Vanden BergheA FrancartS LamoralPeter VandenabeeleRudi BeyaertSteven Van GuchtM Kalai

A1 Journal Article in CELL DEATH DISCOVERY

Initiation and execution mechanisms of necroptosis : an overview

Sasker GrootjansTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ionizing radiation-induced cell death

Sandy Adjemian CataniKatrien VandecasteeleSofie MartensBartosz WiernickiTania Love AaesDmitri KryskoPeter Vandenabeele

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

Yves DondelingerTom DelangheDiego Rojas RiveraDario PriemTinneke DelvaeyeInge BruggemanFranky Van HerreweghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE CELL BIOLOGY

Modulation of Cx43 hemichannels by TNFα in HeLa cells overexpressing Cx43

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleDmitri KryskoLuc Leybaert

Necroptosis : (last) message in a bubble

Peter VandenabeeleFranck RiquetBenjamin Cappe

Editorial material

Necroptotic cell death in anti-cancer therapy

Olga KryskoTania Love AaesValerian E KaganKatharina D'HerdeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNOLOGICAL REVIEWS

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

Aveline FilliolMuhammad FarooqClaire Piquet-PellorceValentine GenetMarie-Thérèse Dimanche-BoitrelPeter VandenabeeleMathieu BertrandMichel SamsonJacques Le Seyec

A1 Journal Article in SCIENTIFIC REPORTS

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

Aveline FilliolClaire Piquet-PellorceCéline Raguénès-NicolSarah DionMuhammad FarooqCatherine Lucas-ClercPeter VandenabeeleMathieu BertrandJacques Le SeyecMichel Samson

A1 Journal Article in JOURNAL OF HEPATOLOGY

Role of necroptotic cancer cells in anti-cancer immunity

Dmitri KryskoTania Love AaesPeter Vandenabeele

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis

Fabienne Le CannClaire DelehouzéSabrina Leverrier-PennaAveline FilliolArnaud ComteOlivier DelalandeNathalie DesbanBlandine BaratteIsabelle GallaisClaire Piquet-Pellorce et al.

A1 Journal Article in FEBS JOURNAL

Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells

Friederike FeldmannBarbara SchenkSofie MartensPeter VandenabeeleSimone Fulda

A1 Journal Article in ONCOTARGET

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie MartensManhyung JeongWulf TonnusFriederike FeldmannSam HofmansVera GoossensNozomi TakahashiJan Hinrich BraesenEun-Woo LeePieter Van der Veken et al.

A1 Journal Article in CELL DEATH & DISEASE

Study of the functions of RIPK4 in epidermal development and signal transduction

Corinne UrwylerWim DeclercqPeter Vandenabeele

The impact of cell death modalities on the immunogenicity of cancer cells

Tania Love AaesPeter VandenabeeleDmitri Krysko

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

M JeongE-W LeeD SeongJ SeoJ-H KimSasker GrootjansS-Y KimPeter VandenabeeleJ Song

A1 Journal Article in ONCOGENE

When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas RiveraTinneke DelvaeyeRia RoelandtWim NerinckxKoen AugustynsPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress

Miguel AguiletaDiego Rojas RiveraVera GoossensYann EstornesGert Van IsterdaelPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

An evolutionary perspective on the necroptotic pathway

Yves DondelingerPaco HulpiauYvan SaeysMathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

An outline of necrosome triggers

Tom Vanden BergheBehrouz HassanniaPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Boosting apoptotic cell clearance by colonic epithelial cells attenuates inflammation in vivo

Chang Sup LeeKristen K PenberthyKaren M WheelerIgnacio J JuncadellaPeter VandenabeeleJeffrey J LysiakKodi Ravichandran

A1 Journal Article in IMMUNITY

Characterization of new proteins involved in apoptosis regulation

Miguel AguiletaMathieu BertrandPeter Vandenabeele

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

Jinho SeoEun-Woo LeeHyerim SungDaehyeon SeongYves DondelingerJihye ShinManhyung JeongHae-Kyung LeeJung-Hoon KimSu Yeon Han et al.

A1 Journal Article in NATURE CELL BIOLOGY

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

Simon D PouwelsG Jan ZijlstraMarco van der ToornLaura HesseRenee GrasNick HT ten HackenDmitri KryskoPeter VandenabeeleMaaike de VriesAntoon JM van Oosterhout et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DAMP-induced allograft and tumor rejection : the circle is closing

W. G. LandP. AgostinisS. GasserA. D. GargA. LinkermannPeter VandenabeeleTom Vanden BergheAdrian Zierleyn

A1 Journal Article in AMERICAN JOURNAL OF TRANSPLANTATION

Extracellular ATP and P₂X₇ receptor exert context-specific immunogenic effects after immunogenic cancer cell death

AD GargDmitri KryskoPeter VandenabeeleP Agostinis

A1 Journal Article in CELL DEATH & DISEASE

Ferroptosis : triggers, inhibitors and therapeutic potential in neuroblastoma

Behrouz HassanniaPeter VandenabeeleWim Vanden BergheTom Vanden Berghe

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

Philippe De GrooteSasker GrootjansSaskia LippensChantal EichpergerKirsten LeursIrene KahrGiel TangheInge BruggemanWouter De SchamphelaireCorinne Urwyler et al.

A1 Journal Article in BIOTECHNIQUES

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Özge CanliYasemin B AlankuşSasker GrootjansNaidu VegiLothar HültnerPhilipp S HoppeTimm SchroederPeter VandenabeeleGeorg W BornkammFlorian R Greten

A1 Journal Article in BLOOD

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

DJ KlionskyK AbdelmohsenA AbeMJ AbedinH AbeliovichAA ArozenaH AdachiCM AdamsPD AdamsK Adeli et al.

A1 Journal Article in AUTOPHAGY

Heterogeneity of the gut microbiome in mice : guidelines for optimizing experimental design

Debby LaukensBrigitta BrinkmanJeroen RaesMartine De VosPeter Vandenabeele

A1 Journal Article in FEMS MICROBIOLOGY REVIEWS

Identification of potential receptor interacting protein kinase 1 substrates during necroptosis

Sasker GrootjansPeter Vandenabeele

Immunogenic apoptotic cell death and anticancer immunity

Peter VandenabeeleKatrien VandecasteeleClaus BachertOlga KryskoDmitri Krysko

A1 Journal Article in Advances in Experimental Medicine and Biology

Necroptosis: a novel cell death modality and its potential relevance for critical care medicine

Gabriel Moreno-GonzalezPeter VandenabeeleDmitri Krysko

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

Mandy OJ GrootaertDorien M SchrijversHanne Van SpaendonkAnnelies BreynaertNina HermansViviane O Van HoofNozomi TakahashiPeter VandenabeeleSoon Ha KimGuido RY De Meyer et al.

A1 Journal Article in ATHEROSCLEROSIS

Novel ferroptosis inhibitors with improved potency and ADME properties

Sam HofmansTom Vanden BergheLars DevisscherBehrouz HassanniaSophie LyssensJurgen JoossensPieter Van Der VekenPeter VandenabeeleKoen Augustyns

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Regulated necrosis: disease relevance and therapeutic opportunities

Marcus ConradJosé Pedro Friedmann AngeliPeter VandenabeeleBrent R Stockwell

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Regulation of RIPK1's cell death function by phosphorylation

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Editorial material

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

Aveline FilliolClaire Piquet-PellorceJacques Le SeyecMuhammad FarooqValentine GenetCatherine Lucas-ClercJohn BertinPeter J GoughMarie-Thérèse Dimanche-BoitrelPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH & DISEASE

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Claudia GüntherGui-Wei HeAndreas E KremerJames M MurphyEmma J PetrieKerstin AmannPeter VandenabeeleAndreas LinkermannChristopher PorembaUlrike Schleicher et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

The tumor suppressor Hace1 is a critical regulator of TNFR1-mediated cell fate

Luigi TortolaRoberto NitschMathieu BertrandMelanie KoglerYounes RedouaneIvona KozieradzkiIris UribesalgoLilian M FennellMads DaugaardHelene Klug et al.

A1 Journal Article in CELL REPORTS

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

Rafia S Al-LamkiJun WangJun YangNatalie BurrowsPatrick H MaxwellTimothy EisenAnne Y WarrenSakari VanharantaSimon PaceyPeter Vandenabeele et al.

A1 Journal Article in ONCOTARGET

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensQuinten RemijsenPeter VandenabeeleRoberto MotterliniRomain Lefebvre

A1 Journal Article in TOXICOLOGY AND APPLIED PHARMACOLOGY

Development and validation of kinase activity reporters for the dynamic study of cell response modalities by microscopy

François SipieterFranck RiquetPeter VandenabeeleKatia Cailliau-MaggioLaurent Héliot

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

S SaveljevaSL Mc LaughlinPeter VandenabeeleA SamaliMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L GalluzziJM Bravo-San PedroI VitaleSA AaronsonJM AbramsD AdamES AlnemriL AltucciD AndrewsM Annicchiarico-Petruzzelli et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensTom Vanden BergheEvelien Van HammePeter VandenabeeleRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

Molecular and translational classifications of DAMPs in immunogenic cell death

Abhishek D GargLorenzo GalluzziLionel ApetohThais BaertRaymond B BirgeJosé Manuel Bravo-San PedroKarine BreckpotDavid BroughRicardo ChaurioMara Cirone et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

Tom Vanden BergheWilliam J KaiserMathieu BertrandPeter Vandenabeele

A2 Journal Article in MOLECULAR AND CELLULAR ONCOLOGY

Necroptosis and its role in inflammation

Manolis PasparakisPeter Vandenabeele

A1 Journal Article in NATURE

NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling

Yves DondelingerSandrine Jouan-LanhouetTatyana DivertEmilie TheatreJohn BertinPeter J GoughPiero GiansantiAlbert JR HeckEmmanuel DejardinPeter Vandenabeele et al.

A1 Journal Article in MOLECULAR CELL

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

L BoutaffalaMathieu BertrandC RemouchampsG SeleznikF ReisingerM JanasC BénézechMT FernandesS MarchettiF Mair et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

Barbora VeselaEva SvandovaTom Vanden BergheAbigail S TuckerPeter VandenabeeleEva Matalova

A1 Journal Article in JOURNAL OF MOLECULAR HISTOLOGY

Novel reporter for faithful monitoring of ERK2 dynamics in living cells and model organisms

François SipieterBenjamin CappeMariano Gonzalez PisfilCorentin SprietJean-François BodartKatia Cailliau-MaggioPeter VandenabeeleLaurent HéliotFranck Riquet

A1 Journal Article in PLOS ONE

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

Abhishek D GargSanne ElsenDmitri KryskoPeter VandenabeelePeter de WittePatrizia Agostinis

A1 Journal Article in ONCOTARGET

Unraveling the molecular mechanisms of RIPK1-mediated cell death

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Wavelet modeling and prediction of the stability of states: the Roman Empire and the European Union

Tatyana Y YaroshenkoDmitri KryskoVitalii DobriyanMaksim V ZhigalovHendrik VosPeter VandenabeeleVadim A Krysko

A1 Journal Article in COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION

2014

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

H MaesS Van EygenDmitri KryskoPeter VandenabeeleK NysK RillaertsAD GargT VerfaillieP Agostinis

A1 Journal Article in CELL DEATH & DISEASE

Caspase-3 and RasGAP: a stress-sensing survival/demise switch

Hadi KhalilMathieu BertrandPeter VandenabeeleChristian Widmann

A1 Journal Article in TRENDS IN CELL BIOLOGY

Consensus guidelines for the detection of immunogenic cell death

Oliver KeppLaura SenovillaIlio VitaleErika VacchelliSandy AdjemianPatrizia AgostinisLionel ApetohFernando ArandaVincenzo BarnabaNorma Bloy et al.

A1 Journal Article in ONCOIMMUNOLOGY

DAMPs activating innate and adaptive immune responses in COPD

SD PouwelsIH HeijinkNHT ten HackenPeter VandenabeeleDmitri KryskoMC NawijnAJM van Oosterhout

A1 Journal Article in MUCOSAL IMMUNOLOGY

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

Shane DeeganSvetlana SaveljevaSusan E LogueKarolina Pakos-ZebruckaSanjeev GuptaPeter VandenabeeleMathieu BertrandAfshin Samali

A1 Journal Article in AUTOPHAGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

Informaticawetenschappen in het leerplichtonderwijs

Giovanni SamaeyJacques Van RemortelHugues BersiniYvan BruynseraedeJan DekelverFrederik De LaenderDirk DeschoolmeesterPaul GistelinckBern MartensLennart Martens et al.

Is SIRT2 required for necroptosis?

Kim NewtonJoanne M HildebrandZhirong ShenDiego RodriguezSilvia Alvarez-DiazSean PetersenSaumil ShahDebra L DuggerChunzi HuangJohan Auwerx et al.

A1 Journal Article in NATURE

Methods to study and distinguish necroptosis

Sasker GrootjansVera GoossensPeter VandenabeeleTom Vanden Berghe

Bookchapter in Necrotic cell death

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

Necroptosis, in vivo detection in experimental disease models

Sandrine Jouan-LanhouetFranck RiquetLinde DuprezTom Vanden BergheNozomi TakahashiPeter Vandenabeele

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: a novel way of regulated necrosis with large pathophysiological implications

Peter VandenabeeleTom Vanden BergheNozomi Takahashi

Bookchapter in Pathobiology of human disease : a dynamic encyclopedia of disease mechanisms

Necrotic cell death

Non-apoptotic functions of caspase-7 during osteogenesis

E SvandovaHervé LesotTom Vanden BergheAS TuckerPT SharpePeter VandenabeeleE Matalova

A1 Journal Article in CELL DEATH & DISEASE

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent

Koen BreyneSteven CoolDieter DemonKristel DemeyereTom VandenberghePeter VandenabeeleHarald CarlsenWim Van Den BroeckNiek SandersEvelyne Meyer

A1 Journal Article in PLOS ONE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Tom Vanden BergheAndreas LinkermannSandrine Jouan-LanhouetHenning WalczakPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

Yann EstornesMiguel AguiletaChristel DubuissonJulie De KeyserVera GoossensKristof KersseA SamaliPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

Shining light on cell death processes: a novel biosensor for necroptosis, a newly described cell death program

François SipieterMaria LadikPeter VandenabeeleFranck Riquet

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synchronized renal tubular cell death involves ferroptosis

Andreas LinkermannRachid SkoutaNina HimmerkusSshrikant R MulayChristin DewitzFederica De ZenAgnes ProkaiGabriele ZuchtriegelFritz KrombachPatrick-Simon Welz et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter Vandenabeele et al.

A1 Journal Article in LABORATORY INVESTIGATION

The potential role of necroptosis in diseases

Andreas LinkermannTom Vanden BergheNozomi TakahashiUlrich KunzendorfStefan KrautwaldPeter Vandenabeele

Bookchapter in Necrotic cell death

The skin microbiome of caspase-14-deficient mice shows mild dysbiosis

Malgorzata KubicaFalk HildebrandBrigitta BrinkmanDirk GoossensJurgen Del FaveroKen VercammenPierre CornelisJens-Michael SchröderPeter VandenabeeleJeroen Raes et al.

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

2013

An inactivating caspase-11 passenger mutation muddles sepsis research

Tom Vanden BergheAlain GoethalsDieter DemonPieter BogaertTak W MakAnje CauwelsPeter Vandenabeele

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Kristof KerssePeter Vandenabeele

Bookchapter in Handbook of proteolytic enzymes

Caspase-14 overexpression in hairless mice is not involved in utricle formation

Michael DevosPhilippe De GrooteBarbara GilbertInge BruggemanKirsten LeursSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Caspase-14-deficient mice are more prone to the development of parakeratosis

Esther HosteGeertrui DeneckerBarbara GilbertFilip Van NieuwerburghLeslie van der FitsBob AsselberghRiet De RyckeJean-Pierre HachemDieter DeforceErrol P Prens et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caspase-3 and caspase-7

Tom Vanden BergheKristof KerssePeter Vandenabeele

Bookchapter in Handbook of proteolytic enzymes

Caspase-7 participates in differentiation of cells forming dental hard tissues

Eva MatalovaHerve LesotEva SvandovaTom Vanden BerghePaul T SharpeChristopher HealyPeter VandenabeeleAbigail S Tucker

A1 Journal Article in DEVELOPMENT GROWTH & DIFFERENTIATION

Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells

Kristof SchuttersDennis HM KustersMartijn LL ChatrouTrinidad Montero-MelendezMarjo DonnersNiko M DeckersDmitri KryskoPeter VandenabeeleMauro PerrettiLeon J Schurgers et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture

Kristel DemeyereQuinten RemijsenDieter DemonKoen BreyneSofie NotebaertFilip BoyenChristopher J GuérinPeter VandenabeeleEvelyne Meyer

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype

Brigitta BrinkmanAnne BeckerRene AyisehFalk HildebrandJeroen RaesGeert HuysPeter Vandenabeele

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

Falk Hildebrand(Thi Loan Anh NguyenBrigitta BrinkmanRoberto Garcia YuntaBenedicte CauwePeter VandenabeeleAdrian ListonJeroen Raes

A1 Journal Article in GENOME BIOLOGY

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleMathieu VinkenGeert BultynckDmitri Krysko et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Many faces of DAMPs in cancer therapy

Olga KryskoTania Love AaesClaus BachertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNITY

Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models

Peter VandenabeeleSasker GrootjansNico CallewaertNozomi Takahashi

Editorial material

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Yves DondelingerMiguel AguiletaVera GoossensChristel DubuissonSasker GrootjansE DejardinPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Role of cell death and caspases in intestinal inflammation

Rene AyisehPeter VandenabeeleBrigitta Brinkman

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

Abhishek D GargAleksandra M DudekGabriela B FerreiraTom VerfailliePeter VandenabeeleDmitri KryskoChantal MathieuPatrizia Agostinis

A1 Journal Article in AUTOPHAGY

Sensing of apoptotic and necroptotic cell death by the innate immune system

Agnieszka KaczmarekPeter VandenabeeleDmitri Krysko

The adjuvant-like activity of staphylococcal enterotoxin B in a murine asthma model is independent of IL-1R signaling

Olga KryskoTania MaesMaud PlantingaGabriële HoltappelsRosina ImiruPeter VandenabeeleGuy JoosDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Benjamin VandendriesscheElke RoggeVera GoossensPeter VandenabeeleJohannes-Peter StaschPeter BrouckaertAnje Cauwels

A1 Journal Article in PLOS ONE

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

Agnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxTania Love AaesTinneke DelvaeyeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

2012

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Abhishek D GargDmitri KryskoTom VerfaillieAgnieszka KaczmarekGabriela B FerreiraThiery MarysaelNoemi RubioMalgrozata FirczukChantal MathieuAnton JM Roebroek et al.

A1 Journal Article in EMBO JOURNAL

ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages

Gizem AynaDmitri KryskoAgnieszka KaczmarekGoran PetrovskiPeter VandenabeeleLászló Fésüs

A1 Journal Article in PLOS ONE

Autophagy: for better or for worse

Ellen WirawanTom Vanden BergheSaskia LippensPatrizia AgostinisPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

Beclin 1 : a role in membrane dynamics and beyond

Ellen WirawanSaskia LippensTom Vanden BergheAlessandra RomagnoliGian Maria FimiaMauro PiacentiniPeter Vandenabeele

A1 Journal Article in AUTOPHAGY

Caspase-7 in molar tooth development

E MatalovaTom Vanden BergheE SvandovaPeter VandenabeeleC HealyPT SharpeAS Tucker

A1 Journal Article in ARCHIVES OF ORAL BIOLOGY

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Stephanie VERSCHUERELiesbeth AllaisKen BrackeSaskia LippensRebecca De SmetPeter VandenabeeleGuy BrusselleClaude Cuvelier

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Contribution of ER stress to immunogenic cancer cell death

Abhishek D GargDmitri KryskoJakub GolabPeter VandenabeelePatrizia Agostinis

Bookchapter in Endoplasmic reticulum stress in health and disease

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike

Magdalena WejdaFrancis ImpensNozomi TakahashiPetra Van DammeKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress and inflammation

Abhsihek D GargAgnieszka KaczmarekDmitri KryskoPeter Vandenabeele

Bookchapter in Endoplasmic reticulum stress in health and disease

ER stress-induced inflammation: does it aid or impede disease progression?

Abhishek GargAgnieszka KaczmarekOlga KryskoPeter VandenabeeleDmitri KryskoPatrizia Agostinis

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke

Manuela MengozziIlaria CervelliniPia VillaZübeyde ErbayraktarNecati GökmenOsman YilmazSerhat ErbayraktarMathini ManohasandraPaul Van HummelenPeter Vandenabeele et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis

Michael DevosJanne PrawittDelphine Staumont-SalleEsther HosteSebastién FleuryEmmanuel BouchaertBarbara GilbertSaskia LippensPeter VandenabeeleDavid Dombrowicz et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ KlionskyFC AbdallaH AbeliovichRT AbrahamA Acevedo-ArozenaK AdeliL AgholmeM AgnelloP AgostinisJA Aguirre-Ghiso et al.

A1 Journal Article in AUTOPHAGY

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunogenic cell death and DAMPs in cancer therapy

Dmitri KryskoAbhishek D GargAgnieszka KaczmarekOlga KryskoPatrizia AgostinisPeter Vandenabeele

A1 Journal Article in NATURE REVIEWS CANCER

Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome

Makoto InoueKristi L WilliamsTimothy OliverPeter VandenabeeleJayant V RajanEdward A MiaoMari L Shinohara

A1 Journal Article in SCIENCE SIGNALING

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis

Linde DuprezMathieu BertrandTom Vanden BergheYves DondelingerNele FestjensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Paola TucciMassimiliano AgostiniFrancesca GrespiElke K MarkertAlessandro TerrinoniKaren H VousdenPatricia AJ MullerVolker DötschSebastian KehrloesserBerna S Sayan et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many stimuli pull the necrotic trigger, an overview

Nele VanlangenakkerTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

L GalluzziI VitaleJM AbramsES AlnemriEH BaehreckeMV BlagosklonnyTM DawsonVL DawsonWS El-DeiryS Fulda et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

V PagliariniEllen WirawanA RomagnoliF CiccosantiG LisiSaskia LippensF CecconiGM FimiaPeter VandenabeeleM Corazzari et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

S LoederM SchirmerH SchoenebergerS CristofanonJ LeibacherNele VanlangenakkerMathieu BertrandPeter VandenabeeleI JeremiasK-M Debatin et al.

A1 Journal Article in LEUKEMIA

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

Maria Regina Orofino KreugerSasker GrootjansMaique W BiavattiPeter VandenabeeleKatharina D'Herde

A1 Journal Article in ANTI-CANCER DRUGS

Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways

Agnieszka KaczmarekBrigitta BrinkmanLiesbeth HeyndrickxPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF PATHOLOGY

Study of RIPK4 function in skin homeostasis and disease

Philippe De GrooteWim DeclercqSaskia LippensPeter Vandenabeele

Study on the role of ΔNp63α and caspase-14 in skin homeostasis and pathology

Michael DevosWim DeclercqPeter Vandenabeele

The emergence of phox-ER stress induced immunogenic apoptosis

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

Editorial material

The flick of a switch: which death program to choose?

Peter VandenabeeleGennaro Melino

Editorial material

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

Marlies GalleShouguang JinPieter BogaertMira HaegmanPeter VandenabeeleRudi Beyaert

A1 Journal Article in PLOS ONE

The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

Peter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

Richard JägerMathieu BertrandAdrienne M GormanPeter VandenabeeleAfshin Samali

A1 Journal Article in BIOLOGY OF THE CELL

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

S Jouan-LanhouetMI ArshadC Piquet-PellorceC Martin-ChoulyG Le Moigne-MullerFranky Van HerrewegheNozomi TakahashiO SergentD Lagadic-GossmannPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoMathieu VinkenAgnieszka KaczmarekGiulia CrispinoMélissa BolNan WangMarijke De BockElke De VuystChristian C Naus et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010

Wim DeclercqP AgostinisPeter Vandenabeele

Editorial material

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter Vandenabeele et al.

A1 Journal Article in ALLERGY

Calcium and connexin-based intercellular communication, a deadly catch?

Elke DecrockMathieu VinkenMélissa BolKatharina D'HerdeVera RogiersPeter VandenabeeleDmitri KryskoGeert BultynckLuc Leybaert

A1 Journal Article in CELL CALCIUM

Caspase deficiency alters the murine gut microbiome

Brigitta BrinkmanF HildebrandMalgorzata KubicaD GoosensJ Del FaveroWim DeclercqJ RaesPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

Bookchapter in Apoptosis : physiology and pathology

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Nele VanlangenakkerTom Vanden BerghePieter BogaertBram LaukensK ZobelK DeshayesD VucicS FuldaPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

Abhishek D GargDmitri KryskoPeter VandenabeelePatrizia Agostinis

A1 Journal Article in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

Troy T RohnEllen WirawanRaquel J BrownJordan R HarrisEliezer MasliahPeter Vandenabeele

A1 Journal Article in NEUROBIOLOGY OF DISEASE

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim DeclercqNozomi TakahashiPeter Vandenabeele

Editorial material

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

Quinten RemijsenTW KuijpersEllen WirawanSaskia LippensPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Effect of LPS, dsRNA or interferons on the phagocytosis of dying cells or mycobacteria by macrophages

Frederic VanzemberghGreet BrouckaertFlorence NazéSteven Van GuchtTom Vanden BergheDmitri KryskoPeter VandenabeeleMichael Kalai

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

Dmitri KryskoPatrizia AgostinisOlga KryskoAbhishek D GargClaus BachertBart LambrechtPeter Vandenabeele

A1 Journal Article in TRENDS IN IMMUNOLOGY

Fine-tuning nucleophosmin in macrophage differentiation and activation

Leslie GueryNaima BenikhlefThomas GautierCatherine PaulGaetan JegoErick DufourArnaud JacquelRadj CallyBenedicte ManouryTom Vanden Berghe et al.

A1 Journal Article in BLOOD

In vitro characterization of bovine neutrophil cell death following Escherichia coli phagocytosis

Sofie NotebaertKristel DemeyereDieter DemonFilip BoyenChris GuerinPeter VandenabeeleEvelyne Meyer

Inflammasome modulation and NF-κB activation by caspase-1-related CARD domains

Kristof KerssePeter VandenabeeleTom Vanden BergheMathieu Bertrand

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Kristof KersseMohamed LamkanfiMathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Jurg Tschopp-1951-2011-an immortal contribution Obituary

G KroemerF MartinonSaskia LippensDR GreenR KnightPeter VandenabeeleM PiacentiniS NagataC BornerHU Simon et al.

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

S IvanovaU GregorcN VidergarR JavierDS BredtPeter VandenabeeleJ PardoMM SimonV TurkL Banks et al.

A1 Journal Article in CELL DEATH & DISEASE

Molecular interplay between autophagy and apoptosis through caspase-mediated cleavage of Beclin-1

Ellen WirawanPeter VandenabeeleSaskia Lippens

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Quinten RemijsenTom Vanden BergheEllen WirawanBob AsselberghEef ParthoensRiet De RyckeSamuel NoppenMichel DelforgeJean WillemsPeter Vandenabeele

A1 Journal Article in CELL RESEARCH

NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation

Sharen ProvoostTania MaesNele PauwelsTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosKurt Tournoy

A1 Journal Article in JOURNAL OF IMMUNOLOGY

NOD-like receptors and the innate immune system: coping with danger, damage and death

Kristof KersseMathieu BertrandMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Programmed necrosis : from molecules to health and disease

Lorenzo GalluzziTom Vanden BergheNele VanlangenakkerSabrina BuettnerTobias EisenbergPeter VandenabeeleFrank MadeoGuido Kroemer

A1 Journal Article in International Review of Cell and Molecular Biology

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

NS PauwelsKen BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of RIP1 in TNF-induced cell death in vitro and in vivo

Linde DuprezPeter VandenabeeleNozomi Takahashi

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Bram LaukensClaudia JenneweinBarbara SchenkNele VanlangenakkerAlexander SchierSilvia CristofanonKerry ZobelKurt DeshayesDomagoj VucicIrmela Jeremias et al.

A1 Journal Article in NEOPLASIA

The death-fold superfamily of homotypic interaction motifs

Kristof KersseJelle VerspurtenTom Vanden BerghePeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

The in vivo role of executioner caspase-3 and -7 in the Escherichia coli-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

The Ripoptosome: death decision in the Cytosol

Mathieu BertrandPeter Vandenabeele

Editorial material

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

Dmitri KryskoAgnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxJerzy WoznickiPieter BogaertAnje CauwelsNozomi TakahashiS MagezClaus Bachert et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

Nele VanlangenakkerMathieu BertrandPieter BogaertPeter VandenabeeleTom Vanden Berghe

A1 Journal Article in CELL DEATH & DISEASE

Unraveling TNF-induced necrotic signaling pathways using RNA interference and live-cell imaging

Nele VanlangenakkerPeter VandenabeeleTom Vanden Berghe

Workshop summary: cell death mechanisms controlled by the TNF family

JE ErikssonPeter Vandenabeele

A1 Journal Article in Advances in Experimental Medicine and Biology

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

Dmitri KryskoPeter Vandenabeele

Editorial material

Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis

Araceli Diez FraileSylvie MusscheTom Vanden BergheMarc EspeelPeter VandenabeeleKatharina D'Herde

A1 Journal Article in ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY

Hydroxylase inhibition abrogates TNF-α-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersKim OlievierSara BogaertBrigitta BrinkmanPeter VandenabeeleDirk Elewaut et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

AD GargD NowisJ GolabPeter VandenabeeleDmitri KryskoP Agostinis

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases

Olga KryskoPeter VandenabeeleDmitri KryskoClaus Bachert

A1 Journal Article in APOPTOSIS

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter VandenabeeleLorenzo GalluzziTom Vanden BergheGuido Kroemer

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

MYD88, TLR-2, TLR-9 and TNFR1-dependent signaling is essential for the sterile inflammatory response triggered by doxorubicin

Dmitri KryskoAgnieszka KaczmarekJerzy WoznickiStefan MagezOlga KryskoPieter BogaertPeter Vandenabeele

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Tom Vanden BergheNele VanlangenakkerEef ParthoensWies DeckersMichael DevosNele FestjensChris GuerinUT BrunkWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Oxygen sensor inhibition attenuates TNF-α induced intestinal epithelial damage by hypoxia inducible factor (HIF) 1-dependent repression of fas-associated death domain protein (Fadd)

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

RIP1's function in NF-kappa B activation: from master actor to onlooker

Mathieu BertrandPeter Vandenabeele

Editorial material

Role of caspase-7 during early involution of the Escherichia coli- or the Staphylococcus aureus-infected mammary gland

Koen BreyneDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

Study of the role of caspase-14 in epidermal cornification

Esther HosteWim DeclercqPeter Vandenabeele

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Peter VandenabeeleWim DeclercqFranky Van HerrewegheTom Vanden Berghe

A1 Journal Article in SCIENCE SIGNALING

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

Franky Van HerrewegheNele FestjensWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2009

Caspase substrates: easily caught in deep waters?

Dieter DemonPetra Van DammeTom Vanden BergheJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeelePatrizia AgostinisWim Declercq

A1 Journal Article in APOPTOSIS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

G KroemerL GalluzziPeter VandenabeeleJ AbramsES AlnemriEH BaehreckeMV BlagosklonnyWS El-DeiryP GolsteinDR Green et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Connexin-related signaling in cell death: to live or let die?

Elke DecrockMathieu VinkenElke De VuystDmitri KryskoKatharina D'HerdeTamara VanhaeckePeter VandenabeeleVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Death receptor-induced necroptosis

Wim DeclercqFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Encyclopedia of life sciences

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

L GalluzziSA AaronsonJ AbramsES AlnemriDW AndrewsEH BaehreckeNG BazanMV BlagosklonnyK BlomgrenC Borner et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt

Quinten RemijsenTom Vanden BergheEef ParthoensBob AsselberghPeter VandenabeeleJean Willems

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Major cell death pathways at a glance

Linde DuprezEllen WirawanTom Vanden BerghePeter Vandenabeele

A1 Journal Article in MICROBES AND INFECTION

Mitotic catastrophe as a prestage to necrosis in mouse liver cells treated with Helicobacter pullorum sonicates

Liesbeth M CeelenFreddy HaesebrouckKatharina D'HerdeDmitri KryskoHerman FavoreelPeter VandenabeeleRichard DucatelleAnnemie Decostere

A1 Journal Article in JOURNAL OF MORPHOLOGY

Molecular pathways of different types of cell death: many roads to death

Dmitri KryskoAgnieszka KaczmarekPeter Vandenabeele

Bookchapter in Phagocytosis of dying cells: from molecular mechanisms to human diseases

Necrosis: molecular mechanisms and physiological roles

Linde DuprezNele VanlangenakkerNele FestjensFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Essentials of apoptosis : a guide for basic and clinical research

Phagocytosis of dying cells: from molecular mechanisms to human diseases

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

Dieter DemonPetra Van DammeTom Vanden BergheAnnelies DeceuninckJoost Van DurmeJelle VerspurtenKenny HelsensFrancis ImpensMagdalena WejdaJoost Schymkowitz et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Reconstitution of protection against Aspergillus infection in chronic granulomatous disease (CGD)

Quinten RemijsenPeter VandenabeeleJean WillemsTaco Kuijpers

A1 Journal Article in BLOOD

RIP Kinases at the Crossroads of Cell Death and Survival

Wim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL

SitePredicting the cleavage of proteinase substrates

Jelle VerspurtenKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases

Alexander U. LuthiSean P. CullenEdel A. McNeelaPatrick J. DuriezInna AfoninaClare SheridanGabriela BrumattiRebecca C. TaylorKristof KerssePeter Vandenabeele et al.

A1 Journal Article in IMMUNITY

The emerging roles of serine protease cascades in the epidermis

Petra OvaereSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

Acute modulations in permeability barrier function regulate epidermal cornification - Role of caspase-14 and the protease activated receptor type 2

M DEMERJIANJP HACHEME TSCHACHLERGeertrui DeneckerWim DeclercqPeter VandenabeeleT MAUROM HUPED CRUMRINET ROELANDT et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Apoptosis and necrosis: Detection, discrimination and phagocytosis

Dmitri KryskoTom Vanden BergheKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS

Apoptosome and caspase activation

Wim DeclercqPeter Vandenabeele

Bookchapter in Wiley Encyclopedia of Chemical Biology

Caspase-14 reveals its secrets

Geertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Kristof KersseWim DeclercqPeter Vandenabeele

Bookchapter in Encyclopedia of molecular pharmacology

Creation and x-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

H SHIBATAY YOSHIOKAA OHKAWAK MINOWAY MUKAIY ABEM TANIAIT NOMURAH KAYAMUROH NABESHI et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

From regulation of dying cell engulfment to development of anti-cancer therapy

Dmitri KryskoPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

In vivo imaging of NF-kappa B activity during Escherichia coli-induced mammary gland infection

Sofie NotebaertHarald CarlsenDaniel JanssenPeter VandenabeeleRune BlomhoffEvelyne Meyer

A1 Journal Article in CELLULAR MICROBIOLOGY

Inflammatory mediators in Escherichia coli-induced mastitis in mice

Sofie NotebaertDieter DemonTom Vanden BerghePeter VandenabeeleEvelyne Meyer

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Life and death of female gametes during oogenesis and folliculogenesis

Dmitri KryskoAraceli Diez FraileGodelieve CrielAndrei SvistunovPeter VandenabeeleKatharina D'Herde

A1 Journal Article in Apoptosis

Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

Dmitri KryskoTom Vanden BergheEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in METHODS IN ENZYMOLOGY

Molecular mechanisms and pathophysiology of necrotic cell death

Nele VanlangenakkerTom Vanden BergheDmitri KryskoNele FestjensPeter Vandenabeele

A1 Journal Article in CURRENT MOLECULAR MEDICINE

Necrotic cell death and 'necrostatins': now we can control cellular explosion

Peter VandenabeeleWim DeclercqTom Vanden Berghe

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Role of Caspases in inflammation-driven diseases

Kristof KersseTom Vanden BergheSaskia LippensWim DeclercqPeter Vandenabeele

Bookchapter in Design of Caspase inhibitors as potential clinical agents

SELECTIVE STIMULATION OF EITHER TUMOR NECROSIS FACTOR RECEPTOR DIFFERENTIALLY INDUCES PAIN BEHAVIOR IN VIVO AND ECTOPIC ACTIVITY IN SENSORY NEURONS IN VITRO

M SCHAFERSC SOMMERC GEIST HAGENACKERPeter VandenabeeleLS SORKIN

A1 Journal Article in NEUROSCIENCE

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

Mohamed LamkanfiThirumala-Devi KannegantiPetra Van DammeTom Vanden BergheIsabel VanoverbergheJoël VandekerckhovePeter VandenabeeleKris GevaertGabriel Nuñez

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

The mitochondrial serine protease HtrA2/Omi: an overview

Lieselotte Vande WalleMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

L DelmulleTom Vanden BergheDenis De KeukeleirePeter Vandenabeele

A1 Journal Article in PHYTOTHERAPY RESEARCH

2007

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Kristof KersseTom Vanden BergheMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Are metacaspases caspases?

Dominique VercammenWim DeclercqPeter VandenabeeleFrank Van Breusegem

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

G SCHILDERSR RAIJMAKERSKCR MALMEGRIMLieselotte Vande WalleXavier SaelensWV EGBERTSWJ VAN VENROOIJPeter VandenabeeleGJM PRUIJN

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Caspases in cell survival, proliferation and differentiation

Mohamed LamkanfiNele FestjensWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Cell death types at a glance

Dmitri KryskoPeter VandenabeeleKatharina D'Herde

Bookchapter in Cell Apoptosis Research Advances

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs (Poster by O. Thomas)

Olivier ThomasEtienne SchachtPeter Vandenabeele

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs. Poster P49 by O. Thomas

Olivier ThomasEtienne SchachtPeter Vandenabeele

Generation of active recombinant human caspase-14

Philippe De GrootePetra OvaereEsther HosteGeertrui DeneckerSaskia LippensPeter VandenabeeleWim Declercq

Identification and characterization of filaggrin as a caspase-14 substrate

Esther HosteGeertrui DeneckerPetra Van DammeRB PRESLANDJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Inflammatory caspases : targets for novel therapies

Sigrid CornelisKristof KersseNele FestjensMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

NADPH oxidases: new players in TNIF-induced necrotic cell death

Tom Vanden BergheWim DeclercqPeter Vandenabeele

Editorial material

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling

TD KANNEGANTIMohamed LamkanfiYG KIMG CHENJH PARKL FRANCHIPeter VandenabeeleG NUNEZ

A1 Journal Article in IMMUNITY

Permeability barrier requirements regulate keratinocyte cornification: role of caspase 14 and the protease-activated receptor type 2

M DEMERJIANJ HACHEME TSCHACHLERGeertrui DeneckerWim DeclercqPeter VandenabeeleTM MAUROD CRUMRINET ROELANDTE HOUBEN et al.

Proteome-wide identification of HtrA2/Omi substrates

Lieselotte Vande WallePetra Van DammeMohamed LamkanfiXavier SaelensJoël VandekerckhoveKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

RIP1, a kinase on the crossroads of a cell's decision to live or die

Nele FestjensTom Vanden BergheSigrid CornelisPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation

Michaël KalaiV SUINNele FestjensAnn MeeusA BERNISXM WANGXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

Mohamed LamkanfiA AMERTD KANNEGANTIR MUNOZ-PLANILLOG CHENPeter VandenabeeleA FORTIERP GROSG NUNEZ

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2006

Apoptosis and necrosis, two fundamental alternatives

Peter Vandenabeele

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

TD KANNEGANTIN OZORENM BODY-MALAPELA AMERJH PARKL FRANCHIJ WHITFIELDW BARCHETM COLONNAPeter Vandenabeele et al.

A1 Journal Article in NATURE

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

Nele FestjensMichaël KalaiJoél SmetAnn MeeusRudy Van CosterXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspase inhibitors promote alternative cell death pathways

Peter VandenabeeleTom Vanden BergheNele Festjens

A4 Journal Article in Science Signal Transduction Knowledge Environment

Caspase-containing complexes in the regulation of cell death and inflammation

Nele FestjensSigrid CornelisMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOLOGICAL CHEMISTRY

Caspases leave the beaten track: caspase-mediated activation of NF-kappa B

Mohamed LamkanfiWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Cell death: initiation, propagation and clearance

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

Clearance of apoptotic and necrotic cells and its immunological consequences

Dmitri KryskoKatharina D'HerdePeter Vandenabeele

A1 Journal Article in APOPTOSIS

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1 beta in salmonella-infected macrophages

L FRANCHIA AMERM BODY-MALAPELTD KANNEGANTIN OZORENR JAGIRDARN INOHARAPeter VandenabeeleJ BERTINA COYLE et al.

A1 Journal Article in NATURE IMMUNOLOGY

Design and targeted delivery of novel peptide-based compounds as sensitizers of cell death induction by chemotherapeutic drugs (Poster by O. Thomas)

Olivier ThomasEtienne SchachtPeter Vandenabeele

Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

Dmitri KryskoGeertrui DeneckerNele FestjensSofie GabriëlsEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necrosis is associated with IL-6 production but apoptosis is not

Tom Vanden BergheMichaël KalaiGeertrui DeneckerAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

Nele FestjensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

Role of mitochondrial proteins in apoptosis.

Xavier SaelensNele FestjensLieselotte Vande WallePeter Vandenabeele

Bookchapter in Apoptosis and cancer therapy

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMaria (Marjan) van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1

Sigrid CornelisYanik BruynoogheGeert van LooXavier SaelensPeter VandenabeeleRudi Beyaert

A1 Journal Article in ONCOGENE

Apoptotic pathways and their regulation

Greet BrouckaertMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Apoptotic pathways as targets for novel therapies in cancer and other diseases

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

G KROEMERW EL-DEIRYP GOLSTEINME PETERD VAUXPeter VandenabeeleB ZHIVOTOVSKYMV BLAGOSKLONNYW MALORNIRA KNIGHT et al.

Editorial material

Death penalty for keratinocytes: apoptosis versus cornification

Saskia LippensGeertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Fas induced necrosis.

Tom Vanden BergheNele FestjensMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Fas Signaling

Gap junctions and the propagation of cell survival and cell death signals

Dmitri KryskoLuc LeybaertPeter VandenabeeleKatharina D'Herde

A1 Journal Article in APOPTOSIS

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

Bart DepuydtGeert van LooPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL SCIENCE

Mitochondria: Breathe or die

Lieselotte Vande WalleNele FestjensXavier SaelensPeter Vandenabeele

Bookchapter in Apoptosis

Protein synthesis persists during necrotic cell death

Xavier SaelensNele FestjensEef ParthoensIsabel VanoverbergheMichaël KalaiF VAN KUPPEVELDPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand

J LiuMQ ZhaoLM XuCV RamanaWim DeclercqPeter VandenabeeleRI Enelow

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera

Peter VandenabeeleS ORRENIUSB ZHIVOTOVSKY

Editorial material

TNFR1-and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury

RS AL-LAMKIJ WANGPeter VandenabeeleJA BRADLEYS THIRUDH LUOW MINJS POBERJR BRADLEY

A1 Journal Article in FASEB JOURNAL

2004

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

A VAN LAETHEMS VAN KELSTSaskia LippensWim DeclercqPeter VandenabeeleS JANSSENSJR VANDENHEEDEM GARMYNP AGOSTINIS

A1 Journal Article in FASEB JOURNAL

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

Mohamed LamkanfiMichaël KalaiXavier SaelensWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-12: an overview

Mohamed LamkanfiMichaël KalaiPeter Vandenabeele

Editorial material

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMaria (Marjan) van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells

N VANDERHEYDEPeter VandenabeeleM GOLDMANF WILLEMS

A1 Journal Article in IMMUNOLOGY LETTERS

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

T VANTUSD VERTOMMENXavier SaelensA RYKXL DE KIMPES VANCAUWENBERGHS MIKHALAPE WAELKENSG KERIT SEUFFERLEIN et al.

A1 Journal Article in CELLULAR SIGNALLING

Identification of protein-protein interactions in cell death signalling using the yeast two-hybrid system

Maria Francisca van GurpPeter Vandenabeele

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

More than one way to die: methods to determine TNF-induced apoptosis and necrosis

Tom Vanden BergheGeertrui DeneckerGreet BrouckaertDmitri KryskoKatharina D'HerdePeter Vandenabeele

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

Greet BrouckaertMichaël KalaiDmitri KryskoXavier SaelensDominique VercammenMatladi NdlovuGuy HaegemanKatharina D'HerdePeter Vandenabeele

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1 beta

Peter SchotteGeertrui DeneckerAeke Van Den BroekePeter VandenabeeleGR CORNELISRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The use of proteomics in the study of cell death

Xavier SaelensG VAN LOOKris GevaertJoël VandekerckhovePeter Vandenabeele

Bookchapter in When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

Toxic proteins released from mitochondria in cell death

Xavier SaelensNele FestjensLieselotte Vande WalleMaria (Marjan) van GurpGeert van LooPeter Vandenabeele

A1 Journal Article in ONCOGENE

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

Saskia LippensM KOCKXGeertrui DeneckerM KNAAPENA VERHEYENR CHRISTIAENE TSCHACHLERPeter VandenabeeleWim Declercq

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

Nele FestjensMaria (Marjan) van GurpGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in ACTA HAEMATOLOGICA

Caspase-1 and caspase-8 cleave and inactivate cellular parkin

S KAHNSMichaël KalaiLD JAKOBSENBFC CLARKPeter VandenabeelePH JENSEN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies

Saskia LippensCaroline Van den BroeckeElke Van DammeE TschachlerPeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis

KCRM DE FARIASXavier SaelensGJM PRUIJNPeter VandenabeeleWJ VAN VENROOIJ

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Tom Vanden BergheMichaël KalaiGeert van LooWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct regulation of cytosolic phospholipase A(2) phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

OJ JUPPPeter VandenabeeleDJ MACEWAN

A1 Journal Article in BIOCHEMICAL JOURNAL

Inhibition of nuclear factor-kappa B by a nitro-derivative of flurbiprofen: A possible mechanism for antiinflammatory and antiproliferative effect

M FRATELLIM MINTOA CRESPIE ERBAPeter VandenabeeleP DEL SOLDATOP GHEZZI

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

J ROZMAN-PUNGERCARN KOPITAR-JERALAM BOGYOD TURKO VASILJEVAI STEFEPeter VandenabeeleD BROMMEV PUIZDARM FONOVIC et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

MJ FRAMER TATEDR ADAMSKM MORGANMD HOUSLAYPeter VandenabeeleNJ PYNE

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

Dmitri KryskoGreet BrouckaertMichaël KalaiPeter VandenabeeleKatharina D'Herde

A1 Journal Article in JOURNAL OF MORPHOLOGY

Mitochondrial intermembrane proteins in cell death

Maria (Marjan) van GurpNele FestjensGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappa B signaling

AF LITTLEJOHNSJ TUCKERAAA MOHAMEDS MCKAYMJ HELMSPeter VandenabeeleDJ MACEWAN

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases

Tineke LauwaetMaria José OliveiraBert CallewaertGeorges De BruyneXavier SaelensSerge AnkriPeter VandenabeeleDavid MirelmanMarcus MareelAncy Leroy

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerM BoogmansSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The caspase family

Mohamed LamkanfiWim DeclercqBart DepuydtMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Caspases-Their Role in Cell Death and Cell Survival

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: Role in the Ca2+ sensitization of myosin light chain(20) phosphorylation

I HUNTERHJ COBBANPeter VandenabeeleDJ MACEWANGF NIXON

A1 Journal Article in MOLECULAR PHARMACOLOGY

Type II autophagic cell death and death-associated protein kinases

Xavier SaelensPeter Vandenabeele

A2 Journal Article in Chemtracts. Biochemistry and molecular biology

2002

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

Geert van LooHans DemolMaria (Marjan) van GurpB HoorelbekePeter SchotteRudi BeyaertB ZhivotovskyKris GevaertWim DeclercqJoël Vandekerckhove et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

Mohamed LamkanfiWim DeclercqMichaël KalaiXavier SaelensPeter Vandenabeele

Editorial material

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Differential activation of nuclear factor-kappa B by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly.

SM MCFARLANEG PASHMIMC CONNELLAF LITTLEJOHNSJ TUCKERPeter VandenabeeleDJ MACEWAN

A1 Journal Article in FEBS LETTERS

Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells.

J VARGHESEH SADEPeter VandenabeeleA SARIN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas

Rudi BeyaertGeert van LooKaren HeyninckPeter Vandenabeele

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail.

H STOREYA STEWARTPeter VandenabeeleJP LUZIO

A1 Journal Article in BIOCHEMICAL JOURNAL

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

Geert van LooXavier SaelensMaria (Marjan) van GurpM MACFARLANESJ MARTINPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

Geert van LooMaria (Marjan) van GurpBart DepuydtSM SRINIVASULAI RODRIGUEZES ALNEMRIKris GevaertJoël VandekerckhoveWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Michaël KalaiGeert van LooTom Vanden BergheAnn MeeusWilhelmina BurmXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

J POLLOCKSM MCFARLANEMC CONNELLU ZEHAVIPeter VandenabeeleDJ MACEWANRH SCOTT

A1 Journal Article in NEUROPHARMACOLOGY

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

A MOHAMEDOJ JUPPHM ANDERSONAF LITTLEJOHNPeter VandenabeeleDJ MACEWAN

A1 Journal Article in BIOCHEMICAL JOURNAL

2001

Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion.

M DAEMENGeertrui DeneckerC VAN'T VEERT WOLFSPeter VandenabeeleWA BUURMAN

A1 Journal Article in TRANSPLANTATION

Apoptotic and necrotic cell death induced by death domain receptors.

Geertrui DeneckerD VERCAMMENWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalter FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.

A VANTIEGHEMY XUPeter VandenabeeleGeertrui DeneckerJR VANDENHEEDEW MERLEVEDEPA DE WITTEP AGOSTINIS

A1 Journal Article in PHOTOCHEMISTRY AND PHOTOBIOLOGY

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation

Geert van LooPeter SchotteMaria (Marjan) van GurpHans DemolB HOORELBEKEKris GevaertI RODRIGUEZA RUIZ-CARRILLOJoël VandekerckhoveWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Heterotrimers formed by tumor necrosis factors of different species or muteins.

Paul AmelootWim DeclercqWalter FiersPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Paul AmelootWalter FiersPieter De BleserCF WAREPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein.

Peter SchotteGeert van LooIsabelle CarpentierPeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse mammary gland involution is associated with cytochrome c release and caspase activation.

A MARTIPM RITTERR JAGERH LAZARA BALTZERJ SCHENKELWim DeclercqPeter VandenabeeleR JAGGI

A1 Journal Article in MECHANISMS OF DEVELOPMENT

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle.

SM MCFARLANEOJ JUPPHJ COBBANI HUNTERHM ANDERSONPeter VandenabeeleGF NIXONDJ MACEWAN

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component.

V SHALAKM KAMINSKAR MITNACHT-KRAUSPeter VandenabeeleM CLAUSSM MIRANDE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.

M FRAMEKF WANR TATEPeter VandenabeeleNJ PYNE

A1 Journal Article in CELLULAR SIGNALLING

The somatostatin analogue TT-232 induces apoptosis in A431 cells - Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.

T VANTUSG KERIZ KRIVICKIENEM VALIUSA STETAKS KEPPENSP CSERMELYPI BAUERG BOKONYIWim Declercq et al.

A1 Journal Article in CELLULAR SIGNALLING

Translation inhibition in apoptosis - Caspase-dependent PKR activation and eIF2-alpha phosphorylation.

Xavier SaelensMichaël KalaiPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Tumoricidal activity of monocyte-derived dendritic cells: Evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism.

N VANDERHEYDEE AKSOYZ AMRAOUIPeter VandenabeeleM GOLDMANFrans Willems

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAR pathways.

OJ JUPPSM MCFARLANEHM ANDERSONAF LITTLEJOHNAAA MOHAMEDRH MACKAYPeter VandenabeeleDJ MACEWAN

A1 Journal Article in BIOCHEMICAL JOURNAL

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid.

Geertrui DeneckerWim DeclercqC GEUIJENA BOLANDR BENABDILLAHMaria (Marjan) van GurpMP SORYPeter VandenabeeleGR CORNELIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

LC PENNINGGeertrui DeneckerD VERCAMMENWim DeclercqRG SCHIPPERPeter Vandenabeele

A1 Journal Article in CYTOKINE

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.

Saskia LippensM KOCKXM KNAAPENL MORTIERR POLAKOWSKAA VERHEYENM GARMYNA ZWIJSENP FORMSTECHERD HUYLEBROECK et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation.

M DAEMENVH HEEMSKERKC VAN 'T VEERGeertrui DeneckerTGAM WOLFSPeter VandenabeeleWA BUURMAN

A1 Journal Article in CIRCULATION

How cells die counts - Reply.

M DAEMENPeter VandenabeeleWA BUURMAN

Editorial material

p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.

Z ASSEFAA VANTIEGHEMM GARMYNWim DeclercqPeter VandenabeeleJR VANDENHEEDER BOUILLONW MERLEVEDEP AGOSTINIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Role of reactive oxygen species in tumor necrosis factor toxicity

Vera GoossensKurt De VosDominique VercammenMargino SteemansKatia VancompernolleWalter FiersPeter VandenabeeleJohan Grooten

Bookchapter in Antioxidant and redox regulation of genes

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeN DE WAELD VERCAMMENWalter FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.

L ECKHARTWim DeclercqJ BANM RENDLB LENGAUERC MAYERSaskia LippensPeter VandenabeeleE TSCHACHLER

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3 - Consequences for altered intracellular distribution.

E HUSTONM BEARDF MCCALLUMNJ PYNEPeter VandenabeeleG SCOTLANDMD HOUSLAY

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.

HA BEHRENSDORFMarc Van De CraenUE KNIESPeter VandenabeeleM CLAUSS

A1 Journal Article in FEBS LETTERS

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

S PYPEWim DeclercqA IBRAHIMIC MICHIELSJGI VAN RIETSCHOTENN DEWULFM DE BOERPeter VandenabeeleD HUYLEBROECKJE REMACLE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins.

Wim Van MolleGeertrui DeneckerI RODRIGUEZPeter BrouckaertPeter VandenabeeleClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27(Kip1) mediates its anti-apoptotic activity.

B EYMINO SORDETN DROINB MUNSCHM HAUGGMarc Van De CraenPeter VandenabeeleE SOLARY

A1 Journal Article in ONCOGENE

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.

A RICKERSN PETERSV BADOCKRudi BeyaertPeter VandenabeeleB DORKENK BOMMERT

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

GAL4 is a substrate for caspases : implications for two-hybrid screening and other GAL4-based assays

Wim Van CriekingeSigrid CornelisMarc Van De CraenPeter VandenabeeleWalter FiersRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.

Marc Van De CraenC DE JONGHEI VAN DEN BRANDEWim DeclercqG VAN GASSENWim Van CriekingeI VANDERHOEVENWalter FiersC VAN BROECKHOVENL HENDRIKS et al.

A1 Journal Article in FEBS LETTERS

Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.

M DAEMENC VAN'T VEERGeertrui DeneckerVH HEEMSKERKT WOLFSM CLAUSSPeter VandenabeeleWA BUURMAN

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Jerusalem of cytokines

Ben-Zion LeviAntonio SicaGerhard Müller-NewenNozomi TakahashiPeter VandenabeeleEleanor Fish

More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Walter FiersRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in ONCOGENE

Non-specific effects of methyl ketone peptide inhibitors of caspases.

Peter SchotteWim DeclercqSofie Van HuffelPeter VandenabeeleRudi Beyaert

A1 Journal Article in FEBS LETTERS

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.

D FERRARIM LOSM BAUERPeter VandenabeeleS WESSELBORGK SCHULZE-OSTHOFF

A1 Journal Article in FEBS LETTERS

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.

Marc Van De CraenGeert BerxI VAN DEN BRANDEWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Redox regulation of TNF signaling.

Vera GoossensKurt De VosD VERCAMMENMargino SteemansK VANCOMPERNOLLEWalter FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in BIOFACTORS

The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.

Z ASSEFAA VANTIEGHEMWim DeclercqPeter VandenabeeleJR VANDENHEEDEW MERLEVEDEP DE WITTEP AGOSTINIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The proteolytic procaspase activation network: an in vitro analysis.

Marc Van De CraenWim DeclercqI VAN DEN BRANDEWalter FiersPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.

PR FARACOEC LEDGERWOODPeter VandenabeeleJB PRINSJR BRADLEY

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression.

GT BAXTERRC KUOOJ JUPPPeter VandenabeeleDJ MACEWAN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1998

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

Margino SteemansVera GoossensMarc Van De CraenF VAN HERREWEGHEKatia VancompernolleKurt De VosPeter VandenabeeleJohan Grooten

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.

Katia VancompernolleF VAN HERREWEGHEGwenda PynaertMarc Van De CraenKurt De VosN TOTTYA STERLINGWalter FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in FEBS LETTERS

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalter Fiers et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.

Wim DeclercqGeertrui DeneckerWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.

Dominique VercammenGreet BrouckaertGeertrui DeneckerMarc Van De CraenWim DeclercqWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis - Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.

A VANTIEGHEMZ ASSEFAPeter VandenabeeleWim DeclercqS COURTOISJR VANDENHEEDEW MERLEVEDEP DE WITTEP AGOSTINIS

A1 Journal Article in FEBS LETTERS

Identification of a new caspase homologue: caspase-14.

Marc Van De CraenGeert van LooS PYPEWim Van CriekingeI VAN DEN BRANDEFrancis MolemansWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Molecular cloning and identification of murine caspase-8.

M VAN DE CRAENGeert van LooWim DeclercqP SCHOTTEI VAN DEN BRANDES MANDRUZZATOP VAN DER BRUGGENWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.

LC PENNINGRG SCHIPPERDominique VercammenAAJ VERHOFSTADT DENECKERRudi BeyaertPeter Vandenabeele

A1 Journal Article in CYTOKINE

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenK VANCOMPERNOLLEPeter VandenabeeleGuy HaegemanWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II

JB PRINSEC LEDGERWOODPaul AmelootPeter VandenabeelePR FARACONA BRIGHTS O'RAHILLYJR BRADLEY

A1 Journal Article in BIOSCIENCE REPORTS

Use of the yeast three-hybrid system as a tool to study caspases.

Wim Van CriekingeMaria (Marjan) van GurpEls DecosterPeter SchotteMarc Van De CraenWalter FiersPeter VandenabeeleRudi Beyaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

1997

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.

Dirk De ValckKaren HeyninckWim Van CriekingePeter VandenabeeleWalter FiersRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bactericidal permeability-increasing protein release in whole blood ex vivo: Strong induction by lipopolysaccharide and tumor necrosis factor-alpha.

MA DENTENERGJM FRANCOTPS HIEMSTRAATJ TOOLAJ VERHOEVENPeter VandenabeeleWA BUURMAN

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Cell death induction by receptors of the TNF family: Towards a molecular understanding.

D WALLACHM BOLDINE VARFOLOMEEVRudi BeyaertPeter VandenabeeleWalter Fiers

A1 Journal Article in FEBS LETTERS

Characterization of seven murine caspase family members

Marc Van de CraenPeter VandenabeeleWim DeclercqIlse Van den BrandeGeert van LooFrancis MolemansPeter SchotteWim Van CriekingeRudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

Cleavage of caspase family members by granzyme B: A comparative study in vitro.

M VANDECRAENI VANDENBRANDEWim DeclercqM IRMLERRudi BeyaertJ TSCHOPPWalter FiersPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.

Rudi BeyaertVJ KIDDSigrid CornelisM VANDECRAENGeertrui DeneckerJM LAHTIR GURURAJANPeter VandenabeeleWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.

RMY BARGER WILLEMZEPeter VandenabeeleWalter FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1.

F LARDONHW SNOECKZN BERNERMANFI VANTENDELOOG NIJSM LENJOUE HENCKAERTSCJ BOECKXTAENSPeter VandenabeeleLL KESTENS et al.

A1 Journal Article in IMMUNOLOGY

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

Dominique VercammenPeter VandenabeeleRudi BeyaertWim DeclercqWalter Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

Functional characterization of the prodomain of interleukin-1 beta-converting enzyme.

Wim Van CriekingeRudi BeyaertM VANDECRAENPeter VandenabeelePeter SchotteD DEVALCKWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia.

A MARCHANTZ AMRAOUIC GUEYDANC BRUYNSO LEMOINEPeter VandenabeeleWalter FiersWA BUURMANM GOLDMAN

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.

F BENIGNIR FAGGIONIM SIRONIG FANTUZZIPeter VandenabeeleNozomi TakahashiS SACCOWalter FiersWA BUURMANP GHEZZI

A1 Journal Article in JOURNAL OF IMMUNOLOGY

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

1995

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A1 Journal Article in TRENDS IN CELL BIOLOGY

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A2 Journal Article in J. Immunol.. 154, pp. 2904-2913

BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.

Rudi BeyaertBart VanhaesebroeckWim DeclercqJ VANLINTPeter VandenabeeleP AGOSTINISJR VANDENHEEDEWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.

D VERCAMMENPeter VandenabeeleWim DeclercqM VANDECRAENJohan GrootenWalter Fiers

A1 Journal Article in CYTOKINE

Dimerization of chimeric erythropoietin 75 kDa tumour-necrosis-factor (TNF) receptors transduces TNF signals - Necessity for the 75 kDa TNF-receptor transmembrane domain.

Wim DeclercqPeter VandenabeeleWalter Fiers

A1 Journal Article in CYTOKINE

Generation and biological characterization of membrane-bound, uncleavable murine tumor-necrosis factor.

Els DecosterBart VanhaesebroeckPeter VandenabeeleJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Two tumour necrosis factor receptors : structure and function

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A2 Journal Article in TRENDS IN CELL BIOLOGY

1994

DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS.

JAJ BARBARAWB SMITHJR GAMBLEXaveer VANOSTADEPeter VandenabeeleJan TavernierWalter FiersMA VADASAF LOPEZ

A1 Journal Article in EMBO JOURNAL

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleV GOOSSENSRudi BeyaertWim DeclercqJohan GrootenB VANHAESEBROECKM VANDECRAEND VERCAMMENB DEPUYDTG DENECKER et al.

A1 Journal Article in CIRCULATORY SHOCK

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.

Xaveer Van OstadePeter VandenabeeleJan TavernierWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

IFN-GAMMA PREVENTS TH2 CELL-MEDIATED PATHOLOGY AFTER NEONATAL INJECTION OF SEMIALLOGENIC SPLEEN-CELLS IN MICE.

V DONCKIERD ABRAMOWICZC BRUYNSS FLORQUINML VANDERHAEGHENZ AMRAOUIC DUBOISPeter VandenabeeleM GOLDMAN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

In vivo immunosuppression induced by a weakly mitogenic antibody to mouse CD3: evidence that induction of long-lasting in vivo unresponsiveness requires TcR signaling

Véronique FlamandVincent DonckierDaniel AbramowiczMichel GoldmanPeter VandenabeeleJacques UrbainMuriel MoserOberdan Leo

A1 Journal Article in CELLULAR IMMUNOLOGY

INTERLEUKIN-10 CONTROLS INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR PRODUCTION DURING EXPERIMENTAL ENDOTOXEMIA.

A MARCHANTC BRUYNSPeter VandenabeeleM DUCARMEC GERARDA DELVAUXD DEGROOTED ABRAMOWICZT VELUM GOLDMAN

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal-antibody in mice by interleukin-10.

V DONCKIERV FLAMENTC GERARDD ABRAMOWICZPeter VandenabeeleM WISSINGA DELVAUXWalter FiersO LEOT VELU et al.

A1 Journal Article in TRANSPLANTATION

The protective role of interleukin-10 in endotoxin shock

A MARCHANTC BRUYNSPeter VandenabeeleD ABRAMOWICZC GÉRARDA DELVAUXP GHEZZIT VELUM GOLDMAN

A2 Journal Article in Progress in clinical and biological research

1993

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR.

Xaveer Van OstadePeter VandenabeeleBart EveraerdtH LOETSCHERR GENTZM BROCKHAUSW LESSLAUERJan TavernierPeter BrouckaertWalter Fiers

A1 Journal Article in NATURE

INCREASED IL-6 PRODUCTION AND IL-6-MEDIATED IG SECRETION IN MURINE HOST-VS-GRAFT DISEASE.

Peter VandenabeeleD ABRAMOWICZD BERUSJ VANDERHEYDENJohan GrootenV DONCKIEREL HOOGHEPETERSM GOLDMANWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTERLEUKIN-10 REDUCES THE RELEASE OF TUMOR-NECROSIS-FACTOR AND PREVENTS LETHALITY IN EXPERIMENTAL ENDOTOXEMIA.

C GERARDC BRUYNSA MARCHANTD ABRAMOWICZPeter VandenabeeleA DELVAUXWalter FiersM GOLDMANT VELU

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

Peter VandenabeeleWim DeclercqDominique VercammenMarc Van De CraenJohan GrootenHansruedi LoetscherManfred BrockhausWerner LesslauerWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1991

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone

Maria-Luisa AlegrePeter VandenabeeleMichel DepierreuxSandrine FlorquinMonique Deschodt-LanckmanVeronique FlamandMuriel MoserOberdan LeoJacques UrubainWalter Fiers et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enzymatic degradation of tumor necrosis factor by activated human neutrophils: role of elastase

Joëlle NortierPeter VandenabeeleEtienne NoêlYves BosseloirMichel GoldmanMonique Deschodt-Lanckman

A1 Journal Article in LIFE SCIENCES

Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome

Maria-Luisa AlegreKarine GastadelloDaniel AbramowiczPaul KinnaertPierre VereerstraetenLuc De PauwPeter VandenabeeleMuriel MoserOberdan LeoMichel Goldman

A1 Journal Article in TRANSPLANTATION

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

Peter VandenabeeleWalter Fiers

Editorial material

1990

Acute toxicity of anti-CD3 monoclonal antibody in mice : a model for OKT3 first dose reactions

M AlegreM DepierreuxS FlorquinT NajdovskiPeter VandenabeeleD AbramowiczO LeoM Deschodt-LanckmanM Goldman

A1 Journal Article in TRANSPLANTATION PROCEEDINGS

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1

Peter VandenabeeleWim DeclercqClaude LibertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Hypothermia and hypoglycemia induced by anti-CD3 monoclonal antibody in mice : role of tumor necrosis factor

Marisa AlegrePeter VandenabeeleVéronique FlamandMuriel MoserOberdan LeoDaniel AbramowiczJacques UrbainWalter FiersMichel Goldman

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression

Peter VandenabeeleJohan GrootenWalter Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis

Michel GoldmanPeter VandenabeeleJean MoulartZoulika AmraouiDaniel AbramowiczJoëlle NortierJean-Louis VanherweghemWalter Fiers

A1 Journal Article in NEPHRON

Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice

Daniel AbramowiczPhilippe VandervorstCatherine BruynsJean-Marc DoutrelepontPeter VandenabeeleMichel Goldman

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Response of murine cell lines to an IL-1/IL-2 induced factor in a rat mouse T hybridoma (PC60) : differential induction of cytokines by human IL-1α and IL-1β and partial amino acid sequence of rat GM-CSF

Peter VandenabeeleYves GuisezWim DeclercqGuy BauwJoël VandekerckhoveWalter Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

1988

Interleukin 1α acts as an autocrine growth factor for RPMI1788, an Epstein-Barr virus-transformed human B cell line

Peter VandenabeeleBettadapura JayaramRené DevosAlan ShawWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Plasmacytoma growth factor activity of murine granulocyte-macrophage colony-stimulating factor

Anne VinkPeter VandenabeeleCatherine UyttenhoveSylvie CayphasJacques Van Snick

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1987

A T cell clone which responds to interkeukin 2 but not to interleukin 4

Werner MüllerPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-β2, HPGF)

P PoupartPeter VandenabeeleS CayphasJ Van SnickGuy HaegemanV KruysWalter FiersJ Content

A1 Journal Article in EMBO JOURNAL

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

1985

Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus cowan strain I activated human B-cells

René DevosBettadapura JayaramPeter VandenabeeleWalter Fiers

A1 Journal Article in IMMUNOLOGY LETTERS