Dysfunction of enteroendocrine cells in constipation

Taking IBD Genes from GWAS to Function to Drug Target

Doctoral project Aigerim Aidarova

Doctoral project Alice Borghi

Doctoral project Annelies Demeyer

Doctoral project Anne-Marie Pauwels

Doctoral project Christina Müller

Doctoral project Domien Vanneste

Doctoral project Elien Van Nuffel

Doctoral project Ellen Audenaert

Doctoral project Elodie Kip

Doctoral project Laura Meloni

Doctoral project Lynn Elton

Doctoral project Marie Lork

Doctoral project Thomas Volckaert

Functional characterization of novel IBD candidate genes in intestinal epithelial cells

Functional characterization of novel IBD candidate genes in T cells

Gut epithelium signalling in intestinal motility

Identification and functional characterization of CARD14 protein-protein interactions

Role and mechanism of action of the E2 conjugating enzyme UBE2L3 in immunity and inflammation.

Role of MALT1 substrate cleavage in immune regulation: insights from a mouse gene targeting approach

Targeting and regulation of interleukin-33 signalling in lung inflammation

Unraveling the functional roles of endogenous phytohormones in mammals

Doctoral project Leen Catrysse

The Effect of Hypoxia and Hypoxia Inducible Factors on the Glucocorticoid Receptor Function and their Role during Sepsis

The role of enteroendrocrine cells in the gut in inflammatory bowel disease.

Amplification of the expression of negative feedback control proteins as a novel anti-inflammatory mechanism of glucocorticoids

A novel player in intestinal inflammation and motility

A novel role for CARD14 in prostate cancer

BCCM "Biological Resource Centre (BRC) - LMBP - C4 / 02/029 - Budget 2014

BCCM/GeneCorner- budget year 2018-2021

BCCM/LMBP budget year 2015

BCCM / LMBP - Budget Year 2016

Biological Resource Centre (BRC) BCCM/LMBP

Biosynthesis and physiological role of endogenous mammalian “phytohormones” in health and disease

CARD14/MALT1 signaling in keratinocytes: from molecular characterisation to validation as therapeutic target

Characterisation of Pellino proteins as modulators in IL-1 and TLR signal transduction

Characterisation of ST2/IL-33 signaling and evaluation of the therapeutic potential of nanobody mediated targeting of IL-33

Characterisation of the biochemical and physiological function of CARMA2 in the context of psoriasis 

Characterisation of the biochemical and physiological function of CARMA2 in the context of psoriasis

Characterisation of the physiological function of CARD14 in the context of psoriasis

Characterisation of the physiological role of the NF-kB inhibitor A20 via genetic modification in mice

Characterization of CARD14 as a novel player in inflammatory bowel disease

Characterization of group I metabotropic glutamate receptor-induced NF-kappaB signaling in T cells

Characterization of pro-inflammatory signaling in keratinocytes

Characterization of the in vivo role of MALT1 protease activity in inflammation and immunity

Characterization of the in vivo role of MALT1 proteolytic activity in inflammation and immunity

Characterization of the physiological role of NF-kB inhibitor A20 by genetic modifications into the mouse

Characterization of the physiological role of the NF-kB and IFN regulatory proteins A20 and DUBA by genetic modification in the mouse.

Characterization of the role of MALT1 paracaspase in antiviral immunity

Chlorea toxin as a delivery system for peptide CTL epitopes

Crosstalk between the MALT1 and Caspase-8 Signaling Complexes in Immune Activation: N-Terminomics versus ubiquitinomics

Elucidating the details of the interaction between specific nutrients-microbiota-intestinal health and the consequences for inflammatory diseases

Engineering of an abscisic acid (ABA)-producing probiotic yeast strain to modulate host microbiota, intestinal health and inflammatory diseases

European Consortium of Microbial Resources Centres - EMbaRC

From bed to bench: Insights from novel pathogenic RC3H1 and ZC3H12A variants in patients with autoimmune disease and immune dysregulation syndromes.

Functional characterization of MALT1 and CARD14 in psoriasis

GeneCorner- BCCM "Biological Resource Centre (BRC) - budget 2022-2024

Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C).

Healthcare applications of targeted protein aggregation

Moleculair and functional characterization of MALT1-proteolytic activity in NF-B activation and lymphoma development

Molecular and cellular mechanisms in inflammation and immunity

Molecular and functional characterization of MALT1-proteolytic activity in NF-kB activation and lymphoma development

Molecular and functional characterization of the tumor suppressors CYLD and A20 as ubiquitin modulating enzymes

Molecular mechanisms involved in the regulation of the paracaspase MALT1 in T cel receptor induced signal transduction

Molecular mechanisms regulating the activity and specificity of CYLD in T cells

Negative regulation of NF-kB in the pathophysiology of rheumatoid arthritis and systemic lupus erythermatosus

Novel anti-inflammatory mechanisms of glucocorticoids – towards a higher safety and efficacy

Novel macrophage and myeloid dendritic cell markers for in vivo imaging and therapy of inflammatory diseases; Inflammation tracking "Inflammatrack"

Respiratory Syncitial Virus immunology and molecular virology

RNAI collection and associated facilities

Role and regulation of the anti-inflammatory protein A20 in selective autophagy

Role of linear ubiquitination in intestinal inflammation and disease

Role of MALT1 in neuronal cells.

Role of MALT1 proteolytic activity in prostate cancer.

STRETCH: mechanotransduction in osteoimmunology: an innovative approach towards effective drug for rheumatic diseases

Structure-function analysis of the human paracaspase MALT1 in antigen receptor induced signal transduction to NF-kB dependent gene expression

Study of phagosomes of inflammatory dendritic cells as an intracellular platform to shape immune responses

Study of the molecular mechanisms regulating the activity and expression of the de-ubiquitinase protein DUBA in innate immune signaling.

Study of the molecular mechanisms that regulate the activity and the expression of the protein-ubiquitinerend DUBA in innate immune signaling.

Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse

The impact of MALT1 and MALT1-mediated CYLD cleavage on the development of IBD

The in vivo study of signaling pathways involved in cell survival and cell death within the central nervous system

The role of the C3H1 zinc finger protein Roquin1 in inflammation, from a genetic survey in hyperinflammatory disorders to therapeutic applicability.

Toll-like receptor 3 (TLR3) stimulation in the treatment of cancer

Valorisation of cytokine traps: IL33 as lead case

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

POXylation as next generation PEGylation

Purchase steam autoclave central kitchen Department of Biomedical Molecular Biology

Study of the impact of CYLD cleavage on lymphocyte function in vivo and its potential contribution to inflammatory and autoimmune disorders

Study of the (patho)physiological role of NF-kB inhibitors A20 and ABINs through genetic

Study of the role of the NF-kB-inhibitory protein A20 in inflammation-associated cancer

T cell receptor signaling pathways in autoimmune disease: the in vivo role of CYLD cleavage

The BD FACS Symphony FACS cell sorter: the most advanced multiparameter fluorescence activated cell sorter that allows the identification and purification of rare cells for further functional characterization