Research Explorer

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Project

Characterization of the physiological role of the NF-kB and IFN regulatory proteins A20 and DUBA by genetic modification in the mouse.

Outputs and Outcomes

Code

31505210

Duration

01 January 2010 → 31 December 2012

Funding

Research Foundation - Flanders (FWO)

Promotor

Rudi Beyaert

Research disciplines

Medical and health sciences
- Immunology
- Immunology
- Immunology

Keywords

inflammation NF-kappaB signal transduction

Project description

A20 and DUBA are two proteins that negatively regulate immune responses, but the physiological role of these proteins in specific tissues or cell types is largely unknown. In this project we aim to study the function of A20 and DUBA via the generation and characterization of cell type specific conditional knockout mice.

English

Dutch

English

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