Code
3E014508
Duration
01 October 2008 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
-
Medical and health sciences
- Immunology
- Medical biochemistry and metabolism
- Immunology
- Medical biochemistry and metabolism
- Immunology
- Medical biochemistry and metabolism
Keywords
proteolytic activity
NF-kB
signal transduction
Project description
The paracaspase MALT1 plays an important role in activation of NF-kB through T- and B-cell receptors. The aims of this project are: 1) To identifty new substrates for MALT1 and to characterize their role. 2) To identify the molecular mechanisms that regulate MALT1 proteolytic activity.