Characterisation of Pellino proteins as modulators in IL-1 and TLR signal transduction

01 January 2007 → 31 December 2009
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Evolutionary biology
    • General biology
  • Medical and health sciences
    • Immunology
    • Immunology
    • Social medical sciences
    • Immunology
signaling infection immunity
Project description

IL-1 and TLRs play an important role in the innate immune respons against infection. In this research proejct, we wish to study the role of the recently identified Pellino proteins in IL-1 and TLR induced signalling to NF-kB adn MAPK activation, more specifically at the level of protein ubiquitination and protein-protein interactions with Pellino.